Sixty Percent 10-year Survival of Patients With Chondrosarcoma After Local Recurrence

Abstract

Background Chondrosarcoma is treated primarily by surgery. The prognosis of patients after local recurrence is not well defined. Both the survival of patients and the risk of further local relapse after surgical treatment of local recurrence have yet to be established. Questions/purposes We determined survival after local recurrence of chondrosarcoma, the rate of further local recurrences, and prognostic factors predicting survival. Patients and Methods We retrospectively reviewed 52 patients treated for locally recurrent conventional chondrosarcoma between 1975 and 2008. All patients had nonmetastatic disease at the time of diagnosis. There were 36 males and 16 females with a median age of 39 years (range, 16-79 years). We analyzed variables affecting overall and disease-free survival. The minimum followup was 12 months unless patients died of disease before 12 months (median, 68 months; range, 4-387 months).Results Thirty patients developed their first local recurrence in axial locations, while 22 developed recurrence in the appendicular skeleton. After local recurrence, overall survival was 74% at 5 years and 60% at 10 years. The mean number of local recurrences was three (range, 1-14).

Oncologic outcome after local recurrence of chondrosarcoma: Analysis of prognostic factors

“…Adequacy of surgical margins was associated with first episode of LR in high grade chondrosarcoma patients of the original cohort in this study. Of note, multiple LR in comparison with a single episode of LR was not prognostic for a worse survival (65.6% ± 20.9 vs. 57.5% ± 12, P = 0.384) which was in agreement with a previous study .…”

“…Older age was an independent prognostic factor for poor post‐LR survival in line with a previous study . The worse outcomes seen in older patients may be related to differences in tumor characteristics, with older patients having a propensity for biologically aggressive tumors.…”

“…Less than one-third (9 out of 28) of the patients developed metastasis after LR with median time of 3.3 years (range, 0.1-8.0 years). In line with the previous studies, these results show that development of LR is not always a poor prognostic sign in a substantial number of patients [4,9]. Of note, all of the four patients who underwent metastatectomy were disease free until the last follow-up.…”

“…Post-LR survival of 59% at 10 years of our study is comparable to those of the previous studies [2,4,[6][7][8][9]. The relatively high survival rate after LR suggests that the development of a LR does not necessarily associate with poor survival.…”

Risk stratification for central conventional chondrosarcoma of bone: A novel system predicting risk of metastasis and death in the Cancer Registry of Norway cohort

“…Further subgroup analysis is needed, seeking to find whether this is valid for all CCCS or only the high risk group. Although LR has been linked to increased rates of metastasis and death in CS research, 13,32‐37 this has been performed in mixed CS cohorts and without considering immortal time bias for time dependent variables.…”