Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia

Abstract

By retrospectively analyzing 288 patients with de novo myelodysplastic syndrome (MDS), we sought to determine the prevalence and clinical characteristics of bone marrow eosinophilia and basophilia that were detected at presentation. Bone marrow eosinophilia and basophilia were defined as a differential count of each cell type exceeding 5.0% and 1.0%, respectively. Of 288 patients with MDS, 36 (12.5%) fulfilled this criterion for bone marrow eosinophilia (MDS-Eos); 34 patients (11.8%) showed basophilia (MDS-Bas), and 11 (3.8%) satisfied both criteria (MDSEosBas). The remaining 229 patients had neither eosinophilia nor basophilia in their bone marrow (MDS ؊/؊ ) at presentation. Cytogenetic analysis was carried out on unstimulated bone marrow cells obtained from 264 patients. When the cytogenetic categorization of the IPSS (International Prognostic Scoring System) for MDS was applied, significantly higher numbers of MDS-Eos and MDS-Bas patients had chromosomal abnormalities carrying intermediate or poor prognosis, compared with the MDS ؊/؊ patients. Specific chromosomal abnormalities and complex karyotypes were associated with MDS-Eos and/or MDS-Bas. In accordance with these results, the overall survival rate was significantly lower, and the evolution to acute myelogenous leukemia (AML) occurred more frequently in the MDS-Eos and MDSBas than in the MDS ؊/؊ patients. Multivariate analysis demonstrated that bone marrow basophilia was an independent risk factor for evolution to AML. Our study indicates that bone marrow eosinophilia and basophilia in patients with MDS predict a poorer prognosis. (Blood. 2003;

Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries

“…13 Accordingly, low percentages of RARS and CMML were found in Asian countries (Table 4), 3,5,11,14 since these two subtypes mostly occur in older patients, as also shown in our series. Apart from the ethnic and demographic reason for this disparity, we believe that environmental factors, including chemical contamination and infectious agents may also play a role.…”

Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes

“…Although there was no difference in the distribution of cytogenetic subgroups according to IPSS, the frequency of chromosomal abnormalities was lower in Japanese patients with RA; notably that of isolated del (5q) was lower in Japan. Toyama et al 18 and Matsushima et al 20 reported that Japanese patients with MDS had a lower frequency of isolated del (5q) than Western reports (2.0% and 1.5%, respectively). Morel et al 21 and Greenberg et al 5 reported that the frequencies of isolated del (5q) in all MDS cases were 4.7% and 5.9%, respectively.…”

Trisomy 8 is the Most Frequent Cytogenetic Abnormality in de novo Myelodysplastic Syndrome in China

“…Cytogenetic abnormalities whichhavepowerfulprognosticimpactinMDSarefoundin morethan50%ofMDSpatients [3][4][5].Severalreportscompare the chromosome abnormalities of MDS patients from Eastern and Western countries [6][7][8][9][10][11]. The most common cytogeneticaberrationforWesternersorAfricanswas-5/5q- [3,[12][13][14][15].Ontheotherhand,Lietal.…”