Chromatographic analysis of griseofulvin and metabolites in biological fluids

Surfactant-mediated dissolution: Contributions of solubility enhancement and relatively low micelle diffusivity

“…Griseofulvin was quantified by HPLC25 using a Waters 717 system equipped with an auto sampler and UV detector (Waters 486), with wavelength set to 254 nm. The column was a Supelco Discovery C18 150 × 4.6 mm (Sigma, St. Louis, MO).…”

Electrospray ionization LC–MS/MS validated method to quantify griseofulvin in human plasma and its application to bioequivalence study

“…These methods are either based on TLC [6][7][8], HPLC [9][10][11][12] or gas chromatography [8,[13][14][15] detection and determination. They involve cumbersome and laborious extraction procedure with large sample volumes and are either less sensitive or time consuming.…”

A Validated Voltammetric Procedure for Quantification of the Antifungal Drug Griseofulvin in Bulk Form, Tablets, and Biological Fluids at a Mercury Electrode

“…A Voltammetric Procedure for Antifungal Drug Griseofulvin limit of quantitation (LOQ) of 2.88 Â 10 29 M (1.016 ng mL 21 ) griseofulvin in spiked human serum were achieved after preconcentration of the drug onto the HMDE for 80 s. The mean percentage recovery of griseofulvin based on the average of six replicate measurements for 4 Â 10 28 M was found to equal 99.28 + 1.88. The obtained results are more sensitive than those obtained by the reported methods (Kamimura et al 1979;Fishcer and Riegelman 1966;Rundberget and Wilkins 2002;Iguchi et al 1966;Zia et al 1980;Kreuzing 1979;Hackett and Dusci 1978;Aboutabl et al 1980). …”

“…Several analytical methods were reported for determination of griseofulvin including spectrophotometry (Sastry et al 1986;Eladl 1993;Sastry et al 1998), thin-layer chromatography (Fischer and Riegelman 1966), gas chromatography (Kamimura et al 1979), liquid chromatography (Rundberget and Wilkins 2002), gas-liquid chromatography (Iguchi et al 1966), highperformance liquid chromatography (Zia et al 1980;Kreuzig 1979;Hackett and Dusci 1978), and PMR (Aboutabl and Hassan 1980). To date, no voltammetric procedure for assay of griseofulvin is found in literature.…”