The Sydney System: Histological division

Price, Ashley B.

doi:10.1111/j.1440-1746.1991.tb01468.x

Cited by 945 publications

(502 citation statements)

References 38 publications

(3 reference statements)

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“…It may be a good model of inflammation-associated carcinogenesis, because H. pylori infection induces intense acute and chronic inflammatory reaction that may last for decades (Price, 1991;Dixon et al, 1996). Moreover, H.pylori infection, environmental exposures, host genetic susceptibility, or some combination of these factors can lead to increased expression of cytokines, growth factors and their receptors, which in turn promotes cellular proliferation (Coussens and Werb, 2002;Lu et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Yang¹,

Zhang²,

Chen³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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We conducted a case-control study to determine the association between several potential SNPs of excision repair cross complementing group 5 (XPG) and gastric cancer susceptibility, and roles of XPG polymorphisms in combination with H.pylori infection in determining risk of gastric cancer. In our study, we collected 337 newly diagnosed gastric cancer cases and 347 health controls. Three SNPs of XPG, rs2296147T>C, rs2094258C>T and rs873601G>A, were genotyped using the Taqman real-time PCR method with a 7900 HT sequence detector system. H. pylori infection was diagnosed by ELISA. By multivariate logistic regression analysis, the rs2296147 CC genotype was associated with a decreased risk of gastric cancer (OR=0.52, 95% CI=0.27-0.97), and rs2094258 TT was associated with elevated risk (OR=2.13, 95% CI=1.22-3.35). Positive H.pylori individuals with rs2094258 TT genotypes demonstrated increased risk of gastric cancer (OR=2.13, 95% CI=1.22-3.35), while rs2296147 CC was associated with lower risk among patients with negative H.pylori (OR=0.45, 95%CI=0.22-0.89). Our findings suggested that XPG polymorphisms might contribute to risk of gastric cancer among Chinese populations, but the effect needs to be further validated by larger sample size studies.

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Section: Discussionmentioning

confidence: 99%

SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Yang¹,

Zhang²,

Chen³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…All mucosal specimens were stained with haematoxylin and eosin to grade the gastritis and with the Warthin-Starry stain to grade the mucosal colonization by H. pylori, in accordance with the Sydney System (Price 1991), but slightly modified as described elsewhere (Bayerdorffer et al, 1992;Stolte et al, 1995) using a semiquantitative scale (grade 0-4). Intestinal metaplasia (IM) and lymphoid follicles (LFs) were judged as present or absent.…”

Section: Methodsmentioning

confidence: 99%

Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori

Miehlke

Hackelsberger²,

Meining³

et al. 1998

Br J Cancer

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Summary In 50 Helicobacterpylori-infected gastric carcinoma patients the corpus gastritis was significantly higher than in matched H. pyloripositive control subjects (P < 0.01). Atrophy and intestinal metaplasia (IM) occurred significantly more often in the antrum of carcinoma patients (P < 0.01). The odds ratio for gastric carcinoma was 8.85 for high-grade corpus gastritis and 8.04 when atrophy in the antrum was present.

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“…Until the Sydney criteria were published, gastritis was defined loosely by the practicing pathologist without any standardization. In 1991, a group of pathologists gathered and produced an important document described as "the Sydney criteria" [7]. A few years later (1994) the document was revised and the histological standard for "gastritis" was established [8].…”

Section: Definition Of Gastritismentioning

confidence: 99%

Helicobacter-pylori Negative Gastritis in Children—A New Clinical Enigma

Elitsur

Preston

2014

Diseases

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Abstract:The decrease in the prevalence of Helicobacter pylori (Hp) infection in children in the world gave rise to a new pathological finding termed as Hp-negative gastritis. Unfortunately, the term "Hp-negative gastritis" has not been identified as a pathological process and has the status of a "second cousin"; in most publications it was never mentioned as a subject to be dealt with, but was "left over" data that was never the topic of the manuscripts' discussions. Only recently has the topic captured the attention of the pathologists who described this phenomenon in adults, yet the pathological and/or clinical spectrum or significance of this phenomenon has not been adequately investigated. In the current manuscript we describe Hp-negative gastritis in children, summarize its clinical prevalence and touch upon the possible etiology, pathology, and/or therapeutic implication. Overall, this review has concluded that Hp-negative gastritis is a pathological phenomenon in children that needs further investigation, and to date, as the title suggests, is a new clinical enigma that needs to be considered.

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The Sydney System: Histological division

Cited by 945 publications

References 38 publications

SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori

Helicobacter-pylori Negative Gastritis in Children—A New Clinical Enigma

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