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This article continues the dialogue about the proper breadth of the marketing curriculum. Specifically, we suggest that developing better links between marketing and other areas of business and fostering connections between marketing and liberal arts courses provide benefits to students, organizations, and society. Suggestions are made regarding pedagogy and necessary changes in the academic reward structure.

Key Clinical MessageCongenital factor VII deficiency (FVIID) is a rare disorder with a wide range of bleeding manifestations. The disorder does not protect patients against occurrence of thrombosis, and deep vein thrombosis can occur in the setting of surgery and recombinant factor VIIa replacement.

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Genetic algorithms (GA) are artificial intelligence techniques based on the theory of evolution that through the process of natural selection evolve formulae to solve problems or develop control strategies. We designed a GA to examine relationships between stream physical characteristics and trout distribution data for 3rd-, 5th-, and 7th-order stream sites in the Cascade Mountains, Oregon. Although traditional multivariate statistical techniques can perform this particular task, GAs are not constrained by assumptions of independence and linearity and therefore provide a useful alternative. To help gauge the effectiveness of the GA, we compared GA results with results from proportional trout distributions and multiple linear regression equations. The GA was a more effective predictor of trout distributions (paired t test, P < 0.05) than other methods and also provided new insights into relationships between stream geomorphology and trout distributions. Most importantly, GA equations emphasized the nonindependence of stream channel units by revealing that (i) the factors that influence trout distributions change along a downstream continuum, and (ii) channel unit sequence can be critical. Superior performance of the GA, along with the new information it provided, indicates that genetic algorithms may provide a useful alternative or supportive method to statistical techniques.

Granulomas in the bone marrow are usually caused by infectious or hematological diseases, and drugs are only rarely implicated as causative agents. Recent reports have drawn attention to the role of amiodarone in the etiology of bone marrow granulomas. We report two cases of amiodarone-induced bone marrow granulomas in patients being investigated for refractory anemia and pancytopenia, respectively. Since both patients had life-threatening arrhythmias, discontinuation of the drug followed by rechallenge was not possible. Both patients did well in spite of continued amiodarone therapy, indicating that the underlying hematological illnesses were unrelated to the granulomas. Amiodarone should be considered as a possible cause of bone marrow granulomas after the exclusion of other causes. Continued use of amiodarone after granuloma formation must be dictated by the underlying cardiac condition.

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