Muntingia calabura: Chemical Composition, Bioactive Component and Traditional Uses

Mastuki, Siti Nurulhuda; Faudzi, Siti Munirah Mohd; Ismail, Norsharina

doi:10.1007/978-3-030-31885-7_41

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…Saponins can interact with many membrane lipids, such as phospholipids, precursors of prostaglandins, and other inflammatory mediators [13]. The mechanism of alkaloids in the inflammatory process is by suppressing the release of histamine by mast cells and reducing the secretion of IL-1 by monocytes and PAF (platelet activating factors) on platelets [14].…”

Section: Benefits Of Cherry Leaf Extract On Wound Healing E Reducing ...mentioning

confidence: 99%

Literature Review: Effect of Cherry Leaf Extract on Diabetic Wounds

Anita¹

2023

Advances in Health Sciences Research

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The prevalence of diabetes mellitus (DM) is increasing from year to year. One threat must be watched out for if a DM patient is injured. These wounds can become chronic diabetic wounds where the injury is easily infected or infected with pathogenic bacteria. Since chronic diabetic wounds usually occur on the feet, the most severe risk of this condition is the amputation of the leg. Wound healing can be done by adding traditional ingredients as an alternative treatment, such as cherry leaves. Cherry leaf can potentially be used in wound care because it functions as an antiseptic, anti-inflammatory, and analgesic. The purpose of this study was to examine the effectiveness of cherry leaf in diabetic wound healing. The research method is a literature study. This study uses a literature review method with keywords like Muntingia calabura leaves, wound, and diabetic mice. The databases used are Google Scholar, Pubmed, and Science Direct. The results of the search obtained three research articles. The article used is true-experiment research with animal models using mice as experimental animals. Data analysis uses literature selection (PRISMA) with inclusion criteria: manuscripts that can be accessed in full text in the range of years published from 2015-2022. The feasibility quality assessment uses the JBI Critical appraisal case-control study. The results showed an effect of giving cherry leaf extract on diabetic wound healing. The conclusion is that cherry leaf extract has active compounds that are important in the wound healing process, both acute wounds and chronic wounds, such as diabetic ulcers.

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Section: Benefits Of Cherry Leaf Extract On Wound Healing E Reducing ...mentioning

confidence: 99%

Literature Review: Effect of Cherry Leaf Extract on Diabetic Wounds

Anita¹

2023

Advances in Health Sciences Research

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“…Muntingia calabura L. (MC), commonly known as “ ceri hutan ” in Malaysia, belongs to the Muntingiaceae family. The plant has been used traditionally to treat gastric ulcer, prostate gland swelling, cold and headache, as well as to lower blood glucose level via decoction or poultice 6 . Positive pharmacological properties of MC were reported in various studies, including inhibition of gastric damages 7 , protection against bacterial infections 8 and anti-inflammatory activity against induced paw edema 9 .…”

Section: Introductionmentioning

confidence: 99%

Metabolic Alterations in Streptozotocin–nicotinamide-induced Diabetic Rats Treated with Muntingia calabura Extract via 1H-NMR-based Metabolomics

et al. 2023

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Diabetes mellitus (DM) is a metabolic endocrine disorder caused by decreased insulin concentration or poor insulin response. Muntingia calabura (MC) has been used traditionally to reduce blood glucose levels. This study aimed to support the traditional claim of MC as a functional food and blood-glucose-lowering regimen. The antidiabetic potential of MC has been tested on a streptozotocin–nicotinamide (STZ-NA) induced diabetic rat model by using the 1H-NMR-based metabolomic approach. Serum biochemical analyses revealed that treatment with 250 mg/kg body weight (bw) standardized freeze dried (FD) 50% ethanolic MC extract (MCE 250) showed favorable serum creatinine (37.77 ± 3.53 µM), urea (5.98 ± 0.84 mM) and glucose (7.36 ± 0.57 mM) lowering capacity, which was comparable to the standard drug, metformin. The clear separation between diabetic control (DC) and normal group in principal component analysis indicated the successful induction of diabetes in the STZ-NA-induced type 2 diabetic rat model. A total of nine biomarkers, including allantoin, glucose, methylnicotinamide, lactate, hippurate, creatine, dimethylamine, citrate and pyruvate were identified in rats’ urinary profile discriminating DC and normal groups through orthogonal partial least squares-discriminant analysis. Induction of diabetes by STZ-NA was due to alteration in the tricarboxylic acid (TCA) cycle, gluconeogenesis pathway, pyruvate metabolism and nicotinate and nicotinamide metabolism. Oral treatment with MCE 250 in STZ-NA induced diabetic rats showed improvement in the altered carbohydrate metabolism, cofactor and vitamin metabolic pathway, as well as purine and homocysteine metabolism.

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“…The results of the phytochemical analysis of this fruit contain saponins, flavonoids, tannins, and steroids. In addition, M. calabura fruit is known to be enriched with phenolic compounds related to its antioxidant capacity, including gallocatechin, epigallocatechin, catechins, flavanols, naringenin, quercetin, gallic acid, vanillic acid, chlorogenic acid, caffeic acid, ρ-coumaric acid, ferulic acid, Ɛ-hydroxycinnamic acid and myricetin (Mastuki et al, 2019). The results of research that has been conducted with fresh ripe M. calabura fruit showed an IC50 value of 41.10 µg/mL classified as a very strong antioxidant category.…”

Section: Introductionmentioning

confidence: 99%

In vitro anti-aging activity of Muntingia calabura L. fruit extract and its fractions

Nur¹,

Angelina²,

Aswad³

et al. 2021

J Pharm Pharmacogn Res

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Context: Premature aging usually occurred due to free radicals reducing the skins’ physiological functions. Muntingia calabura, a plant containing rich antioxidants, has the potential to overcome this problem. Aims: To evaluate the antioxidant capacity of M. calabura in inhibiting the premature aging process, to be potentially developed into an antiaging active ingredient. Methods: The samples were extracted using ethanol 96%, and processed into n-hexane, ethyl acetate, and ethanol fractions, respectively. Total phenolic content was determined, followed by the evaluation of antioxidant capacity through DPPH, FRAP, and ABTS assay. Further, anti-elastase was conducted using human neutrophil elastase as a skin degradation enzyme, followed by an anti-collagenase test. Finally, normal cell proliferation was also evaluated via the MTT method measuring cell viability on HDFa cells. Results: As the results, ethanol extract, ethyl acetate fraction, and ethanol fraction showed a strong antioxidant effect, having great capacity reducing DPPH, ABTS radicals, and also iron reduction, in contrast to n-hexane fraction that exhibited only weak activity. The antioxidant trend capacities were found directly correlated to total phenolic contents. Furthermore, the ethyl acetate fraction was found to have optimum activity in inhibiting elastase and collagenase enzymes, showing a similar impact on cell viability. Conclusions: The ethyl acetate fraction from M. calabura exhibits the prospect for further development to support its effectiveness as an active ingredient in antiaging cosmetics.

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Muntingia calabura: Chemical Composition, Bioactive Component and Traditional Uses

Cited by 5 publications

References 34 publications

Literature Review: Effect of Cherry Leaf Extract on Diabetic Wounds

Literature Review: Effect of Cherry Leaf Extract on Diabetic Wounds

Metabolic Alterations in Streptozotocin–nicotinamide-induced Diabetic Rats Treated with Muntingia calabura Extract via 1H-NMR-based Metabolomics

In vitro anti-aging activity of Muntingia calabura L. fruit extract and its fractions

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