Chondrosarcoma of bone. The experience at the Istituto Ortopedico Rizzoli.

Gitelis, Steven; Bertoni, Franco; Picci, Piero; Campanacci, Mario

doi:10.2106/00004623-198163080-00006

Cited by 204 publications

(135 citation statements)

References 0 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…While this study verifies the initial grade of the tumor has predictive value, it also demonstrates the tumor is not a static entity. Many of the recurrent tumors increased in grade compared to the initial tumor, and this phenomenon is reported by others [2,6,8,13,18]. The finding is likely a manifestation in part of continued mutation and change in the tumor cells.…”

Section: Discussionsupporting

confidence: 52%

See 1 more Smart Citation

Sixty Percent 10-year Survival of Patients With Chondrosarcoma After Local Recurrence

Lin

Alfawareh

Takeuchi

et al. 2012

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

Background Chondrosarcoma is treated primarily by surgery. The prognosis of patients after local recurrence is not well defined. Both the survival of patients and the risk of further local relapse after surgical treatment of local recurrence have yet to be established. Questions/purposes We determined survival after local recurrence of chondrosarcoma, the rate of further local recurrences, and prognostic factors predicting survival. Patients and Methods We retrospectively reviewed 52 patients treated for locally recurrent conventional chondrosarcoma between 1975 and 2008. All patients had nonmetastatic disease at the time of diagnosis. There were 36 males and 16 females with a median age of 39 years (range, 16-79 years). We analyzed variables affecting overall and disease-free survival. The minimum followup was 12 months unless patients died of disease before 12 months (median, 68 months; range, 4-387 months).Results Thirty patients developed their first local recurrence in axial locations, while 22 developed recurrence in the appendicular skeleton. After local recurrence, overall survival was 74% at 5 years and 60% at 10 years. The mean number of local recurrences was three (range, 1-14).

show abstract

Section: Discussionsupporting

confidence: 52%

“…Fifteen percent to 25% of patients develop local recurrence [2,3,6,8,13,17]. The prognosis for patients after local relapse is not well defined, and few reports [15,18] have studied the survival of patients after local recurrence.…”

Section: Introductionmentioning

confidence: 99%

Sixty Percent 10-year Survival of Patients With Chondrosarcoma After Local Recurrence

Lin

Alfawareh

Takeuchi

et al. 2012

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

show abstract

“…The rate of local recurrence is primarily dependent on the adequacy of surgical therapy rather than on histologic grade (Evans et al 1977, Mankin et al 1980, Gitelis et al 1981. In 1982, Garrison et al reported that inadequate surgical treatment (marginal or intralesional) may lead to a local recurrence in possibly up to 75% of patients.…”

Section: Discussionmentioning

confidence: 99%

Secondary chondrosarcoma in osteochondromas Medullary extension in 15 of 45 cases

Wuisman¹,

Jutte²,

Ozaki

1997

Acta Orthopaedica Scandinavica

View full text Add to dashboard Cite

“…[39][40][41] Radiation therapy has been described for the treatment of surgically inaccessible sites and positive margins as well as in palliative therapy for symptom relief, but it is rarely effective in curing these tumors.…”

Section: Treatmentmentioning

confidence: 99%

Image-guided resection of aggressive sacral tumors

Drazin¹,

Bhamb

Al-Khouja³

et al. 2017

FOC

View full text Add to dashboard Cite

OBJECTIVE The aim of this study was to identify and discuss operative nuances utilizing image guidance in the surgical management of aggressive sacral tumors. METHODS The authors report on their single-institution, multi-surgeon, retrospective case series involving patients with pathology-proven aggressive sacral tumors treated between 2009 and 2016. They also reviewed the literature to identify articles related to aggressive sacral tumors, their diagnosis, and their surgical treatment and discuss the results together with their own experience. Information, including background, imaging, treatment, and surgical pearls, is organized by tumor type. RESULTS Review of the institutional records identified 6 patients with sacral tumors who underwent surgery between 2009 and 2016. All 6 patients were treated with image-guided surgery using cone-beam CT technology (O-arm). The surgical technique used is described in detail, and 2 illustrative cases are presented. From the literature, the authors compiled information about chordomas, chondrosarcomas, giant cell tumors, and osteosarcomas and organized it by tumor type, providing a detailed discussion of background, imaging, and treatment as well as surgical pearls for each tumor type. CONCLUSIONS Aggressive sacral tumors can be an extremely difficult challenge for both the patient and the treating physician. The selected surgical intervention varies depending on the type of tumor, size, and location. Surgery can have profound risks including neural compression, lumbopelvic instability, and suboptimal oncological resection. Focusing on the operative nuances for each type can help prevent many of these complications. Anecdotal evidence is provided that utilization of image-guided surgery to aid in tumor resection at our institution has helped reduce blood loss and the local recurrence rate while preserving function in both malignant and aggressive benign tumors affecting the sacrum.

show abstract

Chondrosarcoma of bone. The experience at the Istituto Ortopedico Rizzoli.

Cited by 204 publications

References 0 publications

Sixty Percent 10-year Survival of Patients With Chondrosarcoma After Local Recurrence

Sixty Percent 10-year Survival of Patients With Chondrosarcoma After Local Recurrence

Secondary chondrosarcoma in osteochondromas Medullary extension in 15 of 45 cases

Image-guided resection of aggressive sacral tumors

Contact Info

Product

Resources

About