Chelidonic acid evokes antidepressant-like effect through the up-regulation of BDNF in forced swimming test

Jeong, Hyun‐Ja; Yang, Sung–Chae; Kim, Hee-Yun; Kim, Na-Rae; Jang, Jae-Bum; Kim, Hyung-Min

doi:10.1177/1535370216642044

Cited by 9 publications

(8 citation statements)

References 51 publications

(75 reference statements)

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“…Male BALB/c mice (Dae-Han Experimental Animal Center, Daejon, Korea) and STAT6-/-mice (Stock No: 002828|Stat6 -Jackson Laboratory, Bar Harbor, ME, USA) aged 4 weeks old were used in accordance with previous reports [11,12]. Experiments were initiated after at least 1 week to adapt to the laboratory environment.…”

Section: Animalsmentioning

confidence: 99%

Functions of the Signal Transducer and Activator of Transcription 6 in a Behavioral Animal Model of Depression

et al. 2018

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Aims: Depression is one of the most common inflammatory and mental disorders. Signal transducer and activator of transcription 6 (STAT6) plays a crucial role in the pathology of mental disorders as well as inflammatory diseases. Methods: Here we determined the role of STAT6 in the pathogenesis of depression using STAT6-deficient mice in a forced swimming test. Results: The immobility time was significantly decreased in STAT6-deficient mice compared to wild-type mice without alteration of locomotor activity. STAT6-deficient mice exhibited a significantly enhancing dopamine and 5-hydroxytryptamine (5-HT, serotonin) in brain. In addition, the expression of serotonin transporter in the hippocampus was markedly downregulated in STAT6-deficient mice. These results provide the first evidence that STAT6 affects depressive-like behavior through downregulating monoamines, including dopamine and 5-HT in the hippocampus of brain. Conclusions: In conclusion, identification of STAT6 signaling pathways on depression might open new perspectives for antidepressant therapies.

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Section: Animalsmentioning

confidence: 99%

Functions of the Signal Transducer and Activator of Transcription 6 in a Behavioral Animal Model of Depression

et al. 2018

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“…In addition, other studies have shown that BDNF plays an important role in the pathogenesis of severe depression [ 34 , 36 , 37 ]. BDNF is involved in the survival of neurons and the regeneration of dopamine, 5-HT, and cholinergic neurons in the central nervous system, and it is also a molecular marker of synaptic plasticity [ 38 ]. Exogenous BDNF has antidepressant effect in the animal model of depression [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats

Luo

Fan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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This study aimed to investigate the therapeutic effects of candesartan combined with music therapy on diabetic retinopathy with depression and to assess the molecular mechanisms. Associated animal model of diabetes mellitus and depression was established in rats. Pathological changes in the hippocampus were detected by haematoxylin eosin (H&E) staining. Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) was used to detect retinal cell apoptosis. Angiotensin II (Ang II) in peripheral blood and neurotransmitters, including serotonin (5-HT), dopamine (DA), and norepinephrine (NE) in the hippocampus, was measured by enzyme linked immunosorbent assay (ELISA). Fluorescence quantitative PCR and western blotting were used to detect the expression of brain-derived neurotrophic factor (BDNF) and c-fos in the hippocampus. Our data showed that chromatin aggregation and cytoplasmic vacuolation were observable in the hippocampal cells of the rats in the model group, while candesartan and music therapy could reduce morphological changes in the hippocampus of diabetic rats with depression. Compared with the control group, the apoptosis of retinal cells was significantly higher, the contents of 5-HT, DA, and NE in the hippocampus were significantly lower, Ang II level in peripheral blood was significantly higher, and the expression of BDNF and c-fos in the hippocampus decreased significantly in the model group. By contrast, candesartan or candesartan + music therapy ameliorated the changes in retina cell apoptosis, reduction of neurotransmitters, increase in AII, and the expression of c-fos and BDNF. Especially, music therapy further improved the effects of candesartan on retina cell apoptosis and neurotransmitter release in diabetic retinopathy rats with depression. In conclusion, candesartan and music therapy have an additive effect in DM with both visual impairment and depression, which might serve a potential alternative treatment for this complex disease.

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“…The dose of chelidonic acid was selected based on previously reported pharmacological activities and also verified by determining the LD50. [3,6,18,19] All the animals were given regular pellet food and free access to water throughout the study. Animals were constantly monitored for signs of toxicity and death.…”

Section: Pathologymentioning

confidence: 99%

Effects of Acute and Repeated Dose Toxicity Profiling of Chelidonic Acid in Rats: in Silico and in Vivo Evidence

Khairnar,

Kulkarni,

Murugesan

et al. 2023

Chemistry & Biodiversity

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Chelidonic acid is a phytoconstituent found in rhizomes of the perennial plant celandine. The current study aims to evaluate the acute and repeated dose oral toxicity study of chelidonic acid as per the OECD guidelines 425 and 407. The pharmacokinetic and toxicity profile of chelidonic acid was predicted using online servers and tools. A single dose of chelidonic acid (2000 mg/kg) was administered to female Wistar rats in an acute toxicity study, and the animals were monitored for 14 days. We studied the toxicity profile of chelidonic acid at 10, 20, and 40 mg/kg doses in Wistar rats for repeated dose toxicity (28 days). Clinical biochemistry, haematological, and urine parameters were estimated. A gross necropsy and histopathology were performed. A single oral dose of chelidonic acid (2000 mg/kg) showed no signs of toxicity or mortality. The Administration of chelidonic acid showed no significant alterations in haematological, biochemical, and urine parameters. The histopathology showed normal structure and architecture in all the vital organs. A gross necropsy of vital organs showed no signs of toxicity. The chelidonic acid was found to be safe at all selected dose levels in the acute and repeated dose toxicity study in rats.

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Chelidonic acid evokes antidepressant-like effect through the up-regulation of BDNF in forced swimming test

Cited by 9 publications

References 51 publications

Functions of the Signal Transducer and Activator of Transcription 6 in a Behavioral Animal Model of Depression

Functions of the Signal Transducer and Activator of Transcription 6 in a Behavioral Animal Model of Depression

Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats

Effects of Acute and Repeated Dose Toxicity Profiling of Chelidonic Acid in Rats: in Silico and in Vivo Evidence

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