Cholinergic system of rats treated with vincristine sulphate and nandrolone decanoate

Martins, Danieli Brolo; Mazzanti, Cinthia M.; Spanevello, Rosélia Maria; Schmatz, Roberta; Junior, Marcos Corrêa; Stefanello, Naiara; Morsch, Vera Maria; Veiga, Angela Patricia Medeiros; Schetinger, Maria Rosa Chitolina; Lopes, Sonia T.A.

doi:10.1007/s00580-009-0948-y

Cited by 3 publications

(2 citation statements)

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“…Some studies have demonstrated the interaction of AAS within the CNS (Johansson et al 2000;Frizon et al 2005;Papazisis et al 2007;Martins et al 2010). Some studies have recently been carried out in the cognitive area, investigating the use of testosterone derivatives in complementary therapy of some central disturbances, like the Alzheimer disease (Kenny et al 2004;Lu et al 2006).…”

Section: Discussionmentioning

confidence: 96%

“…These substances are very popular among athletes and individuals who want to increase their muscle mass, especially teenaged and adult males (Hartgens et al 2001;Iriart and Andrade 2002;Lindqvist 2004). However, biological sciences only recently discovered the medical applications of the AAS, nandrolone decanoate (ND),and reported its potential uses for the treatment of human and animal patients (Basaria et al 2001;Vieira et al 2008;Martins et al 2010), for conditions such as burns (Lindqvist 2004), obstructive pulmonary disease (Schols 2003), breast cancer (Basaria et al 2001), and acquired immunodeficiency syndrome (Cuerda et al 2005), among others.…”

Section: Introductionmentioning

confidence: 99%

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Subchronic administration of nandrolone decanoate in acetylcholinesterase activity in Wistar rats

et al. 2010

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Health sciences have recently discovered the medical uses of nandrolone decanoate (ND), an androgenic anabolic steroid (AAS), and reported its use in human and animal patients. Clinical evidences suggest that the AAS excess may affect the cholinergic system, which is responsible for several vital functions like learning, memory, and the organization of the movements. Thus, our aim is to research the subchronic effect of ND when administered in varying doses on the acetylcholinesterase (AChE) activity in these brain structures: cerebellum (CE), hippocampus, striatum (ST), and cortex of adult rats. We used 36 male Wistar rats, which were divided into six groups (n=6). The groups were divided into: G1-control (physiologic solution), G2-diluents control (only an oleaginous vehicle of vegetal origin-olive oil), G3-0.42 mgkg −1 of ND, G4-1.8 mg kg −1 of ND, G5-4.6 mgkg −1 of ND, and G6-10.0 mg kg −1 of ND. We applied the doses once every week during a 3-week period. The values obtained demonstrated a significant increase in the AChE activity (referring to ST and CE for the 4.6 and 10.0 mgkg −1 doses of ND). The ND causes increase in AChE activity, which could impair neurotransmission and cholinergic modulation.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Subchronic administration of nandrolone decanoate in acetylcholinesterase activity in Wistar rats

et al. 2010

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Neuroprotective Effects of Guarana (Paullinia Cupana Mart.) Against Vincristine in Vitro Exposure

Veloso

Machado

Cadoná³

et al. 2017

J Prev Alz Dis

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Background: Vincristine (VCR) is not a specific chemotherapeutic drug, responsible for cause several side effects. In this sense, many natural products have been studied to reduce this problem. Objetives: To examine the guarana neuroprotective effect in mice brain and cerebellum cells against vincristine (VCR) exposition. Design: An in vitro study was performed using mice brain and cerebellum mice in monolayer culture. First, cells were exposed to VCR (0.009 µM for 24 hours and 0.0007 µM for 72 hours) to measure the cytotoxicity effect. Also, the cellular effect of hydroalcoholic extract of guarana (10; 30; 100 and 300 μg/mL) was evaluated in the same cells in 24 and 72 hours. After that, cells were exposed to VCR and guarana extract to evaluate the neuroprotective effect of guarana. Measurements: Cell viability was analyzed by MTT, Free dsDNA and LHD Assays. Moreover, metabolism oxidative profile was evaluated by reactive oxygen species (ROS), lipoperoxidation (LPO) and catalase (CAT) levels through DCFH-DA, TBARS and Catalase Activity Assays, respectively. Results: Our findings revealed that VCR caused neuronal cytotoxicity by reducing cell viability and increasing ROS and LPO levels. On the other hand, guarana did not cause cell damage in none of tested concentrations. In addition, guarana exhibited a notable protective effect on brain and cerebellum cells exposed to VCR by increasing cell viability, stimulating CAT activity, reducing levels of ROS and LPO. Conclusions: In this sense, guaraná is a remarkable antioxidant fruit that could be a target in new therapies development to reduce VCR neurotoxicity.

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Neuroprotective potential of the Amazonian fruits Euterpe oleracea Mart. and Paullinia cupana Kunth

Costa

Queiroz

Santos

et al. 2023

Braz. J. Pharm. Sci.

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Acai (Euterpe oleracea Mart.) and guarana (Paullinia cupana Kunth) are native species from the Amazon Forest that in folk medicine are used to treat several diseases due to their anti-inflammatory and antioxidant properties. This review brings together findings from different studies on the potential neuroprotective effects of acai and guarana, highlighting the importance of the conservation and sustainable exploitation of the Amazon Forest. A bibliographic survey in the PubMed database retrieved indexed articles written in English that focused on the effects of acai and guarana in in vitro and in vivo models of neurodegenerative diseases. In general, treatment with either acai or guarana decreased neuroinflammation, increased antioxidant responses, ameliorated depression, and protected cells from neurotoxicity mediated by aggregated proteins. The results from these studies suggest that flavonoids, anthocyanins, and carotenoids found in both acai and guarana have therapeutic potential not only for neurodegenerative diseases, but also for depressive disorders. In addition, acai and guarana show beneficial effects in slowing down the physiological aging process. However, toxicity and efficacy studies are still needed to guide the formulation of herbal medicines from acai and guarana.

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Cholinergic system of rats treated with vincristine sulphate and nandrolone decanoate

Abstract: Background: We considered both the indiscriminate use of steroids by top athletes and by physically active individuals.

Cited by 3 publications

References 28 publications

Subchronic administration of nandrolone decanoate in acetylcholinesterase activity in Wistar rats

Subchronic administration of nandrolone decanoate in acetylcholinesterase activity in Wistar rats

Neuroprotective Effects of Guarana (Paullinia Cupana Mart.) Against Vincristine in Vitro Exposure

Neuroprotective potential of the Amazonian fruits Euterpe oleracea Mart. and Paullinia cupana Kunth

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