Chronic Cadmium Hepatooxidative in Rats: Treatment with Haruan Fish (Channa striata) Extract

Suhartono, Eko; Triawanti,; Yunanto, Ari; Firdaus, Rizky Taufan; Iskandar, Iskandar

doi:10.1016/j.apcbee.2013.05.076

Cited by 35 publications

(33 citation statements)

References 17 publications

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“…5, No. 3, June 2014 kidney, brain and testes where MDA is used as an indicator of oxidative damage [7], [10], [17].…”

Section: International Journal Of Chemical Engineering and Applicatiomentioning

confidence: 99%

“…MDA was measured by the method of Buege and Aust [7]. The colour was measured spectrophotometrically at 532 nm.…”

Section: ) Determination Of Malondyaldehidementioning

confidence: 99%

“…Determination of H 2 O 2 concentration by the modified FOX2 method [7]. Solutions measured spectrophotometrically at  = 505 nm.…”

Section: ) Determination H 2 O 2 Concentrationmentioning

confidence: 99%

“…Cd has been associated with occurence of increased oxidative stress and cancer [10]. Cd generates ROS which depletes endogenous ROS scavengers and long term exposure to Cd increased lipid peroxidation and caused inhibition of SOD activity indicating oxidative damage in liver [7]. Animal studies have shown that Cd can stimulate formation of reactive oxygen species (ROS) and induce damage to various tissues [10].…”

Section: Introductionmentioning

confidence: 99%

“…Chronic intake of Cd in contaminated food or air produces organ dysfunction as a result of cell death, resulting in pulmonary, hepatic and renal tubular diseases [7].…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress of Cadmium-Induced Ovarian Rat Toxicity

Tribowo¹,

Arizal²,

Nashrullah³

et al. 2014

IJCEA

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Abstract-Cadmium (Cd), a common toxic heavy metal, is widely distributed in the environment due to its use in industry. In the industry, Cd is hazardous both by inhalation and ingestion and can cause acute and chronic toxicity. Exposure to Cd had been known to cause damage to organs such as kidney, liver and testis. In this present study Cd was proposed caused an oxidative stress in ovarian rat (Rattus novergicus) cells. Female Rattus novergicus was divided in two groups, one control groups and one case group were exposed by Cd. Furthermore we set Superoxidismutase (SOD), Peroxidase (POX) and catalase (CAT) activity with Hydrogen peroxide (H 2 O 2 ) and Malondyaldehide (MDA) as a biomarker of oxidative stress. For analyzing of the data, SPSS software version 17 was used and was examined by Mean-Whitney test. For all outcomes, a nominal p-value of p<0.05 was considered significant. The resulted showed that there are a significance differences SOD, GPx and catalase activity between case and control group. The resulted also showed a significance differences H 2 O 2 and MDA levels between case and control group. The result suggest that Cd induced oxidative stress in ovarian cells.Index Terms-Antioxidant enzym, cadmium, ovarian cells and oxidative stress.

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“…5, No. 3, June 2014 kidney, brain and testes where MDA is used as an indicator of oxidative damage [7], [10], [17].…”

Section: International Journal Of Chemical Engineering and Applicatiomentioning

confidence: 99%

“…MDA was measured by the method of Buege and Aust [7]. The colour was measured spectrophotometrically at 532 nm.…”

Section: ) Determination Of Malondyaldehidementioning

confidence: 99%

“…Determination of H 2 O 2 concentration by the modified FOX2 method [7]. Solutions measured spectrophotometrically at  = 505 nm.…”

Section: ) Determination H 2 O 2 Concentrationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Chronic intake of Cd in contaminated food or air produces organ dysfunction as a result of cell death, resulting in pulmonary, hepatic and renal tubular diseases [7].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Oxidative Stress of Cadmium-Induced Ovarian Rat Toxicity

Tribowo¹,

Arizal²,

Nashrullah³

et al. 2014

IJCEA

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Environmental exposure to cadmium—a risk for health of the general population in industrialized countries and preventive strategies

Mężyńska

Brzóska

2017

Environ Sci Pollut Res

235

129

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Cadmium (Cd) is a heavy metal belonging to the group of the main chemical pollutants of the natural and occupational environment in economically developed countries. The forecasts indicate that contamination of the environment with this toxic metal, and thus the exposure of the general population, will increase. Food (particularly plant products) is the main source of the general population exposure to this element. Moreover, an important, and often the main, source of intoxication with Cd is habitual tobacco smoking. Recent epidemiological studies have provided numerous evidence that even low-level environmental exposure to this toxic metal, nowadays occurring in numerous economically developed countries, creates a risk for health of the general population. The low-level lifetime exposure to this metal may lead to the damage to the kidneys, liver, skeletal system, and cardiovascular system, as well as to the deterioration of the sight and hearing. Moreover, it has been suggested that environmental exposure to this xenobiotic may contribute to the development of cancer of the lung, breast, prostate, pancreas, urinary bladder, and nasopharynx. Taking the above into account, the aim of this review article is to draw more attention to Cd as an environmental risk factor for the health of the general population and the need to undertake preventive actions allowing to reduce the risk of health damage due to a lifetime exposure to this toxic metal.

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