Chromatographic behaviour of some platinum(II) complexes on octadecylsilica dynamically modified with a mixture of a cationic and an anionic amphiphilic modifier

Macka, Mirek; Borák, J.

doi:10.1016/0021-9673(93)83464-4

Cited by 17 publications

(7 citation statements)

References 23 publications

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“…9/10, May 1999 accordance with that of the comments of Macka and Borak [22]. With this composition of the modifiers the efficiency of the TBAHSO 4 in the running buffer was increased, so the system became moderately anion-exchanger.…”

Section: Discussionmentioning

confidence: 99%

“…Macka and co-workers [21,22] managed to separate different kinds of platinum species by using anion and cation exchangers together in the running buffer. The disadvantage of this method is the use of an ionic gradient and a heated column.…”

Section: Cl\ /Nh 3 Ci\ /Nh a /Pt\ Nh:~pt\ci/ Nh 3 CL Ci/pt\cimentioning

confidence: 99%

“…The disadvantage of this method is the use of an ionic gradient and a heated column. In this paper we describe an alternate selective, simple and rapid method to quantify the species by modification of the HPLC system of Macka and co-workers [22]. In this paper we describe an alternate selective, simple and rapid method to quantify the species by modification of the HPLC system of Macka and co-workers [22].…”

Section: Cl\ /Nh 3 Ci\ /Nh a /Pt\ Nh:~pt\ci/ Nh 3 CL Ci/pt\cimentioning

confidence: 99%

“…The LC method was based on that of Macka [22]. A Shimadzu AEG 220 Libror and Metrohm 654 digital pH meter with a senserox combination pH electrode recorder 120 C assembly were used.…”

Section: Experimental Apparatusmentioning

confidence: 99%

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Determination of cisplatin, transplatin and amminetri-chloroplatinate by high performance liquid chromatography in one run using 4-methyl-2-thiouracil as derivatizing agent

1999

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We have developed a simple, rapid, selective and sensitive method for detecting the antitumour agent cisdiamminedichloroplatinum (II) (cisplatin) (CDDP) and its toxic impurities trans-diamminedichloroplatinum (II) (transplatin) (TDDP) amminetri-chloroplatinat (ATCP) anion using HPLC in one run. By using 4methyl-2-thiouracil (MTU) as a derivatizing agent, new compounds have been formed from the Pt compounds and separated on a ~-Bondapak C1s column with isocratic elution and detection at 315 nm. Reactant concentration, methanol content, pH and the reaction time on yield of derivatives were investigated and the optimum conditions for the detection response were defined. The derivatives of each of the three platinum compounds formed in an acetate buffer solution containing 40 % (v/v) methanol and 0.9 % KC1 solution at pH 3.7 and ambient temperature were only stable for one hour.

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Section: Discussionmentioning

confidence: 99%

Section: Cl\ /Nh 3 Ci\ /Nh a /Pt\ Nh:~pt\ci/ Nh 3 CL Ci/pt\cimentioning

confidence: 99%

Section: Cl\ /Nh 3 Ci\ /Nh a /Pt\ Nh:~pt\ci/ Nh 3 CL Ci/pt\cimentioning

confidence: 99%

“…The LC method was based on that of Macka [22]. A Shimadzu AEG 220 Libror and Metrohm 654 digital pH meter with a senserox combination pH electrode recorder 120 C assembly were used.…”

Section: Experimental Apparatusmentioning

confidence: 99%

See 2 more Smart Citations

Determination of cisplatin, transplatin and amminetri-chloroplatinate by high performance liquid chromatography in one run using 4-methyl-2-thiouracil as derivatizing agent

1999

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“…OSASS (4 mM) and TBAHS (6 mM ) were added to 0.1 M NH 4 Ac solution of the mobile phase [30,31]. The analysis time was drastically shortened and the T values were decreased ( Fig.…”

Section: Simultaneous Adding Of the Two Counter Ion Exchangersmentioning

confidence: 99%

An efficient separation and method development for the quantifying of two basic impurities of Nicergoline by reversed-phase high performance liquid chromatography using ion-pairing counter ions

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2006

Journal of Pharmaceutical and Biomedical Analysis

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Determination of metal ions by capillary electrophoresis

1997

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The increasing use of capillary electrophoresis (CE) in all areas of analytical chemistry has been reflected in the appearance since 1990 of significant numbers of fundamental studies and applications of CE in the area of separations of metal ions. In this article all aspects of separations of metal ions by CE are reviewed and discussed, including general concepts and approaches, sample introduction, complex formation and sample stacking, separation selectivity, the role of kinetics, capillary wall chemistry, detection techniques, method validation, and applications to metal determinations in various matrices.

show abstract

Chromatographic behaviour of some platinum(II) complexes on octadecylsilica dynamically modified with a mixture of a cationic and an anionic amphiphilic modifier

Cited by 17 publications

References 23 publications

Determination of cisplatin, transplatin and amminetri-chloroplatinate by high performance liquid chromatography in one run using 4-methyl-2-thiouracil as derivatizing agent

Determination of cisplatin, transplatin and amminetri-chloroplatinate by high performance liquid chromatography in one run using 4-methyl-2-thiouracil as derivatizing agent

An efficient separation and method development for the quantifying of two basic impurities of Nicergoline by reversed-phase high performance liquid chromatography using ion-pairing counter ions

Determination of metal ions by capillary electrophoresis

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