Choroidal Thinning in Pseudoexfoliation Syndrome Detected by Enhanced Depth Imaging Optical Coherence Tomography

Göktaş, Sertan; Sakarya, Yaşar; Özçimen, Muammer; Sakarya, Rabia; Bukus, Abdulkadir; Ivacık, Ismail Senol; Erdoğan, Erkan

doi:10.5301/ejo.5000460

Cited by 23 publications

(15 citation statements)

References 18 publications

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“…[62496364] More recently, PEX and PEXG eyes have been found to have significantly lower posterior choroidal thicknesses, thought to be related to increased vascular resistance, compared to fellow unaffected eyes and healthy control eyes. [656667686970] As we better understand the molecular makeup of pseudoexfoliation material and its influence on the eye, it will be interesting to evaluate its role in glaucomatous optic neuropathy in PEX patients.…”

Section: Discussionmentioning

confidence: 99%

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

Palko

Sheybani

2017

J Ophthalmic Vis Res

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A systematic literature review was performed evaluating articles examining the effects of pseudoexfoliation syndrome (PEX) and glaucoma (PEXG) on the cornea with a focus on the corneal endothelium. We searched for articles relevant to pseudoexfoliation syndrome, pseudoexfoliation glaucoma and corneal endothelial cell counts using Pubmed, Google Scholar Database, Web of Science and Cochrane Library databases published prior to September of 2016. We then screened the references of these retrieved papers and performed a Web of Science cited reference search. Corneal characteristics analyzed included central corneal thickness (CCT), corneal nerve density, endothelial cell density (ECD), polymegathism, and pleomorphism. These parameters were compared in the following populations: control, PEX, PEXG, and primary open angle glaucoma (POAG). Over 30 observational studies were reviewed. Most studies showed a statistically significant lower ECD in PEX and PEXG populations compared to controls. Overall, PEX eyes had a non-statistically significant trend of lower ECDs compared to PEXG eyes. No consistent trends were found when analyzing differences in CCT amongst control, PEX and PEXG groups. For the few studies that looked at corneal nerve characteristics, the control groups were found to have statistically significantly greater nerve densities than PEX eyes, which had significantly greater densities than PEXG eyes. ECD and corneal nerve densities may be potential metrics for risk-stratifying patients with PEX and PEXG. Our literature review provided further evidence of the significant negative influence PEX has on the cornea, worsening as patients convert to PEXG.

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Section: Discussionmentioning

confidence: 99%

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

Palko

Sheybani

2017

J Ophthalmic Vis Res

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“…With the application of spectral optical coherence tomography (SD-OCT) systems, it is possible to capture the image of the full-thickness of the choroid in vivo [ 9 ]. Goktas et al have found that the macular choroidal thickness in patients with pseudoexfoliation syndrome is lower than that of healthy individuals [ 10 ]. In a study evaluating macular choroidal thickness in the patients with PEX glaucoma, Bayhan et al found the choroidal thickness in the nasal region to be thinner compared with the control group [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Choroidal Thickness in Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Dursun

Özeç

Doğan

et al. 2016

Journal of Ophthalmology

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Purpose. To compare the macular and peripapillary choroidal thickness in eyes with pseudoexfoliation (PEX) syndrome and PEX glaucoma with the normal eyes of healthy controls. Materials and Methods. In this prospective study, 30 eyes of 30 patients with PEX syndrome, 28 eyes of 28 patients with PEX glaucoma, and 30 eyes of 30 age-matched healthy subjects were enrolled. Choroidal thicknesses in the macular and peripapillary areas were measured by using spectral domain optical coherence tomography. Results. Gender, age, and axial length did not significantly differ between the groups (all, p > 0.05). The mean values of choroidal thickness in the macular and peripapillary areas (except the superior quadrant) in the patients with PEX syndrome and PEX glaucoma were lower compared with controls (all p < 0.05). The mean values of the macular and peripapillary choroidal thickness in the PEX glaucoma group were lower compared with PEX syndrome group; however this difference was not significant. Conclusions. The findings of this study revealed that macular and peripapillary choroidal thicknesses were decreased in PEX syndrome and PEX glaucoma cases. The role of choroid in the development of glaucomatous damage in patients with PEX syndrome remains unclear.

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“…In the present study the mean SCT in the PSX and control groups were 249.40 ± 46.28 and 282.46 ± 55.78 µm, respectively. In a similar study by Goktas et al [15 ]using Spectralis, the reported value was 259.40 ± 33 µm in a group of patients whose average age was 75.3 years, although OPP was not calculated in that study.…”

Section: Discussionmentioning

confidence: 84%

Measurement of Subfoveal Choroidal Thickness in Pseudoexfoliation Syndrome Using Enhanced Depth Imaging Optical Coherence Tomography

Vural¹,

Yenerel²,

Okutucu³

et al. 2015

Ophthalmologica

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Background/Aim: Pseudoexfoliation (PSX) syndrome is associated with blood flow disturbances; however, its exact effect on choroidal blood flow and thickness remains to be elucidated. This study compared subfoveal choroidal thickness in normal eyes and in eyes with PSX using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: This prospective, cross-sectional study included 35 eyes of 35 patients (20 males, 15 females) with unilateral or bilateral PSX and 26 eyes of 26 healthy volunteers (13 males, 13 females). Besides a comprehensive ocular and physical examination, all subjects underwent EDI-OCT examination using an Optovue RTVue OCT device (Optovue Inc., Fremont, Calif., USA). Results: The mean choroidal thickness (CT) and ocular perfusion pressure (OPP) were lower in the PSX group than in the healthy controls (249.4 ± 46.3 vs. 282.5 ± 55.8 µm, p = 0.014 and 40.7 ± 5.8 vs. 44.3 ± 4.3 mm Hg, p = 0.007, respectively). In addition, both systolic blood pressure and diastolic blood pressure measurements were lower among the PSX patients. However, no correlation was found between CT and OPP. Conclusion: The findings of this study suggest that PSX is associated with an overall thinning of the subfoveal choroid and a significant decrease in OPP. Future studies are warranted to further examine these relations.

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Choroidal Thinning in Pseudoexfoliation Syndrome Detected by Enhanced Depth Imaging Optical Coherence Tomography

Abstract: In PEX syndrome, there is choroidal thinning subfoveal, temporal, and nasal to the fovea on EDI-OCT. Decreased choroidal thickness, probably due to increased vascular resistance, and reduced blood flow, is seen in PEX syndrome.

Cited by 23 publications

References 18 publications

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

Evaluation of Choroidal Thickness in Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Measurement of Subfoveal Choroidal Thickness in Pseudoexfoliation Syndrome Using Enhanced Depth Imaging Optical Coherence Tomography

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