Chromium (III) and chromium (VI) as important players in the induction of genotoxicity – current view

Sawicka, Ewa; Jurkowska, Karolina; Piwowar, Agnieszka

doi:10.26444/aaem/118228

Cited by 27 publications

(32 citation statements)

References 69 publications

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“…Cr (III) can cause genetic effects when specifically confronted with purified nucleic or subcellular targets, however, when Cr (III) compound was tested in cellular system, this potential genotoxic capacity was lost (Sawicka et al, 2020; Silvio et al, 1989). Cr (VI) intracellularly reduces into Cr (III) with the latter forming potentially genotoxic complexes with DNA (Jomova and Valko, 2011; O’Flaherty et al, 2001).…”

Section: Resultsmentioning

confidence: 99%

Cr (III) genotoxicity and oxidative stress: An occupational health risk for leather tannery workers of South Asian developing countries

2022

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In the leather industry, Cr (III) is used as a basic tanning agent. The wastewater discharged from the tannery industry contains a high concentration of chromium. Recent studies indicate the genotoxic effects especially DNA damage and oxidative stress of Cr (III) in tannery workers. Cr (III) interacts with DNA to form DNA cross-links and DNA strand breaks. It also modifies the oxidative DNA base through the Haber–Weiss reaction. The present study is based on an overview of scientific literature and previous observations regarding the effects of tannery chromium effluents on exposed workers and the population in the vicinity. This study strongly suggests for use of a non-toxic substitute of chromium to be used for the tanning process and placement of tannery industries on the outskirts of the city. In South Asian developing countries like India, Pakistan and Bangladesh where the economy is strongly dependent on leather manufacturing industries, there is a need to spread proper information regarding the harmful effects of chromium toxicity to the workforce employed in the tannery and also to the people living in the surrounding area. Workers should be provided with the required safety protections like gloves, aprons, foot/shoe covers, masks, etc. Last but most important on an immediate basis is the installation of the proper efficient waste treatment plant, so that, waste should be treated before moving out of the industry.

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Section: Resultsmentioning

confidence: 99%

Cr (III) genotoxicity and oxidative stress: An occupational health risk for leather tannery workers of South Asian developing countries

2022

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“…Cr(VI) does not directly interact with DNA, but the genotoxicity of Cr(VI) is rather attributed to its intracellular reduction to Cr(III) via reactive intermediates. The products from the reaction such as ROS, Cr (V), and Cr (IV) are potential sources of oxidative damage induced by Cr(VI) which can lead to two types of DNA damage namely, oxidative damage and Cr(III)-DNA interactions which proceeded via a three-step cross-linking mechanism, i.e., reduction of Cr(VI) to Cr(III), binding of Cr(III) to DNA binding, and protein capture by DNA-bound Cr(III) generating protein-Cr(III)-DNA cross-links [16,17].…”

Section: Cytotoxicity and Genotoxicity Of Crmentioning

confidence: 99%

Bacterial Reduction of Cr(VI): Operational Challenges and Feasibility

et al. 2021

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Purpose of Review Hexavalent chromium, Cr(VI), and trivalent chromium, Cr(III), are two chromium compounds with practical importance due to their high occurrence and solubility in the environment. Current Cr(VI) treatment techniques involve chemical reduction of Cr(VI) to Cr(III), which posed serious threat to workers and environment notably from long exposure and toxic fumes.Recent Findings Numerous reports have demonstrated the feasibility of using biological processes for the treatment of Cr(VI) industrial effluents by either pure culture or a consortium of Cr(VI)-reducing bacteria, with various degrees of success. Among issues to be considered include high cost of nutrient for the bacteria, low Cr resistant-reducing ability of environmental isolates, difficulty in scaling up finding in the laboratory to pilot scale and on-site application as well as the understanding on the dynamic underlying mechanisms for bacterial Cr(VI) reduction. Summary This review highlights cytotoxicity and genotoxicity properties of Cr(VI), which form the biggest motivation for continuous development in the field of Cr(VI) treatment technologies, latest finding in aerobic and anaerobic bacterial reduction of Cr(VI), operational challenges for bacterial Cr(VI) reduction, and some examples for laboratory-scale and pilot-scale evaluation of free and immobilized (biofilm) cells of Cr(VI) resistant-reducing bacteria.

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“…Chromium is commonly used for the production of steel and other alloys, bricks, dyes and pigments, leather tanning, electroplating and wood preserving [1]. It was reported that occupational exposure to trivalent chromium can lead to oxidative stress and DNA damage in tannery workers [2]. Due to extensive use in industrial processes, large quantities of Cr compounds are discharged into the environment and contaminate the air, soil, surface water and groundwater.…”

Section: Introductionmentioning

confidence: 99%

Development of Solid Phase Extraction Method Based on Ion Imprinted Polymer for Determination of Cr(III) Ions by ETAAS in Waters

Trzonkowska

Leśniewska

Godlewska‐Żyłkiewicz

2022

Water

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In this work, a new solid phase extraction method for the determination of chromium species in water samples by electrothermal atomic absorption spectrometry was developed. For selective separation of Cr(III) ions under dynamic conditions, two ion imprinted polymers containing Cr(III)-1,10-phenanthroline complex (Cr(III)-phen) were prepared with the use of one (styrene, ST) or two (styrene and 4-vinylpyridine, ST-4VP) functional monomers. The physicochemical properties of those solid sorbents towards Cr(III) ions were studied and compared. It was found that Cr(III) ions were retained on the Cr(III)-phen-ST and Cr(III)-phen-ST-4VP polymers with high efficiency and repeatability (91.6% and 92.9%, RSD < 2%) from solutions at pH 4.5. The quantitative recovery of the analyte (91.7% and 93.9%, RSD < 4%) was obtained with 0.1 mol/L EDTA solution. The introduction of 4VP, an additional functional monomer, improved selectivity of the Cr(III)-phen-ST-4VP polymer towards Cr(III) ions in the presence of Cu(II), Mn(II) and Fe(III) ions, and slightly decreased the sorption capacity and stability of that polymer. The accuracy of procedures based on both polymeric sorbents was proved by analyzing the standard reference material of surface water SRM 1643e. The method using the Cr(III)-phen-ST polymer was applied for determining of Cr(III) ions in tap water and infusion of a green tea.

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Chromium (III) and chromium (VI) as important players in the induction of genotoxicity – current view

Abstract: Sawicka E, Jurkowska K, Piwowar A. Chromium (III) and chromium (VI) as important players in the induction of genotoxicity-current view. Ann Agric Environ Med.

Cited by 27 publications

References 69 publications

Cr (III) genotoxicity and oxidative stress: An occupational health risk for leather tannery workers of South Asian developing countries

Cr (III) genotoxicity and oxidative stress: An occupational health risk for leather tannery workers of South Asian developing countries

Bacterial Reduction of Cr(VI): Operational Challenges and Feasibility

Development of Solid Phase Extraction Method Based on Ion Imprinted Polymer for Determination of Cr(III) Ions by ETAAS in Waters

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