Physical Mapping of Human Myosin-IXB (MYO9B), the Human Orthologue of the Rat Myosin myr 5, to Chromosome 19p13.1

Bähler, Martin; Kehrer, Iris; Gordon, Laurie; Stöffler, Hanns-Eugen; Olsen, Anne S.

doi:10.1006/geno.1997.4776

Cited by 10 publications

(6 citation statements)

References 13 publications

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“…The rat ortholog of MyoIXB, myr 5, has been shown to play an important role in actin remodeling during bacterial invasion of epithelial cells. 34,55 This suggests the possibility that MYO9B functional variants may alter bacterial handling at the colonic epithelial barrier, perhaps resulting in altered mucosal response to commensal bacteria.…”

Section: Discussionmentioning

confidence: 97%

Association between genetic variants in myosin IXB and Crohnʼs disease

Cooney

Cummings

Pathan

et al. 2009

Inflammatory Bowel Diseases

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Section: Discussionmentioning

confidence: 97%

Association between genetic variants in myosin IXB and Crohnʼs disease

Cooney

Cummings

Pathan

et al. 2009

Inflammatory Bowel Diseases

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“…These data confirm that CD should always be considered in the clinical evaluation of TS patients throughout their lives, though this does not necessarily happen. The analysis of the MYO9B myosin IXB ( MYO9B ) gene, which is associated with susceptibility to CD (Bähler, Kehrer, Gordon, Stoffler, & Olsen, ), would be an interesting approach to identifying an at‐risk group among TS patients. MYO9B encodes a Ras homologous (Rho) family guanosine‐tri‐phosphatase (GTPase)‐activating protein that is involved in epithelial cell cytoskeletal organization and influences tight junction assembly (Matter & Balda, ; Post et al., ).…”

Section: Discussionmentioning

confidence: 99%

Analysis of PTPN22, ZFAT and MYO9B polymorphisms in Turner Syndrome and risk of autoimmune disease

Villanueva-Ortega

Ahedo

Fonseca-Sánchez

et al. 2017

Int J Immunogenetics

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Turner syndrome (TS) is one of the most common sexual chromosome abnormalities and is clearly associated with an increased risk of autoimmune diseases, particularly thyroid disease and coeliac disease (CD). Single-nucleotide polymorphism analyses have been shown to provide correlative evidence that specific genes are associated with autoimmune disease. Our aim was to study the functional polymorphic variants of PTPN22 and ZFAT in relation to thyroid disease and those of MYO9B in relation to CD. A cross-sectional comparative analysis was performed on Mexican mestizo patients with TS and age-matched healthy females. Our data showed that PTPN22 C1858T (considered a risk variant) is not associated with TS (X = 3.50, p = .61, and OR = 0.33 [95% CI = 0.10-1.10]). Also, ZFAT was not associated with TS (X = 1.2, p = .28, and OR = 1.22 [95% CI = 0.84-1.79]). However, for the first time, rs2305767 MYO9B was revealed to have a strong association with TS (X = 58.6, p = .0001, and OR = 10.44 [95% C = 5.51-19.80]), supporting a high level of predisposition to CD among TS patients. This report addresses additional data regarding the polymorphic variants associated with autoimmune disease, one of the most common complications in TS.

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“…Although it was previously proposed that Rent1 was located at 19p13.11-p13.2 (Perlick et al, 1996; full data not shown), we have found the human gene on two cosmid sequences from 19p12 (AC003972 and AC004517), again suggesting synteny with the mouse. Like Rent1, Myo9b was determined to be at 19p13.1 (Bahler et al, 1997). Because this gene is not on any sequenced human genomic cosmid clone, there are no conflicting data with the 19p13.1 mapping.…”

Section: Discussionmentioning

confidence: 99%