Choline‐Derivate‐Modified Nanoparticles for Brain‐Targeting Gene Delivery

Li, Jianfeng; Zhou, Lu; Ye, Deyong; Huang, Shixian; Shao, Kun; Huang, Rongqin; Han, Liang; Liu, Yang; Liu, Shuhuan; Ye, Liya; Lou, Jinning; Jiang, Chen

doi:10.1002/adma.201101899

Cited by 75 publications

(52 citation statements)

References 19 publications

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“…However, the fl uorescence signals of the liver and kidney were apparently not captured in the whole body images (Figure 6 A-E). This might be attributed to the deep location of these organs, similar results of which have been reported by Li et al [ 49 ] …”

Section: Biological Applicationssupporting

confidence: 87%

Direct Solvent-Derived Polymer-Coated Nitrogen-Doped Carbon Nanodots with High Water Solubility for Targeted Fluorescence Imaging of Glioma

Wang

Meng

Wang

et al. 2015

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Cancer imaging requires biocompatible and bright contrast-agents with selective and high accumulation in the tumor region but low uptake in normal tissues. Herein, 1-methyl-2-pyrrolidinone (NMP)-derived polymer-coated nitrogen-doped carbon nanodots (pN-CNDs) with a particle size in the range of 5-15 nm are prepared by a facile direct solvothermal reaction. The as-prepared pN-CNDs exhibit stable and adjustable fluorescence and excellent water solubility. Results of a cell viability test (CCK-8) and histology analysis both demonstrate that the pN-CNDs have no obvious cytotoxicity. Most importantly, the pN-CNDs can expediently enter glioma cells in vitro and also mediate glioma fluorescence imaging in vivo with good contrast via elevated passive targeting.

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Section: Biological Applicationssupporting

confidence: 87%

Direct Solvent-Derived Polymer-Coated Nitrogen-Doped Carbon Nanodots with High Water Solubility for Targeted Fluorescence Imaging of Glioma

Wang

Meng

Wang

et al. 2015

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“…2A, the modification of LNP significantly enhanced the permeability of NPs across the BBB at different time point. The P app of LNP-modified NPs which reached 92.43 Â 10 À6 cm/s, was larger than that of some other BBB crossing formulations such as lactoferrin-modified NPs (about 65 Â 10 À6 cm/s) [30] and the synthesized compound 10-conjugated NPs (about 40 Â 10 À6 cm/s) [31]. This indicated that the permeability promoting effect of LNP was more obvious than lactoferrin and compound 10.…”

Section: Transport Of Nps Across the Bbb Monolayermentioning

confidence: 85%

“…Several BBB-crossing strategies have been reported including receptor-based [30,33,34] and transporter-based [4,31] pathways. LNP has been reported to possess the potential for transporting biomolecules across the BBB [28].…”

Section: Transport Of Nps Across the Bbb Monolayermentioning

confidence: 99%

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Enhanced blood–brain barrier penetration and glioma therapy mediated by a new peptide modified gene delivery system

Yao

Wang

et al. 2015

Biomaterials

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“…Several targeted drug delivery systems for brain diseases have recently been developed [5][6][7][8][9][10]. Targeted drug delivery systems can cross the BBB and promote accumulation of antitumor drugs in the brain.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo brain-targeting chemo-photothermal therapy using graphene oxide conjugated with transferrin for Gliomas

et al. 2016

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Current therapies for treating malignant glioma exhibit low therapeutic efficiency because of strong systemic side effects and poor transport across the blood brain barrier (BBB). Herein, we combined targeted chemo-photothermal glioma therapy with a novel multifunctional drug delivery system to overcome these issues. Drug carrier transferrin-conjugated PEGylated nanoscale graphene oxide (TPG) was successfully synthesized and characterized. When loaded on the proposed TPG-based drug delivery (TPGD) system, the anticancer drug doxorubicin could pass through the BBB and improve drug accumulation both in vitro and in vivo. TPGD was found to perform dual functions in chemotherapy and photothermal therapy. Targeted TPGD combination therapy showed higher rates of glioma cell death and prolonged survival of glioma-bearing rats compared with single doxorubicin or PGD therapy. In conclusion, we developed a potential nanoscale drug delivery system for combined therapy of glioma that can effectively decrease side effects and improve therapeutic effects.

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Choline‐Derivate‐Modified Nanoparticles for Brain‐Targeting Gene Delivery

Cited by 75 publications

References 19 publications

Direct Solvent-Derived Polymer-Coated Nitrogen-Doped Carbon Nanodots with High Water Solubility for Targeted Fluorescence Imaging of Glioma

Direct Solvent-Derived Polymer-Coated Nitrogen-Doped Carbon Nanodots with High Water Solubility for Targeted Fluorescence Imaging of Glioma

Enhanced blood–brain barrier penetration and glioma therapy mediated by a new peptide modified gene delivery system

In vitro and in vivo brain-targeting chemo-photothermal therapy using graphene oxide conjugated with transferrin for Gliomas

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