Measurement of Subfoveal Choroidal Thickness in Pseudoexfoliation Syndrome Using Enhanced Depth Imaging Optical Coherence Tomography

Abstract

Background/Aim: Pseudoexfoliation (PSX) syndrome is associated with blood flow disturbances; however, its exact effect on choroidal blood flow and thickness remains to be elucidated. This study compared subfoveal choroidal thickness in normal eyes and in eyes with PSX using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: This prospective, cross-sectional study included 35 eyes of 35 patients (20 males, 15 females) with unilateral or bilateral PSX and 26 eyes of 26 healthy volunteers (13 males, 13 females). Besides a comprehensive ocular and physical examination, all subjects underwent EDI-OCT examination using an Optovue RTVue OCT device (Optovue Inc., Fremont, Calif., USA). Results: The mean choroidal thickness (CT) and ocular perfusion pressure (OPP) were lower in the PSX group than in the healthy controls (249.4 ± 46.3 vs. 282.5 ± 55.8 µm, p = 0.014 and 40.7 ± 5.8 vs. 44.3 ± 4.3 mm Hg, p = 0.007, respectively). In addition, both systolic blood pressure and diastolic blood pressure measurements were lower among the PSX patients. However, no correlation was found between CT and OPP. Conclusion: The findings of this study suggest that PSX is associated with an overall thinning of the subfoveal choroid and a significant decrease in OPP. Future studies are warranted to further examine these relations.

Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography

“…In our study, we did not find any difference in macular choroidal thickness in the PXS group when compared with the control group after adjusting for age and axial length. In a recent study, Turan-Vural et al 30 compared the subfoveal choroidal thickness of 35 PXS eyes with 26 healthy controls and found a significant decrease in the choroidal thickness in PXS eyes. 30 However, they did not adjust their analysis for confounding variables, including age and axial length, which might be a reason for this discrepancy.…”

Evaluation of Choroidal Thickness in Patients with Pseudoexfoliation Syndrome

“…Literatürde koroid kalınlık öl-çümünün farklı cihazlar ile yapıldığı birçok ça-lışma mevcuttur. 9,[16][17][18][20][21][22] Branchini ve ark., koroid kalınlık ölçümünün farklı cihazlar ile tekrarlanabilir olduğunu göstermişlerdir. 26 Göktaş ve ark., PEX sendromlu hastalarda kontrol grubuna göre koroid kalınlığında incelme saptamış, bunun azalmış oküler kan akımına ve artmış vasküler rezistansa bağlı olabileceğini savunmuşlardır.…”

“…19 Turan-Vural ve ark., PEX sendromlu bireylerde oküler perfüzyon basıncında azalma ve koroid kalınlığında incelme olduğunu göstermiş-lerdir. 17 Eroglu ve ark. ise PEX materyali saptanan ve klinik olarak etkilenmiş gözlerde, etkilenmemiş göz ve kontrol grubuna göre koroidde anlamlı incelme bulmuşlardır.…”

“…[10][11][12] Literatürde çalışmalar olmakla birlikte, psödoeksfo-liatif materyalin koroid kan akımı ve koroid kalınlığına etkisi tartışmalıdır. 5,6,[13][14][15][16][17][18][19][20][21][22] Bu çalışmada, PEX sendromlu hastalarda ve sağlıklı bireylerde makuler koroid kalınlığının değerlendirilip sağlıklı gözlerle karşılaştırılması amaçlanmıştır.…”

Genetics, Diagnosis, and Monitoring of Pseudoexfoliation Glaucoma

“…In 1994, Helbig et al demonstrated progressive degeneration of the iris vasculature on electron microscopy, progressing from the adventitia to the endothelium; they concurrently demonstrated relative hypoxia in the aqueous humor of pseudoexfoliation patients when compared to control (44). More recently, decreased subfoveal choroidal thickness has been demonstrated in pseudoexfoliation eyes, with the suggestion that this may be due to decreased choroidal perfusion related to carotid flow as well as impairment of the choroidal microcirculation (45, 46). Kocaturk et al has reported increased vascular resistance in the ophthalmic artery in pseudoexfoliation glaucoma patients, as identified using color Doppler imaging (47).…”