Chromosomal breaks and sister chromatid exchanges (SCE) in patients with herpetic stomatitis

Abstract

Zervou-Valvi F, Biizopoulou-Kyrkanidou E, Angelopoulos AP. Chromosomal breaks and sister chtomatid exchanges (SCE) in patients with herpetie stomatitis. .) Oral Pathol 1986: 15: LS 1-154.Chromosomal breakage and sister-chroniatid exchanges (SCE) were studied in peripheral lymphocytes of 9 patients with primary herpetie stomatitis (PHS). 12 patients with secondary herpetie stomatitis (SnS) and 12 controls. The incidence of chromosomal breakage was signifieantly higher in PHS patients (mean 23%, P.=().0()()2) and in SHS patients (mean 20.25%, P. = 0.0003) compared to the controls (mean 4.2%). The incidence of SCE per 46 chromosomes was significantly higher in SHS patients (mean 16.564) compared with (P.<O.()()1) the eontrols (mean 11.367) and compared with (P.=0.006) the PHS patients (mean 12.131). It is concluded that both PHS and SHS patients exhibit structural chromosomal damage; SHS patients in addition exhibit more repaired ehromosomal lesions.

Frequency of sister chromatid exchanges in the lymphocytes of patients with atopic dermatitis

“…It has been shown that viruses can cause visible damage to chromosomes of mammalian cells. Increased SCE scores have been found in patients with secondary herpetic stomatitis and with herpetic lesions 35 . Elevated frequencies of SCE have also been reported in peripheral blood lymphocytes of patients with Behcet's disease (BD), 36 ankylosing spondylitis 37 and ataxia telangiectasia 38 .…”

Sister chromatid exchange (SCE) analysis in periodontitis

“…2000). It has been shown that viruses can cause visible damage to chromosomes of mammalian cells (Zervou‐Valvi et al. 1986).…”

“…1986). Elevated SCE scores were found in patients with secondary herpetic stomatitis and with herpetic lesions (Zervou‐Valvi et al. 1986).…”

“…Viruses have been shown to cause visible damage to chromosomes of mammalian cells. Elevated SCE frequency was found in some chronic, viral and bacterial infections (Zervou‐Valvi et al. 1986, Cottliar et al.…”

“…Viruses have been shown to cause visible damage to chromosomes of mammalian cells. Elevated SCE frequency was found in some chronic, viral and bacterial infections (Zervou-Valvi et al 1986, Cottliar et al 2000. Periodontal diseases are bacterial infections and genetic factors influence susceptibility to the different forms of periodontal disease (Michalowicz 1994).…”