Chromosome 16q, eosinophilia, and leukemia

Neri, Giovanni; Daniel, Art; Hammond, Neel

doi:10.1016/0165-4608(85)90203-1

Cited by 22 publications

(7 citation statements)

References 5 publications

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“…These abnormalities included t(5;12)(q33;p13), 20 inv16(p13q22), [17][18][19] and other abnormalities in chromosomes 7 or 16. 9,23,32,33 The t(5;12)(q33;p13) abnormality is less common but appears to be relevant for the pathogenesis of the eosinophilia.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia

Maekawa

Handa

Yokohama

et al. 2003

Blood

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By retrospectively analyzing 288 patients with de novo myelodysplastic syndrome (MDS), we sought to determine the prevalence and clinical characteristics of bone marrow eosinophilia and basophilia that were detected at presentation. Bone marrow eosinophilia and basophilia were defined as a differential count of each cell type exceeding 5.0% and 1.0%, respectively. Of 288 patients with MDS, 36 (12.5%) fulfilled this criterion for bone marrow eosinophilia (MDS-Eos); 34 patients (11.8%) showed basophilia (MDS-Bas), and 11 (3.8%) satisfied both criteria (MDSEosBas). The remaining 229 patients had neither eosinophilia nor basophilia in their bone marrow (MDS ؊/؊ ) at presentation. Cytogenetic analysis was carried out on unstimulated bone marrow cells obtained from 264 patients. When the cytogenetic categorization of the IPSS (International Prognostic Scoring System) for MDS was applied, significantly higher numbers of MDS-Eos and MDS-Bas patients had chromosomal abnormalities carrying intermediate or poor prognosis, compared with the MDS ؊/؊ patients. Specific chromosomal abnormalities and complex karyotypes were associated with MDS-Eos and/or MDS-Bas. In accordance with these results, the overall survival rate was significantly lower, and the evolution to acute myelogenous leukemia (AML) occurred more frequently in the MDS-Eos and MDSBas than in the MDS ؊/؊ patients. Multivariate analysis demonstrated that bone marrow basophilia was an independent risk factor for evolution to AML. Our study indicates that bone marrow eosinophilia and basophilia in patients with MDS predict a poorer prognosis. (Blood. 2003;

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Section: Discussionmentioning

confidence: 99%

“…In previous reports, bone marrow eosinophilia or basophilia in MDS was observed in patients having complex karyotypes, 9,11 a chromosome 7 abnormality, 12 i(17q), 13 t(6;9), [14][15][16] inv16, [17][18][19] or t(5;12). 20 In our study, t(6;9) was observed in only 2 patients and neither inv16 nor t(5;12) was detected.…”

Section: Cytogeneticsmentioning

confidence: 99%

Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia

Maekawa

Handa

Yokohama

et al. 2003

Blood

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“…One of these three adult cases was a male patient with the diagnosis of myelodysplastic syndrome. In this patient, the translocation of t(3;16)(q21;q22) was found in the complex karyotype, as in our case [5]. The other two cases were female patients and they were diagnosed with acute myeloid leukemia that developed after acute myelomonocytic leukemia and primary tumor mantle cell lymphoma, respectively.…”

Section: To the Editormentioning

confidence: 50%

Aggressive Clinicopathological Course of Myeloma with t(3;16) (q21;q22) Cytogenetic Abnormality

Bozkurt

Okay

Haznedaroğlu

2019

Tjh

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“…Few cases of translocations involving chromosomes 3 and 16 have been reported. One patient presented with MDS, bone marrow eosinophilia, ischemia of the right leg and a non-constitutional 3;16 translocation: t(3;16)(q21;q22) [58]. However, the platelet count was not reported, and the leg ischemia was considered an unrelated symptom.…”

Section: Discussionmentioning

confidence: 99%

Acute myelogenous leukemia associated with extreme symptomatic thrombocytosis and chromosome 3q translocation: Case report and review of literature

et al. 2002

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Chromosome 16q, eosinophilia, and leukemia

Cited by 22 publications

References 5 publications

Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia

Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia

Aggressive Clinicopathological Course of Myeloma with t(3;16) (q21;q22) Cytogenetic Abnormality

Acute myelogenous leukemia associated with extreme symptomatic thrombocytosis and chromosome 3q translocation: Case report and review of literature

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