The role of psychosocial factors in peptic ulcer disease: Beyond Helicobacter pylori and NSAIDs

Occurrence of gastric ulcers in horses exercised on a treadmill

“…However, nonspecific clinical signs, such as apathy or decreased performance, are quite frequent, while many animals with gastric ulceration may not display obvious signs (JONES, 2006). In the present study, the horses displayed no obvious change suggesting the occurrence of gastric lesions.…”

Selye’s general adaptation syndrome: stress-induced gastro-duodenal ulceration and inflammatory bowel disease

“…The case for the importance of psychosocial stress factors in the causation of peptic ulcer disease has been summarized as follows (Levenstein 2000, Jones 2006, Realo et al 2015. First, despite the decreasing prevalence of H. pylori infection in Western societies, the burden of peptic ulcer disease remains high.…”

Hypnosis in Cancer Patients: Can We Do Better?

“…Thanks to Gershon's findings (1965Gershon's findings ( , 1998 on the importance of what he called "the second brain", we now know that one of the most influential hormones on mood and depression (serotonin) is mainly secreted by enteric neurons, and that these neurons together form a network capable of autonomous responses. The digestive system is known to respond to psychological stress and emotions (Jones, 2006) although gastric troubles as ulcers have recently disappeared from the list of the psychosomatic diseases 5 . In 2008, Charioni et al reviewed the literature testing the efficacy of hypnosis in the modulation of upper digestive motor and secretory function (more than 20 published reports).…”