Protective effects of myricetin on chronic stress-induced cognitive deficits

Abstract

The aim of the present study is to investigate the possible effects of chronic administration of myricetin, a natural flavonoid, on chronic stress-induced learning and memory deficits in mice. The mice were restrained daily 4 h/day for 21 days in well-ventilated plexiglass tubes without access to food and water. These animals were injected with myricetin or vehicle 40 min before each restraint stress over a period of 21 days. Then, spatial learning and memory of the mice were evaluated by the Morris water maze task. We did not observe a significant difference in the escape latency in mice subjected to repeated restraint stress, which indicates that learning ability was not affected by restraint stress. However, the spatial memory ability was significantly impaired in the repeatedly restrained mice. Myricetin administration specifically increased the time spent in the target quadrant in mice exposed to chronic stress in the probe trial as tested in the Morris water maze task. Further studies showed that myricetin treatment decreased plasma adrenocorticotrophic hormone levels of those mice subjected to repeated restraint stress. The effect of myricetin on the levels of brain-derived neurotrophic factor (BDNF) in hippocampus was also investigated. The result showed that myricetin normalized the decreased BDNF levels in mice subjected to repeated restraint stress. These findings provide more evidence that chronic administration of myricetin improves spatial memory in repeatedly restrained mice and BDNF signaling in the hippocampus may be involved in the protective effects of myricetin.

Effects of MicroRNA-592-5p on Hippocampal Neuron Injury Following Hypoxic-Ischemic Brain Damage in Neonatal Mice - Involvement of PGD2/DP and PTGDR

“…Differences between two groups were compared by the independent-sample t test. Comparisons among multiple groups were conducted by a one-way ANOVA, and pair-comparisons were determined with the Student-Newman-Keuls test [20]. P < 0.05 was considered to be significant.…”

“…If the mice were unable to find the platform within 60 s, they were guided to it so that they could remember its location. The mice were trained for 4 d (6 times each day), and the median escape latency of each group was used for assessments of mice’s spatial learning and memory capacity (N = 15) [20]. …”

The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice

“…Quercetin inhibits Aβ production via α-secretase up-regulation 66) and β-secretase 67) and γ-secretase inhibition, 68) inhibits Aβ aggregation, 69) promotes Aβ clearance, 70) protects nerve cells from Aβ-induced cytotoxicity, 71,72) and activates the CREB/ BDNF pathway. 73) Myricetin inhibits Aβ production via α-secretase activation and β-secretase inhibition, 74) inhibits Aβ aggregation, 8,75) and promotes an increase in BDNF. 76) Taxifolin inhibits Aβ production via β-secretase up-regulation, 77) inhibits Aβ aggregation, 78,79) and inhibits AChE activity.…”

Inhibitory Effects of Myricetin on Lipopolysaccharide-Induced Neuroinflammation

“…Furthermore, in mice subjected to restraint stress to induce cognitive deficits and depression, myricetin improved spatial memory and depression-like behavior. Myricetin also normalized the decreased brain-derived neurotrophic factor (BDNF) levels observed in the hippocampus [13,14]. Myricetin was also found to protect 1-methyl-4-phenylpyridinium (MPP+)-treated MES23.5 dopaminergic cells-which exhibit similar properties to primary neurons originating in the substantia nigra, a lesion of PD-by inhibiting MAPK kinase and c-Jun N-terminal kinase (JNK) activation and having an anti-oxidative role [15].…”