Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.

Perry, E K; Curtis, Maria; Dick, D J; Candy, J.; Atack, John; Bloxham, C. A.; Blessed, G.; Fairbairn, Andrew; Tomlinson, Bernard E.; Perry, Robert H.

doi:10.1136/jnnp.48.5.413

Cited by 524 publications

(241 citation statements)

References 24 publications

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“…This is consistent with previous reports showing a preservation of neurons in the nucleus basalis of Meynert [3,6]. Dementia is associated with neuronal damage or loss in the nucleus basalis in Alzheimer's disease and Parkinson's disease [8]. The findings in Huntington's disease, however, indicate that damage to this region is not a prerequisite for the development of dementia.…”

Section: Discussionsupporting

confidence: 92%

Brain muscarinic cholinergic receptors in Huntington's disease

et al. 1992

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Summary. Muscarinic cholinergic receptors and choline acetyltransferase (CHAT) activity were studied in postmortem brain tissue from patients with Huntington's disease and matched control subjects. In comparison with controls, reductions in ChAT activity were found in the hippocampus, but not in the temporal cortex in Huntington's disease. Patients with Huntington's disease showed reduced densities of the total number of muscarinic receptors and of M-2 receptors in the hippocampus while the density of M-1 receptors was unaltered. Muscarinic receptor binding was unchanged in the temporal cortex. These results indicate a degeneration in Huntington's disease of the septo-hippocampal cholinergic pathway, but no impairment of the innominato-cortical cholinergic system.

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Section: Discussionsupporting

confidence: 92%

Brain muscarinic cholinergic receptors in Huntington's disease

et al. 1992

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“…The severity of these deficits correlates well with the severity of dementia. 24,25 In a comparative study of patients with AD, DLB and PD, mean midfrontal choline acetyltransferase (chAT) activity was found to be markedly reduced in PD and DLB compared with normal controls and also with those with AD. 26 Functional imaging studies using positron emission tomography (PET) scans and cholinergic markers revealed similar findings: compared with controls, mean cortical AChE activity was lowest in patients with PDD, followed by patients with PD without dementia and AD patients with equal severity of dementia.…”

Section: Biochemical Deficits and Treatment Of Parkinson's Disease Dementioning

confidence: 99%

Dementia Associated with Parkinsons Disease

Emre¹

2007

European Neurological Review

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The classical perception of Parkinson's disease (PD) heavily emphasises its motor aspects, cognitive features and dementia associated with the disease being largely ignored. Epidemiological studies performed in the last few decades revealed the substantially high incidence and prevalence of cognitive impairment and dementia in PD. Clinical studies using EpidemiologyDementia associated with PD has been increasingly better recognised, probably because patients with PD survive for longer than before thanks to modern treatment. Although subtle cognitive deficits can be found in newly diagnosed patients with PD, 1 dementia itself is strongly associated with advanced age and severe disease. 2 In population-based, cross-sectional studies the prevalence of dementia has been reported to be 28-41%. A meta-analysis of 12 carefully selected studies revealed a cross-sectional prevalence of close to 30%. 3 The incidence increases up to six-fold and the cumulative incidence over eight years of follow-up was described to be 78%. 4,5 The longitudinal Sydney study revealed that 15 years after the diagnosis 85% of the patients had cognitive impairment, with 50% fulfilling

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“…In an earlier report by Perry et al documented the similar correlation with cholinergic system [38]. Beyer et al have studied voxel-based morphometry in magnetic resonance imaging on PD patient and found cognitive impairment is linked with the progress of the disease [39].…”

Section: Reviewmentioning

confidence: 85%

Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

Choudhury¹,

Rao²,

R³

et al. 2017

Neuropsychiatry

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While most of the clinical concerns for Parkinson's disease (PD) are limited to the cardinal motor abnormalities, non-motor features like cognitive and psychological anomalies are also acquired ample of importance in last few decades. Progressive research has showcased several obvious incidences of cognitive and psychological anomalies in the pathophysiology of PD. It has been reported that, almost 30% PD sufferers show different degree of cognitive impairment but lack of awareness or negligence makes it difficult to diagnose it, at the initial stage of the disease. As a result, cognitive and psychological impairments continue to increases progressively and deteriorate the quality of life of the patient. It is presumable that, early detection of PD can be achieved by the identification of specific set of cognitive and psychological anomalies and the similar scope might open up new avenue in the non-invasive diagnosis of PD. In the present review, we have accumulated all the timely documentation on cognitive and psychological anomalies in PD and highlighted most of the non-motor features with rational justification for the relevance of their study in the early diagnosis of PD.

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Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.

Cited by 524 publications

References 24 publications

Brain muscarinic cholinergic receptors in Huntington's disease

Brain muscarinic cholinergic receptors in Huntington's disease

Dementia Associated with Parkinsons Disease

Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

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