Chromosomal Location of Three Unconventional Myosin Heavy Chain Genes in the Mouse

Whitmer, Jeffrey D.; Koslovsky, Janet; Bähler, Martin; Mercer, John A.

doi:10.1006/geno.1996.0622

Cited by 3 publications

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“…All of the TLRs (of which 10 are recognized in humans) have a conserved TIR motif in the cytoplasmic domain and, as far as is known, require MyD88 (a cytoplasmic TIR-bearing protein) for signal transduction, at least in some measure [40,41,42]. …”

Section: The Principal Receptors That Engender a Local Or Systemic Inmentioning

confidence: 99%

“…The TLRs are single spanning transmembrane proteins that are coupled to a wide array of signaling molecules within the cell. All of the TLRs (of which 10 are recognized in humans) have a conserved TIR motif in the cytoplasmic domain and, as far as is known, require MyD88 (a cytoplasmic TIR-bearing protein) for signal transduction, at least in some measure [ 40 , 41 , 42 ].…”

Section: The Principal Receptors That Engender a Local Or Systemic Inflammatory Responsementioning

confidence: 99%

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Beutler

2002

Crit Care

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A pure reductionist approach can sometimes be used to solve an exceptionally complicated biologic problem, and sepsis is nothing if not complicated. A serious infection promptly leads to changes in many aspects of host physiology, including alterations in circulation, metabolism, renal, hepatic, and neuroendocrine function; all of these changes happen at once, and each influences one another. It is difficult to tease apart a problem of this sort, if only because the systems affected are so profoundly interactive. The key to understanding sepsis, insofar as we do understand it at present, was found in the use of genetic tools to study the very earliest events that take place at the interface of the pathogen and the host. The continued application of both forward and reverse genetic methods, in both mammals and insects, is steadily revealing the central biochemical events that occur during infection.

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Section: The Principal Receptors That Engender a Local Or Systemic Inmentioning

confidence: 99%

Section: The Principal Receptors That Engender a Local Or Systemic Inflammatory Responsementioning

confidence: 99%

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Beutler

2002

Crit Care

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Physical Mapping of Human Myosin-IXB (MYO9B), the Human Orthologue of the Rat Myosin myr 5, to Chromosome 19p13.1

et al. 1997

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Role of the cofilin 2 gene in regulating the myosin heavy chain genes in mouse myoblast C2C12 cells

et al. 2017

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The cofilin 2 (CFL2) and myosin heavy chain (MyHC) genes play a key role in muscle development and myofibrillar formation. The aim of the present study was to investigate the effect of CFL2 on genes involved in fiber formation and the mechanisms underlying this process. Undifferentiated and differentiated C2C12 cells (UDT and DT, respectively) were transfected with CFL2 small interfering RNA (siRNA). CFL2 mRNA and protein levels were assessed using reverse transcription polymerase chain reaction (RT-PCR) and western blotting, respectively. MyHC gene expression in UDT and signaling pathway-related factors were observed with quantitative PCR (RT‑qPCR) and western blotting. Fluorescence microscopy was used to analyze the cytoskeletal effects of CFL2. The mRNA and protein expressions of CFL2, four MyHC isoforms (MyHC-I, MyHC-IIa, MyHC-IIb and MyHC-IIx), p38 mitogen-activated protein kinase, cAMP-response element-binding protein, AMP-activated protein kinase α1, and myocyte enhancer factor 2C, were significantly decreased in UDT. However, extracellular signal-regulated kinase 2 expression was significantly increased. Slightly decreased CFL2 protein and mRNA expression was observed in DT C2C12 cells transfected with CFL2 siRNA. Fluorescence microscopy revealed a significant decrease of CFL2 in the cytoplasm, but not the nucleus, of UDT, compared with normal cells. These results indicated that the mouse CFL2 gene may be involved in the regulation of MyHC via the key signaling molecules of CFL2-related signaling pathways.

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Chromosomal Location of Three Unconventional Myosin Heavy Chain Genes in the Mouse

Cited by 3 publications

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Physical Mapping of Human Myosin-IXB (MYO9B), the Human Orthologue of the Rat Myosin myr 5, to Chromosome 19p13.1

Role of the cofilin 2 gene in regulating the myosin heavy chain genes in mouse myoblast C2C12 cells

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