Chromosome Localization and Genomic Structure of the KiSS-1 Metastasis Suppressor Gene (KISS1)

West, Ande; Vojta, Patrick J.; Welch, Danny R.; Weissman, Bernard E.

doi:10.1006/geno.1998.5566

Cited by 175 publications

(112 citation statements)

References 5 publications

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“…This gene consists of three exons, two of which are partially translated exons (exons 2 and 3), which give rise to a 145-amino acid precursor peptide [10]. The precursor peptide is then cleaved to 54 (68-121) amino acids in length, which can be truncated further to 14 (108-121), 13 (109-121) or 10 (112-121) amino acid carboxyl-terminal fragments.…”

Section: (2) the Kiss1 Gene Analysismentioning

confidence: 99%

KISS1 gene analysis in Korean girls with central precocious puberty: a polymorphism, p.P110T, suggested to exert a protective effect

Lee

Hwang

2010

Endocr J

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Section: (2) the Kiss1 Gene Analysismentioning

confidence: 99%

KISS1 gene analysis in Korean girls with central precocious puberty: a polymorphism, p.P110T, suggested to exert a protective effect

Lee

Hwang

2010

Endocr J

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“…9 -11 The KISS1 gene maps to chromosome region 1q32, 12 and it can be regulated by genes located on chromosome 6. 10,11,13 The highest concentrations of the KISS1 protein are found in the placenta, although it is also expressed in the central nervous system, testis, ovary, pancreas, and intestine. 9 processed into kisspeptins of several sizes.…”

mentioning

confidence: 99%

KISS1 Methylation and Expression as Tumor Stratification Biomarkers and Clinical Outcome Prognosticators for Bladder Cancer Patients

Cebrián

Fierro

Orenes‐Piñero

et al. 2011

The American Journal of Pathology

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KISS1 is a metastasis suppressor gene that is lost in several malignancies, including bladder cancer. We tested the epigenetic silencing hypothesis and evaluated the biological influence of KISS1 methylation on its expression and clinical relevance in bladder cancer. KISS1 hypermethylation was frequent in bladder cancer cells analyzed by methylation-specific PCR and bisulfite sequencing and was associated with low gene expression, being restored in vitro by demethylating azacytidine. Hypermethylation was also frequently observed in a large series of bladder tumors (83.1%, n ‫؍‬ 804). KISS1 methylation was associated with increasing stage (P ‫؍‬ 0.001) and tumor grade (P ‫؍‬ 0.010). KISS1 methylation was associated with low KISS1 transcript expression by quantitative RT-PCR (P ‫؍‬ 0.037). KISS1 transcript expression was also associated with histopathological tumor stage (P < 0.0005). Low transcript expression alone (P ‫؍‬ 0.003) or combined with methylation (P ‫؍‬ 0.019) was associated with poor disease-specific survival (n ‫؍‬ 205).KISS1 transcript expression remained an independent prognosticator in multivariate analyses (P ‫؍‬ 0.017). KISS1 hypermethylation was identified in bladder cancer, providing a potential mechanistic explanation (epigenetic silencing) for the observed loss of KISS1 in uroepithelial malignancies. Associations of KISS1 methylation and its expression with histopathological variables and poor survival suggest the utility of incorporating KISS1 measurement using paraffin-embedded material for tumor stratification and clinical outcome prognosis of patients with uroepithelial neoplasias.

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“…It was named after the famous Hershey's chocolate 'kisses' as it was first discovered in Hershey, Pennsylvania, USA. The KiSS1 gene is located on human chromosome 1 (1q32), which initially produces a 145 amino acid precursor peptide (prepro-kisspeptin), which is cleaved to 54 amino acid protein (kisspeptin-54, Kp-45, formerly called metastin) [12,13]. Kp-54 may be further cleaved to lower molecular weight forms of kisspeptins, Kp-14, Kp-13, and Kp-10, sharing a common C-terminal sequence of arginine-phenylalanine-NH2 motif that is sufficient to fully activate GPR54.…”

