2013
DOI: 10.4196/kjpp.2013.17.5.393
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Chronic Administration of Baicalein Decreases Depression-Like Behavior Induced by Repeated Restraint Stress in Rats

Abstract: Baicalein (BA), a plant-derived active flavonoid present in the root of Scutellaria baicalensis, has been widely used for the treatment of stress-related neuropsychiatric disorders including depression. Previous studies have demonstrated that repeated restraint stress disrupts the activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression. The behavioral and neurochemical basis of the BA effect on depression remain unclear. The present study used the forced swimming test (FST) and chang… Show more

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Cited by 53 publications
(54 citation statements)
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“…The open field locomotor activity test (OFT) was conducted in clear black Plexiglas boxes (40 × 40 × 40 cm) equipped with the video-based Ethovision System (Nol-dus, Wageningen, The Netherlands), as described previously [13]. Mice were initially placed in the corner of the apparatus, and total distance moved was recorded for 10 min.…”
Section: Open Field Locomotor Activity Test (Oft)mentioning
confidence: 99%
“…The open field locomotor activity test (OFT) was conducted in clear black Plexiglas boxes (40 × 40 × 40 cm) equipped with the video-based Ethovision System (Nol-dus, Wageningen, The Netherlands), as described previously [13]. Mice were initially placed in the corner of the apparatus, and total distance moved was recorded for 10 min.…”
Section: Open Field Locomotor Activity Test (Oft)mentioning
confidence: 99%
“…Also, the myricetin-alone treatment group spent more time in the target quadrant similar to the vehicle group. There were no variations in the average speed [F (3,24) = 0.517, P > 0.05, n = 7] and travel distance [F (3,24) = 0.373, P > 0.05, n = 7] in the probe trials ( Fig. 3c-d).…”
Section: Effects Of Myricetin On Spatial Learning At the Training Sesmentioning
confidence: 82%
“…Myr, myricetin. (3,20) = 55.67, ***P < 0.001; n = 6], and the myricetin + stress group [F (3,24) = 44.7, ***P < 0.001; n = 7] showed strong spatial bias for the target quadrant compared with the other quadrants. Myr, myricetin.…”
Section: Effects Of Myricetin On Plasma Acth Levelsmentioning
confidence: 97%
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“…21 Mice were initially placed in the corner of the apparatus, and total distance moved was recorded for 10 min. The horizontal locomotor activity is expressed in terms of the total ambulatory distance (cm).…”
Section: Open Field Testmentioning
confidence: 99%