Secondary chondrosarcoma in osteochondromas Medullary extension in 15 of 45 cases

Wuisman, P.; Jutte, Paul C.; Ozaki, Toshifumi

doi:10.3109/17453679708996185

Cited by 58 publications

(34 citation statements)

References 17 publications

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“…Because most of these lesions are low-grade CHS, the overall prognosis is good, with long-term survival in 70~90% of patients. Local recurrence rate varies with adequacy of the tumor margins, from 0–15% in widely resected cases to 57~78% in cases with marginal or intralesional resection [37, 48]…”

Section: Secondary Chsmentioning

confidence: 99%

Chondrosarcoma: With Updates on Molecular Genetics

Kim

Cho

Ayala

et al. 2011

Sarcoma

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Chondrosarcoma (CHS) is a malignant cartilage-forming tumor and usually occurs within the medullary canal of long bones and pelvic bones. Based on the morphologic feature alone, a correct diangosis of CHS may be difficult, Therefore, correlation of radiological and clinicopathological features is mandatory in the diagnosis of CHS. The prognosis of CHS is closely related to histologic grading, however, histologic grading may be subjective with high inter-observer variability. In this paper, we present histologic grading system and clinicopathological and radiological findings of conventional CHS. Subtypes of CHSs, such as dedifferentiated, mesenchymal, and clear cell CHSs are also presented. In addition, we introduce updated cytogenetic and molecular genetic findings to expand our understanding of CHS biology. New markers of cell differentiation, proliferation, and cell signaling might offer important therapeutic and prognostic information in near future.

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Section: Secondary Chsmentioning

confidence: 99%

Chondrosarcoma: With Updates on Molecular Genetics

Kim

Cho

Ayala

et al. 2011

Sarcoma

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“…Malignant transformation into a chondrosarcoma occurs in 1-2 % of patients with solitary osteochondromas [8]; therefore, treatment of asymptomatic osteochondromas is not necessary. When the tumor causes pain or neurological complications due to compression, it should be excised at its base.…”

Section: Case Reportmentioning

confidence: 99%

Headache due to an osteochondroma of the axis

2004

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We reported a case of a 42-year-old man with a 3-year history of headache due to a spinal osteochondroma. Repeated neurological evaluation, including EEG studies and CT of the cerebrum, revealed no pathology. More recently the patient presented with persistent headache and a slight limitation of neck motion. MRI studies of the cerebrum including the cervical spine showed a high cervical extradural tumor. Additional CT angiography showed a bony tumor suspected of being a spinal osteochondroma. An en bloc resection of the tumor was performed; histological evaluation confirmed the diagnosis. Immediately after intervention, all symptoms disappeared. In most patients with a spinal osteochondroma, the lesion causes no symptoms, or symptoms are aspecific. Therefore, there is often a significant delay between initial complaints and the diagnosis, as in the current case.

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“…Radiographic features consistent with malignant degeneration included an indistinct superficial border, the presence of a partially mineralized soft-tissue mass, and frequent destruction of the underlying osteochondroma [13]. Wuisman and coauthors mentioned only blurring of the bone borders as an indicator of malignant transformation [24]. Ahmed and coauthors, in a series of 107 patients with secondary chondrosarcomas arising from exostoses, documented irregular margins, heterogeneous mineralization, and a soft-tissue mass as positive indicators of malignant change in an osteochondroma [25].…”

Section: Discussionmentioning

confidence: 99%

Dedifferentiated Peripheral Chondrosarcoma: A Review of Radiologic Characteristics

Henderson

Pala

Angelini

et al. 2013

Sarcoma

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Introduction. Peripheral de-differentiated chondrosarcomas are among the rarest malignant mesenchymal tumors. This tumor's descriptive radiographic characteristics are reported but objective quantification does not exist. This investigation surveyed imaging of peripheral de-differentiated chondrosarcomas to facilitate better recognition of these uncommon tumors. Methods. Database interrogation for peripheral de-differentiated chondrosarcomas was performed; 23 patients were identified and imaging for 18 was reviewed. A musculoskeletal radiologist reviewed all studies for mineralization characteristics; presence of pre-existing osteochondromas; preserved corticomedullary continuity; adjacent cortical obliteration; soft-tissue mass; tumor necrosis; and presence of a cartilage cap. Tumor luminance was measured with computer software. Results. Mineralization was present in 17 tumors. Pre-existing exostoses were evident in nine cases, corticomedullary continuity was preserved in three cases. There was no difference in mineralization or other characteristics based on tumor location. Mean tumor luminance was 94.9 candela/m2. Conclusions. The imaging characteristics described for central de-differentiated chondrosarcomas are similar to the peripheral form of this tumor. Peripheral mineralization with a bimorphic pattern on CT scan and the presence of a soft-tissue mass should be considered worrisome for a peripheral de-differentiated chondrosarcoma, particularly in the setting of multiple hereditary exostoses.

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Secondary chondrosarcoma in osteochondromas Medullary extension in 15 of 45 cases

Cited by 58 publications

References 17 publications

Chondrosarcoma: With Updates on Molecular Genetics

Chondrosarcoma: With Updates on Molecular Genetics

Headache due to an osteochondroma of the axis

Dedifferentiated Peripheral Chondrosarcoma: A Review of Radiologic Characteristics

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