Rola sygnalizacji kisspeptyny w osi podwzgórze–przysadka–nadnercza — aktualna perspektywa

Javed, Zeeshan; Qamar, Unaiza; Sathyapalan, Thozhukat

doi:10.5603/ep.2015.0066

Cited by 27 publications

(3 citation statements)

References 186 publications

(305 reference statements)

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“…In mammals, ERα (ESR1) plays crucial roles in estrogen-dependent GnRH/LH secretion because kisspeptin neurons expressing ESR1 in the arcuate nucleus (ARC) mediate negative feedback regulation by estrogens 35 . However, recent studies strongly suggest that neither kisspeptin, GnRH, nor LH is required for folliculogenesis in teleosts, and FSH is absolutely responsible for folliculogenesis 17,18,32,34,36,37 .…”

Section: Discussionmentioning

confidence: 99%

Gene knockout analysis reveals essentiality of estrogen receptor β1 (Esr2a) for female reproduction in medaka

Kayo

Zempo

Tomihara

et al. 2019

Sci Rep

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In vertebrates, sex steroids play crucial roles in multiple systems related to reproduction. In females, estrogens and their receptor estrogen receptor (ER or Esr) play indispensable roles in the negative sex steroid feedback regulation of pituitary gonadotropin secretion, which prevents excessive development of ovarian follicles. However, the mechanism of this feedback regulation of a gonadotropin, follicle stimulating hormone (FSH), which is essential for folliculogenesis throughout vertebrates, is poorly understood. In the present study, we generated knockouts of all subtypes of nuclear estrogen receptors in a model teleost medaka, which is suitable for the study of endocrine control and behavioral assays, and analyzed fertility, behavior and functionality of estrogen feedback in each knockout line. Among the estrogen receptors, we revealed that an estrogen receptor Esr2a plays an essential role in this feedback regulation. In addition to this, we also found that esr2a −/− females showed oviduct atresia, which causes complete infertility. Interestingly, esr2a −/− females showed apparently normal sexual behavior but without oviposition in response to male courtship. This phenotype indicates that physical readiness and motivation of sexual behavior is independently controlled.

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Section: Discussionmentioning

confidence: 99%

Gene knockout analysis reveals essentiality of estrogen receptor β1 (Esr2a) for female reproduction in medaka

Kayo

Zempo

Tomihara

et al. 2019

Sci Rep

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“…For example, the suppression of GnRH secretion and consequently reduced estrogen level leading to lactational anoestrous is characteristic in mothers (McNeilly, 2006). The central common pathways for the regulation of GnRH neurons are kisspeptin neurons (Clarke et al, 2015; Uenoyama et al, 2016) located in the anteroventral periventricular and arcuate nuclei (Javed et al, 2015). Lactational anoestrus is primarily driven by the suckling stimulus during the first half of lactation and by negative energy balance during its second half (Tsukamura and Maeda, 2001) mediated by the kisspeptin system (Smith et al, 2010; Topaloglu et al, 2010).…”

Section: Additional Maternal Adaptations Of the Brain And Their Pomentioning

confidence: 99%

Thalamic integration of social stimuli regulating parental behavior and the oxytocin system

Dobolyi

Cservenák²,

Young

2018

Frontiers in Neuroendocrinology

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Critically important components of the maternal neural circuit in the preoptic area robustly activated by suckling were recently identified. In turn, suckling also contributes to hormonal adaptations to motherhood, which includes oxytocin release and consequent milk ejection. Other reproductive or social stimuli can also trigger the release of oxytocin centrally, influencing parental or social behaviors. However, the neuronal pathways that transfer suckling and other somatosensory stimuli to the preoptic area and oxytocin neurons have been poorly characterized. Recently, a relay center of suckling was determined and characterized in the posterior intralaminar complex of the thalamus (PIL). Its neurons containing tuberoinfundibular peptide 39 project to both the preoptic area and oxytocin neurons in the hypothalamus. The present review argues that the PIL is a major relay nucleus conveying somatosensory information supporting maternal behavior and oxytocin release in mothers, and may be involved more generally in social cue evoked oxytocin release, too.

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“…Recent data from experiments on mammals showed that kisspeptin is a component of the pulse generator for GnRH (and in consequence LH) secretion (Ezzat, Pereira, & Clarke, 2015;Han, McLennan, Czieselsky, & Herbison, 2015, Javed, Qamar, & Sathyapalan, 2015Kunimura, Iwata, Ishigami, & Ozawa, 2017). In humans (women) endogenous pulsatile release of kisspeptin was demonstrated (Meczekalski, Katulski, PodfigurnaStopa, Czyzyk, & Genazzani, 2016) and the pulses of kisspeptin were temporally coupled with LH pulses.…”

Section: Introductionmentioning

confidence: 99%

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Mikolajczyk¹,

Gosiewski²,

Chyb³

et al. 2018

Turk. J. Fish. Aquat. Sci.

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Kisspeptin plays a critical role in the control of reproduction and puberty onset in vertebrates, fish including. To demonstrate the pattern of LH secretory responses [spontaneous and stimulated by GnRH analogue (Des Gly 10 , D-Ala 6 ethylamide LHRH)] to single, intraperitoneal injection of human kisspeptin [metastin (45-54) amide], blood samples from mature Prussian carp females (at the time of gonad recrudescence and natural spawning) were collected at 5, 10, 15 and 30 minutes after injection. To test the influence of dopamine on kisspeptin action on LH release, the dopamine antagonistpimozide -was used together with kisspeptin and GnRH analogue. At the time of gonad recrudescence kisspeptin alone had no effect on LH secretion. At the time of natural spawning the transient increase of LH levels at 10 th minute post-injection was observed. Also the combination of kisspeptin and GnRHa increased LH levels in comparison to control fish at 10, 15 and 30 minutes after injections and at 10 th minute kisspeptin potentiated stimulatory effects of GnRHa. No influence of kisspeptin on the spontaneous, as well as GnRHa-stimulated LH release was observed in pimozide-treated fish. Presented data suggest that the short-term response to kisspeptin is dependent on the stage of gonadal maturity.

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Rola sygnalizacji kisspeptyny w osi podwzgórze–przysadka–nadnercza — aktualna perspektywa

Cited by 27 publications

References 186 publications

Gene knockout analysis reveals essentiality of estrogen receptor β1 (Esr2a) for female reproduction in medaka

Gene knockout analysis reveals essentiality of estrogen receptor β1 (Esr2a) for female reproduction in medaka

Thalamic integration of social stimuli regulating parental behavior and the oxytocin system

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