Chromatographic fingerprinting and free-radical scavenging activity of ethanol extracts of Muntingia calabura L. leaves and stems

Buhian, William Patrick Cruiz; Rubio, R; Martin-Puzon, Juliana Janet R.

doi:10.1016/j.apjtb.2016.11.016

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…Muntingia calabura L. is a fruit grown in Southeast Asia and Central and South America (Buhian, Rubio, & Martin-Puzon, 2017). Known popularly as both calabura or cherry jamaica, the plant belongs to the family Elaeocarpaceae, the only species in the genus Muntingiacea (Gomathi, Anusuya, & Manian, 2013).…”

Section: Introductionmentioning

confidence: 99%

Mathematical modeling and effect of thin-layer drying and lyophilization on antioxidant compounds from ultrasonic-assisted extracted Muntingia calabura peels

et al. 2021

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Muntingia calabura fruits are rich in bioactive compounds such as antioxidants, and the consumption of these compounds is associated with cancer prevention and aging. In this study, mathematical models were used to fit the experimental data of the Muntingia calabura peel drying kinetics, and the effective diffusion coefficient, activation energy and thermodynamic properties of the process were determined. Then, the effect of the drying temperature on the antioxidant activity and phenolic compounds of fruit peels was examined using conventional extraction and ultrasonication. Among the analyzed models, the logarithmic model was selected to represent the drying phenomenon of the calabura peel kinetics. The effective diffusion coefficient decreased by 74% as the temperature increased from 40 to 60°C, and the activation energy for liquid diffusion during drying was 23.96 kJ mol-1. The enthalpy and entropy decreased with increasing temperature, while the Gibbs free energy increased by 5% for each 10°C increase in temperature. Regarding the content of phenolic compounds and the antioxidant activity of the calabura peel, it was observed that an increase in the drying temperature had a positive effect on the conservation of the bioactive compounds, making it possible to conclude that drying at 60°C and ultrasound extraction are the most suitable approach to conduct the process.

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Section: Introductionmentioning

confidence: 99%

Mathematical modeling and effect of thin-layer drying and lyophilization on antioxidant compounds from ultrasonic-assisted extracted Muntingia calabura peels

et al. 2021

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“…Oleh karena itu, tanaman yang mengandung flavonoid banyak dimanfaatkan sebagai bahan obat herbal. Selain itu, beberapa penelitian telah melaporkan efek farmakologi dari M. calabura sebagai antioksidan (Buhian et al, 2017;Balan et al, 2015;Zakaria et al, 2014a;Sindhe et al, 2013;Gomathi et al, 2013;Preethi et al, 2012;Zakaria et al, 2011;Siddiqua et al, 2010;Preethi et al, 2010); anti-inflamasi (Balan et al, 2015;Zakaria et al, 2014a;Gomathi et al, 2013;Preethi et al, 2012;Zakaria et al, 2007a); antimikroba (Buhian et al, 2016;Rajesh et al, 2014;Sufian et al, 2013;Sibi et al, 2013;Sibi et al, 2012); antidiabetes (Khan et al, 2015;Sindhe et al, 2013;Sridhar et al, 2011); antikanker (Rofiee et al, 2015;Sufian et al, 2013;Chen et al, 2004;Chen et al, 2005;Kaneda et al, 1991); antinyeri (Zakaria et al, 2016;Zakaria et al, 2014b;Yusof et al, 2013;Sani et al, 2012;Zakaria et al, 2007b); antiulcer (Balan et al, 2015;Ibrahim et al, 2012) dan lainlain. Berdasarkan bioaktivitas M. calabura dari tinjauan tersebut, review ini bertujuan untuk memberikan fakta ilmiah terkait sinergitas senyawa metabolit sekunder dan aktivitas biologis dari M. calabura sebagai bahan acuan pada penelitian selanjutnya.…”

Section: Pendahuluanunclassified

“…Sehingga, antioksidan diperlukan sebagai penangkal radikal bebas. Antioksidan merupakan konstituen kimia yang mampu menangkal radikal bebas dengan mendonorkan protonnya (Fitriana et al, 2016 calabura (EDMC) yaitu ekstrak metanol (EMDMC) (Balan et al, 2015;Zakaria et al, 2014a;Zakaria et al, 2011;Siddiqua et al, 2010), ekstrak etanol (EEDMC) (Buhian et al, 2017), ekstrak petroleum eter (EPEDMC) (Sindhe et al, 2013), ekstrak kloroform (EKDMC) (Sindhe et al, 2013;Zakaria et al, 2011), ekstrak etil asetat (EEADMC) (Sindhe et al, 2013) dan ekstrak aquades (EAQDMC) (Sindhe et al, 2013;Zakaria et al, 2011 (Preethi et al, 2010), ekstrak kloroform (Vijayanand and Thomas, 2016;Preethi et al, 2010), ekstrak etil asetat (EEABMC), ekstrak butanol (EBBMC) (Preethi et al, 2010), ekstrak etanol (EEBMC) (Vijayanand and Thomas, 2016), ekstrak metanol (EMBMC) (Vijayanand and Thomas, 2016;Preethi et al, 2012;Preethi et al, 2010), ekstrak aquades (EAQBMC) (Vijayanand and Thomas, 2016) dan ekstrak campuran metanol:aseton:air…”

