Chronic Endometritis: Potential Cause of Infertility and Obstetric and Neonatal Complications

Kitaya, Kotaro; Matsubayashi, Hidehiko; Yamaguchi, Kensei; Nishiyama, R.; Takaya, Y.; Ishikawa, Tomomoto; Yasuo, Tadahiro; Yamada, Hisao

doi:10.1111/aji.12438

Cited by 174 publications

(164 citation statements)

References 46 publications

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“…Hydrosalpinx, or a blocked fallopian tube is also associated with implantation failure (44), with improvement noted after salpingectomy (45–48). Endometritis, an inflammation of the endometrium, is also associated with infertility and obstetrical complications (49). Endometritis is associated with aberrant inflammatory cytokine expression and has been associated with endometriosis (50).…”

Section: Impaired Expression Of Endometrial Factors Correlates With Rmentioning

confidence: 99%

Local and systemic factors and implantation: what is the evidence?

Fox

Morin

Jeong

et al. 2016

Fertility and Sterility

139

124

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Significant progress has been made in the understanding of embryonic competence and endometrial receptivity since the inception of Assisted Reproductive Technologies (ART). The endometrium is a highly dynamic tissue that plays a crucial role in the establishment and maintenance of normal pregnancy. In response to steroid sex hormones, the endometrium undergoes marked changes during the menstrual cycle that are critical for acceptance of the nascent embryo. There is also a wide body of literature on systemic factors that impact ART outcomes. Patient prognosis is impacted by an array of factors that tip the scales in her favor or against success. Recognizing the local and systemic factors will allow clinicians to better understand and optimize the maternal environment at the time of implantation. This review will address the current literature on endometrial and systemic factors related to impaired implantation and highlight recent advances in this area of reproductive medicine.

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Section: Impaired Expression Of Endometrial Factors Correlates With Rmentioning

confidence: 99%

Local and systemic factors and implantation: what is the evidence?

Fox

Morin

Jeong

et al. 2016

Fertility and Sterility

139

124

View full text Add to dashboard Cite

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“…Gynecologists and pathologists often do not focus much clinical attention on CE due to the time-consuming microscopic examinations necessary to diagnose CE, its mild clinical manifestations, and the benign nature of the disease [45]. However, the possible relationship of CE with infertility and/or perinatal complications has recently emerged as an area of ongoing research [6]. …”

Section: Introductionmentioning

confidence: 99%

Chronic endometritis and infertility

Park

Kim

Yoon

et al. 2016

Clin Exp Reprod Med

134

111

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Chronic endometritis (CE) is a condition involving the breakdown of the peaceful co-existence between microorganisms and the host immune system in the endometrium. A majority of CE cases produce no noticeable signs or mild symptoms, and the prevalence rate of CE has been found to be approximately 10%. Gynecologists and pathologists often do not focus much clinical attention on CE due to the time-consuming microscopic examinations necessary to diagnose CE, its mild clinical manifestations, and the benign nature of the disease. However, the relationship between CE and infertility-related conditions such as repeated implantation failure and recurrent miscarriage has recently emerged as an area of inquiry. In this study, we reviewed the literature on the pathophysiology of CE and how it may be associated with infertility, as well as the literature regarding the diagnosis and treatment of CE. In addition, we discuss the value of hysteroscopic procedures in the diagnosis and treatment of CE.

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“…7 Disorders in female fertility are often caused by chronic inflammatory processes within the uterus. 8 Hysteroscopy, a standard diagnostic tool based on macroscopic examination, reveals chronic endometritis in only 35% of cases 9 and should be complemented by an invasive endometrial biopsy. 10 In this respect, noninvasive diagnostic techniques for gynecology applications are required.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography in gynecology: a narrative review

2017

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Abstract. Modern gynecologic practice requires noninvasive diagnostics techniques capable of detecting morphological and functional alterations in tissues of female reproductive organs. Optical coherence tomography (OCT) is a promising tool for providing imaging of biotissues with high resolution at depths up to 2 mm. Design of the customized probes provides wide opportunities for OCT use in gynecology. This paper contains a retrospective insight into the history of OCT employment in gynecology, an overview of the existing gynecologic OCT probes, including those for combination with other diagnostic modalities, and state-of-the-art application of OCT for diagnostics of tumor and nontumor pathologies of female genitalia. Perspectives of OCT both in diagnostics and treatment planning and monitoring in gynecology are overviewed. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Chronic Endometritis: Potential Cause of Infertility and Obstetric and Neonatal Complications

Cited by 174 publications

References 46 publications

Local and systemic factors and implantation: what is the evidence?

Local and systemic factors and implantation: what is the evidence?

Chronic endometritis and infertility

Optical coherence tomography in gynecology: a narrative review

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