Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries

Chen, B; Wl, Zhao; Jin, Jiye; Yq, Xue; X, Cheng; Xt, Chen; Cui, Jiantao; Chen, Zhi Min; Cao, Qi; Yang, Guang; Yao, Yihong; Hl, Xia; Jh, Tong; Jm, Li; Chen, J; Sm, Xiong; Zx, Shen; Waxman, Samuel; Chen, Z; Sj, Chen

doi:10.1038/sj.leu.2403688

Cited by 105 publications

(104 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies suggest different genetic or environmental backgrounds between Asian and Western MDS populations. 24,25 According to the recent report by Haase et al, 28 isolated del(5q) was seen in 14%, del(5q) with one additional abnormality in 5%, and complex abnormalities including del(5q) were seen in 11% of patients with clonal abnormalities. In the Korean study, isolated del(5q) was seen in 1.7% of the patients.…”

Section: Discussionmentioning

confidence: 99%

Myelodysplastic syndrome with chromosome 5 abnormalities: a nationwide survey in Japan

et al. 2008

View full text Add to dashboard Cite

Chromosome 5 abnormalities, deletion of the long arm of chromosome 5 (del(5q)) or monosomy 5 (À5), arise in about 10% of myelodysplastic syndromes (MDS), either as the sole cytogenetic abnormality or as part of complicated karyotype, and has distinct clinical implications for MDS. However, the prognostic factors of MDS patients with chromosome 5 abnormalities are not determined yet. In this study, 183 Japanese MDS patients with chromosome 5 abnormalities were analyzed. Estimated incidence of del(5q) and 5q-syndrome among MDS patients was 8.4 and 1.3%, respectively. Significant shorter overall survival (OS) and leukemia-free survival (LFS) were observed in À5 patients than del(5q) patients. Among del(5q) patients, addition of monosomy 7 or complex karyotype with more than three abnormalities were significantly related to shorter OS.LFS of del(5q) patients was divided into two risk groups by international prognostic scoring system (IPSS): low/intermediate (Int)-1 and Int-2/high groups. LFS sorted by World Health Organization classification-based prognostic scoring system (WPSS) was also divided into two groups: very low/low/Int and high/very high, and WPSS was able to predict the outcome of del(5q) patients more clearly than IPSS.Together with additional cytogenetic data, WPSS might be useful for clinical decision making in MDS patients with del(5q).

show abstract

Section: Discussionmentioning

confidence: 99%

Myelodysplastic syndrome with chromosome 5 abnormalities: a nationwide survey in Japan

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Chromosomal abnormalities and the resultant unique molecular rearrangements may provide insights into the pathogenesis of each disease. The presence of geographic heterogeneity of cytogenetic abnormalities in hematological malignancies has been described, [14][15][16] and a better understanding of the genetic and environmental factors could reveal etiological factors involved in the development of leukemia. However, cytogenetic data of AML patients are lacking from many parts of the world.…”

Section: Discussionmentioning

confidence: 99%

Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China

Cheng

Wang

et al. 2009

Leukemia

Self Cite

View full text Add to dashboard Cite

Geographic heterogeneity of cytogenetic patterns in hematological malignancies has been reported earlier, but few systematic studies of cytogenetic abnormalities in acute myeloid leukemia (AML) patients are available. We examined the karyotypic patterns in 1432 de novo AML patients from a single center in China and compared our data with reports from other regions of the world. Chromosomal abnormalities were detected in 746 (58%) cases. The most frequent cytogenetic abnormality was t(15;17), detected in 14% of successful cases, followed by t(8;21) in 8%, and t(9;22), þ 21 and þ 8 each in 2%. The mean age of patients with a translocation karyotype was significantly younger than that of patients with normal, deletion or trisomy karyotypes. A higher incidence of AML M3 and a lower frequency of M4 were observed in the Asian population and the frequencies of certain cytogenetic aberrations were different from those in the earlier reports. Population-based age-specific incidences of AML were calculated and compared with those in western reports.

show abstract

“…This was lower than presenting age in Western reports of 76 years in United States (Ma et al,2007), 73 years in Dusseldorf, Germany (Neukirchen et al, 2011) (Sole et al, 2005). In Asia MDS has been reported to occur more frequently in younger individuals (Japan (57 years), Korea (53 years) and China (59 years) (Lee et al,1999;Chen B et al, 2005;Matsuda et al, 2005). The reason for the high incidence in younger individuals is still unclear, and the differences in disease features between young and elderly patients with MDS have been not well recognized.…”

Section: Dear Editormentioning

confidence: 99%

Does Indian Myelodysplastic Syndrome have a Biology Different from that in the West ?

Chaubey

Sazawal²,

Mahapatra³

et al. 2016

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries

Cited by 105 publications

References 21 publications

Myelodysplastic syndrome with chromosome 5 abnormalities: a nationwide survey in Japan

Myelodysplastic syndrome with chromosome 5 abnormalities: a nationwide survey in Japan

Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China

Does Indian Myelodysplastic Syndrome have a Biology Different from that in the West ?

Contact Info

Product

Resources

About