Section: Antioksidanunclassified

“…(3:5:3) (Gomathi et al, 2013). Hasil uji menunjukkan bahwa EMBMC memberikan hasil penghambatan DPPH (94% pada konsentrasi 500 μg/mL) (Preethi et al, 2012) dan total fenolat sejumlah 1486 mg/100 g (Preethi et al, 2010 480,6 ± 0,02 g/mL, pada EEABMC juga menunjukkan aktivitas penghambatan radikal nitrit oksida yang baik sebesar 497,2 ± 0,08 g/mL (Preethi et al, 2010) dan pada EEBMC dilakukan uji penghambatan CUPRAC dengan nilai penghambatan moderat sebesar 55,6 ± 0,00% (Vijayanand and Thomas, 2016 (93,9 ± 2,2%) pada konsentrasi 4 mg/mL (Buhian et al, 2017) dan EAQAMC dengan nilai penghambatan 61% dibandingkan dengan kontrol positif asam askorbat (58%) dalam konsentrasi masing-masing 400 μM (Khan et al, 2015).…”

Section: Antioksidanunclassified

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Metabolit sekunder dari Muntingia calabura dan bioaktivitasnya

Putri

Fatmawati

2019

ALCHEMY J.Pen.Kim

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Muntingia calabura (Muntingiaceae) merupakan Jamaican cherry yang dikenal di Indonesia sebagai Kersen atau Talok. Metabolit sekunder sebagai konstituen kimia telah diisolasi dari daun, batang dan akar M. calabura. Flavonoid merupakan konstituen utama penyusun metabolit sekunder dari tanaman ini. Kelompok flavonoid telah dilaporkan memiliki efek farmakologi yang baik. Beberapa literatur melaporkan bioaktivitas M. calabura sebagai antioksidan, antidiabetes, antimikroba, antikanker, anti-inflamasi dan lain-lain. Review ini bertujuan memberikan fakta ilmiah terkait sinergitas metabolit sekunder dan bioaktivitas M. calabura yang diperlukan untuk penelitian kimia bahan alam lebih lanjut.The secondary metabolites of Muntingia calabura and its bioactivity. Muntingia calabura (Mutingiaceae) was recognized as Jamaican cherry called as Kersen or Talok in Indonesia. The chemical constituents have been isolated from leave, stem and root of M. calabura. The main chemical constituent of the secondary metabolite is flavonoid. The flavonoid group has been reported as a good source in pharmacological aspect. Most of literatures reported that M. calabura has a good bioactivity as an antioxidant, antidiabetic, antimicrobial, anticancer, anti-inflammatory and others. This review aims to provide the scientific evidences related to the synergism of secondary metabolites and the bioactivities of M. calabura for further research on natural products.

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Muntingia calabura: Chemical Composition, Bioactive Component and Traditional Uses

Mastuki

Faudzi

Ismail

2019

Wild Fruits: Composition, Nutritional Value and Products

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Muntingia calabura, commonly known as Jamaican cherry, is a plant species belonging to the family Muntingiaceae with variety of traditional uses. Following on these folklore claims, the works on phytochemicals constituents, traditional uses, pharmacological benefits and their mechanisms are presented in a number of studies as well as the in vitro and in vivo investigations. This species contains valuable phytochemicals with known medicinal properties that are beneficial to the well-being (e.g. anti-microbial, anti-nociceptive, antiinflammatory etc.). Still, further and in-depth researches including a well-designed pharmacological tests and randomized clinical trials are required to unlock the hidden potential medicinal values of this plant, thus lead to the new drug discoveries of M. calabura.

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Chromatographic fingerprinting and free-radical scavenging activity of ethanol extracts of Muntingia calabura L. leaves and stems

Cited by 8 publications

References 28 publications

Mathematical modeling and effect of thin-layer drying and lyophilization on antioxidant compounds from ultrasonic-assisted extracted Muntingia calabura peels

Mathematical modeling and effect of thin-layer drying and lyophilization on antioxidant compounds from ultrasonic-assisted extracted Muntingia calabura peels

Metabolit sekunder dari Muntingia calabura dan bioaktivitasnya

Muntingia calabura: Chemical Composition, Bioactive Component and Traditional Uses

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