Chronic Allergic Contact Dermatitis Due to Chlorhexidine

Delayed-type drug eruption to phenazopyridine (pyridium) confirmed with patch testing

“…This is likely attributable to its rarity as well as an underdiagnosed phenomenon—especially as phenazopyridine is often prescribed together with antibiotics and hypersensitivity reactions are often empirically attributed to the accompanying antibiotic (such as in this case). Both patch and intradermal testing are useful tools in investigating delayed-type drug hypersensitivity reactions [ 3 4 5 ]. In this case, we chose to perform PT due to its higher specificity and lower risk of systemic reactivation.…”

Contact Dermatitis After Hip Arthroscopic Surgery

“…Watts et al 7 published a case report of an operating room nurse who presented with chronic allergic contact dermatitis to the hands. Patch testing revealed sensitivity to chlorhexidine digluconate, and her symptoms resolved after 3 weeks of avoiding chlorhexidine compounds.…”

It is not always chlorhexidine: Identification of benzoxonium chloride and lauramine oxide as culprit allergens in a popular antiseptic in Switzerland

“…Chlorhexidine is one of the most frequently used antiseptics 1 in this regard, yet may provoke both type I and IV allergies. [1][2][3][4][5] In Switzerland, and also Israel, a colourless spray that, besides chlorhexidine (0.5%), also contains benzoxonium chloride (0.1%) (CAS 19379-90-9) and lauramine oxide (CAS 1643-20-5) (company proprietary undisclosed %), has become very popular in the treatment of small wounds. 6 The first compound belongs to the group of quaternary ammonium salts (QUATS) that are widely used as antiseptics and disinfectants because of their high antimicrobial activity, low toxicity and thermal stability.…”

“…Antiseptics are often applied to treat small wounds or for field cleansing prior to minor interventions, such as ear piercing. Chlorhexidine is one of the most frequently used antiseptics 1 in this regard, yet may provoke both type I and IV allergies 1–5 . In Switzerland, and also Israel, a colourless spray that, besides chlorhexidine (0.5%), also contains benzoxonium chloride (0.1%) (CAS 19379‐90‐9) and lauramine oxide (CAS 1643‐20‐5) (company proprietary undisclosed %), has become very popular in the treatment of small wounds 6 .…”