Oxidative Stress of Cadmium-Induced Ovarian Rat Toxicity

Tribowo, Jefry Albari; Arizal, Muhammad Hendy; Nashrullah, M.; Aditama, A. R.; Utama, D. G.

doi:10.7763/ijcea.2014.v5.389

Cited by 6 publications

(9 citation statements)

References 17 publications

(28 reference statements)

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“…Thiols interact and can eventually neutralize hydroxyl radicals and nitric oxide metabolites. 43 Since cadmium induces the formation of free radicals and ROS, 44 it may also be involved in the reduction of serum thiol levels. Additionally, cadmium adverse effects on thiol production may be due to its high affinity for -SH groups.…”

Section: Discussionmentioning

confidence: 99%

Curcumin protects the testis against cadmium-induced histopathological damages and oxidative stress in mice

Momeni

Eskandari

2019

Hum Exp Toxicol

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Background: Cadmium is an environmental pollutant which can induce the overproduction of free radicals while suppressing the antioxidant defense system. Curcumin is considered a free-radical scavenger and a potent antioxidant. This study was conducted to investigate the effect of curcumin on serum antioxidant enzymes and histopathological changes in mice treated with cadmium. Methods: In this experimental study, adult mice were divided into four groups, namely, control, cadmium chloride (5 mg kg−1), curcumin (100 mg kg−1), and curcumin+cadmium chloride. The animals received curcumin 24 h prior to cadmium chloride injection. After 24 h, blood samples were collected and used to assess the levels of malondialdehyde (MDA), antioxidant enzymes activity (catalase, superoxide dismutase, and glutathione peroxidase), total glutathione, total thiol, and hydrogen peroxide. Histopathological evaluation was also performed for testicular tissue. Results: Mice treated with cadmium showed a significant ( p < 0.001) decrease in the activity of antioxidant enzymes, serum amounts of total glutathione and total thiol, and the diameter of seminiferous tubules compared to the control group. This pollutant also significantly ( p < 0.001) increased serum levels of MDA and hydrogen peroxide and the lumen diameter of seminiferous tubules compared to the control group. In the curcumin+cadmium group, curcumin significantly ( p < 0.001) reversed the adverse effects of cadmium, compared to the cadmium group. In addition, curcumin alone significantly ( p < 0.001) increased serum glutathione peroxidase activity and thiol content compared to the control group. Conclusion: Curcumin, as a potent antioxidant, could compensate the adverse effects of cadmium on lipid and protein peroxidation, potentiated serum antioxidant defense system, and ameliorated some morphometrical parameters in the testis of cadmium-treated mice.

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Section: Discussionmentioning

confidence: 99%

Curcumin protects the testis against cadmium-induced histopathological damages and oxidative stress in mice

Momeni

Eskandari

2019

Hum Exp Toxicol

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“…Fundamentally, shreds of evidence have demonstrated the connection of oxidative stress to the central nervous system i.e. pathology of neurological disorders [ 6 ] and the susceptibility of the somatic nervous system (cellular toxicity) to oxidative damage has been conventionally established [ 29 , 30 ]. Nonetheless, the mechanistic applications underlying the nervous system (neuronal toxicity) and cellular system (ovarian-toxicity) using the mammalian model during mixed exposure to environmental toxicants are largely unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Fertility disorders associated with abnormal neuronal signaling molecules are speculated to be prevalent among womenfolk in industrialized countries due to consequential exposure to mixed-environmental chemicals. In the past, cancer of the testes, ovaries, prostate, varicoceles, brain, and CNS tumor were identified as the major challenge in human subjects exposed to mixed-metals and toxicants from drinks, foods, and workplaces [ [4] , [5] , [6] ]. Also, childlessness and sterility connected to ovarian dysfunction had been identified in females with a high risk of the psychiatric disorder [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…The report also suggested that Italian women with menopause trigger metabolic changes in the brain which may promote Alzheimer's diseases [ 8 ]. This might be linked to unregulated exposure to chemical agents that have the potential to interact with the ovary and/or ovules as well as their receptors to initiate ovarian impairment [ 6 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Metabolic depletion of synaptosomal enzymes linked with neurotoxicity and ovarian dysfunction by phenolic antioxidants of Croton zambsicus leaves in rats exposed to chronic mixture of anthropogenic toxicant

