Chronic gastric ulcer and life events

Thomas, J; Greig, Margaret; Piper, D. W.

doi:10.1016/0016-5085(80)90770-2

Cited by 49 publications

(8 citation statements)

References 16 publications

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“…A second study compared life stress (measured by the occurrence of 62 selected life events) in 147 patients 2 years prior to the diagnosis of gastric ulcer and in 73 patients 2 years following the diagnosis of gastric ulcer. No significant difference was observed [77]. These same authors did, however, comment in a subsequent review that, although ulcer patients and control subjects do not differ with respect to acute life stress, chronic difficulties (events or circumstances persisting z 6 months) were twice as common in duodenal ulcer patients as in control subjects [5].…”

Section: Psychophysiological Mechanisms For Stress and Ulcer Diseasementioning

confidence: 87%

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The role of psychosocial factors in peptic ulcer disease: Beyond Helicobacter pylori and NSAIDs

Jones

2006

Journal of Psychosomatic Research

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Section: Psychophysiological Mechanisms For Stress and Ulcer Diseasementioning

confidence: 87%

“…Studies by Thomas et al [77] and Piper et al [78], however, have not supported the relationship between life stress and the diagnosis of gastric ulcer. Patients with gastric ulcer and control subjects were not found to differ with respect to 31 major life events [78].…”

Section: Psychophysiological Mechanisms For Stress and Ulcer Diseasementioning

confidence: 95%

The role of psychosocial factors in peptic ulcer disease: Beyond Helicobacter pylori and NSAIDs

Jones

2006

Journal of Psychosomatic Research

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“…Stress-induced ulcer better resembles clinical ulcers in chronicity, severity and practicality of experiencing stress due to varietal patterns of lifestyle in day to day life and serves the most reliable model to study ulcer healing process (Thomas et al, 1980;Jones, 2006). The incidence of swim stress-induced ulcer is predominant in the glandular part of the stomach leading to gastric mucosal/mucin damage.…”

Section: Discussionmentioning

confidence: 98%

Gastroprotective effect of swallow root (Decalepis hamiltonii) extract: Possible involvement of H+–K+–ATPase inhibition and antioxidative mechanism

Naik

Jayaram

Nayak

et al. 2007

Journal of Ethnopharmacology

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“…It is noted that using the same instrument, results similar to this study have been found in both duodenal22 and gastric ulcer patients. 23 In conclusion, this study suggests that life stress events are no more frequent or significantly different in type in a population with dyspepsia of unknown cause than in a community control population. The measures applied cannot assess a particular individual's reaction to events and do not assess chronic stress, and for these reasons emotional stress may still play some role in the aetiology of the disorder.…”

Section: Discussionmentioning

confidence: 56%

“…To make the results comparable with similar studies on duodenal ulcer and gastric ulcer patients,22 23 this study was analysed in a similar way. As there were no significant differences in any of the comparisons between patients interviewed within one month or a mean of 3-6 months after diagnosis, using stepwise regression analysis, these two groups were combined and the results presented apply to all patients.…”

Section: Resultsmentioning

confidence: 99%

Major life event stress and dyspepsia of unknown cause: a case control study.

Talley¹,

Piper²

1986

Gut

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SUMMARY Stress is purported to be a major cause of non-ulcer dyspepsia, defined here as dyspepsia where peptic ulcer, oesophagitis, and cancer are excluded by endoscopy. There is a subgroup of non-ulcer dyspepsia patients who have no definite cause for their dyspepsia, provisionally termed essential dyspepsia. The aim of the present study was to determine if stress, as measured by major life events, was associated with essential dyspepsia. The frequency of life events during the year before the diagnosis of essential dyspepsia in 68 consecutive patients was compared with the frequency of these events over the same time period in 68 randomly selected age and sex-matched community controls. The mean number of events and the associated life change and distress scores were similar for both groups. Concerning individual events, patients reported more minor personal illness (p=0008). When events were broadly categorised, only one difference was found -more controls reported bereavements (p=0008). Age, sex, social class, and the duration of dyspepsia did not influence the number and nature of events. Although the study suggests that stress, as measured by major life events, is not associated with dyspepsia of unknown cause, it does not exclude the fact that other forms of stress, especially that associated with chronic difficulties, may be relevant.Non-ulcer dyspepsia, also called radio rapically negative dyspepsia or nervous dyspepsia,'-is one of the commonest conditions seen by gastroenterologists and general practitioners. It is a commonly held belief that this disorder occurs when the patient is exposed to psychological stress2-but there has been no formal study of stress and non-ulcer dyspepsia. Stress may be defined as a response to a situation or stimulus -for example, death of a spouse, birth of a child -and, in the context of this study, the stimuli are major life events. Holmes and Rahe,7 Paykel and associates8 and Tennant and Andrews9 have defined a number of such stressful events, and the distress and change in life patterns that each event may cause have been quantified.The aim of the present study was to determine whether a subgroup of non-ulcer dyspepsia patients who have no definable cause for their dyspepsia, provisionally termed essential dyspepsia, experience an excess of life events during the one year preceding diagnosis, when compared with a community control population.

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Chronic gastric ulcer and life events

Cited by 49 publications

References 16 publications

The role of psychosocial factors in peptic ulcer disease: Beyond Helicobacter pylori and NSAIDs

The role of psychosocial factors in peptic ulcer disease: Beyond Helicobacter pylori and NSAIDs

Gastroprotective effect of swallow root (Decalepis hamiltonii) extract: Possible involvement of H+–K+–ATPase inhibition and antioxidative mechanism

Major life event stress and dyspepsia of unknown cause: a case control study.

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