Section: Discovery Of Kiss1/kisspeptin/gpr54mentioning

confidence: 99%

Rola sygnalizacji kisspeptyny w osi podwzgórze–przysadka–nadnercza — aktualna perspektywa

Javed

Qamar

Sathyapalan

2015

Endokrynologia Polska

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The discovery of kisspeptins in the recent past remoulded current understanding of the neuroendocrine axis relating to the regulation of human puberty and reproduction. Kisspeptins have been recognised to act upstream of GnRH and have been shown to play a vital role in the control of the hypothalamic-pituitary-gonadal axis via regulation of gonadotrophin secretion, onset of puberty, and control of fertility. KNDy (kisspeptin/neurokinin-B/dynorphin) neurons have been suggested to modulate GnRH pulsatile secretion, which is required to support reproductive function in both sexes. They have also been involved in mediating both positive and negative sex steroid feedback signals to GnRH neurons and serve as a vital connection between reproduction and metabolic status of the body. When kisspeptin is administered to healthy humans, and in patients with reproductive disorders, it strongly and directly stimulates GnRH and subsequent LH secretion and enhances LH pulse frequency. These observations suggest that kisspeptins are a potential novel therapeutic approach for treating disorders with either pathologically reduced or augmented gonadotrophins pulsatile secretion and is currently a focus of translational research. Kisspeptins have also been identified in several peripheral reproductive organs, indicating their role in modulation of ovarian function, embryo implantation, and placentation, but a great deal of work remains to be done to explore further in this regard, and the evidence is only available from studies done on animal models. In this review we will mainly focus on current available evidence related to the role of kisspeptins in controlling GnRH pulse frequency, specifically their role in puberty, fertility, and reproduction. We will also be appraising other factors that regulate the kiSS1/Kisspeptin/GPR-54 system. StreszczenieOdkrycie kisspeptyn, które miało miejsce całkiem niedawno, odmieniło obecne rozumienie osi neuroendokrynnej, związanej z regulacją okresu dojrzewania i rozrodu. Odkryto, że kisspeptyny działają przed GnRH i odgrywają istotną rolę w kontroli osi podwzgórze-przysadka-nadnercza poprzez regulację wydzielania gonadotropiny, rozpoczęcia okresu dojrzewania oraz kontroli płodności. Zasugerowano, że komórki KNDy (kisspeptyna/neurokinina-B/dynorfina) modulują pulsacyjne uwalnianie GnRH, wymagane, aby wspomagać funkcję rozrodczą u obu płci. Komórki te są również zaangażowane w przekazywanie zarówno pozytywnych, jak i negatywnych sygnałów hormonów płciowych do neuronów GnRH, a także stanowią kluczowe połączenie między reprodukcją i stanem metabolicznym ciała. Kiedy kisspeptyna jest podawana jednostkom zdrowym i pacjentom z zaburzeniami płodności, silnie i bezpośrednio stymuluje GnPH i dalsze uwalnianie LH oraz poprawia częstotliwość impulsów LH. Obserwacje te przedstawiają kisspeptyny jako nowe potencjalne terapeutyczne podejście w leczeniu zaburzeń patologicznie obniżonego lub zwiększonego pulsacyjnego uwalniania gonadotropin i obecnie stanowi główny punkt zainteresowania badań przekładaj...

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Chromosome Localization and Genomic Structure of the KiSS-1 Metastasis Suppressor Gene (KISS1)

Cited by 175 publications

References 5 publications

KISS1 gene analysis in Korean girls with central precocious puberty: a polymorphism, p.P110T, suggested to exert a protective effect

KISS1 gene analysis in Korean girls with central precocious puberty: a polymorphism, p.P110T, suggested to exert a protective effect

KISS1 Methylation and Expression as Tumor Stratification Biomarkers and Clinical Outcome Prognosticators for Bladder Cancer Patients

Rola sygnalizacji kisspeptyny w osi podwzgórze–przysadka–nadnercza — aktualna perspektywa

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