et al. 2021

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A complex mixture of organic contaminants and metals is associated with neuron-fertility disorders and studies have demonstrated that phenolic antioxidants from herbal origin, possesses a strong protective potential. This study aimed to investigate the protection of phenolic croton zambesicus (C-ZAMB) leaves against neuro-ovarian damage in rats exposed to chronic mixture of anthropogenic toxicants (EOMABRSL). The animals were divided into five groups (n = 10): Group I was given 0.5 ml of distilled water only; Group II received 0.5 ml of EOMABRSL for 98 days; Group III received 0.5 ml of EOMABRSL for 70 days and withdrew for 28 days; Group IV received 0.5 ml of EOMABRSL for 70 days +400 mg/kg phenolic C-ZAMB for 28 days; Group V received 400 mg/kg C-ZAMB only for 28 days via oral route. Both non-withdrawal and withdrawal EOMABRSL-exposed animals exhibited neuro-ovarian impairment by up-regulating neuronal 5 1 eco-nucleotidase (5 1 ENT), acetylcholinesterase (AChE), butrylcholinesterase (BuChE), synaptosomal monoamine oxidase-A (MAO-A) with altered cerebral antioxidants. Similarly, exposure to EOMABRSL for 98 and 70 days caused ovarian injury by amplifying the activity of 5 1 ENT with corresponding decline of fertility index, lactate dehydrogenase (LDH) and Δ5 17β-hydroxyl steroid dehydrogenase (Δ517β-HSD). EOMABRSL intoxication also increased the neuro-ovarian MDA content with reduced numbers of neonates. Phenolic antioxidants from C-ZAMB leaves identified by High Pressure Liquid Chromatography (HPLC) ameliorated the chronic EOMABRSL intoxication. The treatment also prevented ovarian lesions by depleting MDA content and improved antioxidant status. Thus, confirming its neuro-ovarian protection.

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“…Therefore, increased MDA levels observed in blood, ovary and uterus of treated rats in our study indicated to the oxidative damage caused to these tissues due to treatment with the metal mixture. dismutase (SOD) catalyzes the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen, while catalase (CAT) catalyzes the breakdown of toxic hydrogen peroxide (H2O2) to water (H2O2) and oxygen (O2) 39 . Glutathione (GSH) acts as a natural antioxidant and potential reducing agent.…”

Section: Cycle)mentioning

confidence: 99%

Effect of Exposure to Mixture of Heavy Metals Arsenic, Cadmium and Lead on Reproductive Function and Oxidative Stress in Female Rats

Choudhuri

Bhattacharjee

2017

IJTPR

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Background : Toxicological consequences arising from exposure to mixtures of heavy metals especially at low, chronic and environmentally relevant doses are poorly recognised. In the present study, we evaluated effects of chronic exposure to combinations of three metals arsenic (As), cadmium (Cd) and lead (Pb) present frequently in drinking water on reproductive function and oxidative damage caused to reproductive organs of female rats. Method : Female rats were exposed to mixture of metals (As, Cdand Pb) for 90 consecutive days. The gain in body weight and weight of reproductive organs were recorded following autopsy on 91 stday. The oestrus cycle were monitored during entire treatment period. Numbers of corpora lutea, implantation sites, live fetus and survival of the fetus were evaluated in rats mated successfully with untreated male after completion of their respective treatment. Ovarian cholesterol, protein, ascorbic acid and enzyme Δ 5 -3β HSD levels were estimated. Serum levels of steroid hormones oestrogen and progesterone were estimated. Histopathological picture of both ovary and uterus were assessed. Levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidise (GPX) activity, amount of reduced glutathione (GSH) and malondyaldehyde (MDA) in blood, ovary and uterus were measured as biomarkers of oxidative stress. Results : The treated rats showed reduced body weight gain and reduction in the weight of ovary and uterus. Oestrus cycle was disrupted with continuous diestrous in treated animals. Number of corpora lutea, implantation sites and live fetus and the survival of fetus evaluate were reduced significantly in treated groups. The levels of ovarian cholesterol and ascorbic acid increased in treated rats with decrease Δ5 -3β HSD level. There was reduction in serum level of both the ovarian steroid hormones oestrogen and progesterone. The protein levels did not differ between the groups. There was a significant increase in levels of MDA and decrease in levels of all the antioxidant enzymes in treated group. Conclusion : The results revealed there was disruption to reproductive functions with decrease in stereoidogenic activity and associated oxidative stress in female rats treated with combination of mixture of metals (Cd, As and Pb) at low dose for 90 consecutive days.

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Oxidative Stress of Cadmium-Induced Ovarian Rat Toxicity

Cited by 6 publications

References 17 publications

Curcumin protects the testis against cadmium-induced histopathological damages and oxidative stress in mice

Curcumin protects the testis against cadmium-induced histopathological damages and oxidative stress in mice

Metabolic depletion of synaptosomal enzymes linked with neurotoxicity and ovarian dysfunction by phenolic antioxidants of Croton zambsicus leaves in rats exposed to chronic mixture of anthropogenic toxicant

Effect of Exposure to Mixture of Heavy Metals Arsenic, Cadmium and Lead on Reproductive Function and Oxidative Stress in Female Rats

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