Choline chloride-based deep eutectic solvents as potential solvent for extraction of phenolic compounds from olive leaves: Extraction optimization and solvent characterization

Pontes, Paula Virginia de Almeida; Shiwaku, Isabella Ayumi; Máximo, Guilherme J.; Batista, Eduardo Augusto Caldas

doi:10.1016/j.foodchem.2021.129346

Cited by 108 publications

(65 citation statements)

References 32 publications

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“…The authors attributed this result to stronger hydrogen bond interactions between the chloride anion and proanthocyanidin. de Almeida Pontes et al (2021) reported that HBD in DES affected the phenolic composition in the extracts.…”

Section: Resultsmentioning

confidence: 99%

Ultrasound assisted extraction of phenolic compounds from Capparis Ovata var canescens fruit using deep eutectic solvents

Yazici

Özmen

2022

Food Processing Preservation

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The aim of this study is to develop a green procedure that provides high‐efficiency extraction of phenolic compounds from Capparis Ovata fruit with Deep Eutectic Solvent (DES) using ultrasound‐assisted extraction method. Ten DES combinations were prepared by mixing various proportions of choline chloride (ChCl), Na‐acetate and Na‐citrate with sugar alcohols, carboxylic acid. These DESs were tested as an effective solvent for recovering phenolic compounds. DES composed of lactic acid combining with ChCl showed the highest efficiency of extraction for phenolic compounds. Optimal extraction conditions were found as follows; 20% water in DES, liquid/solid ratio 20:1 (mL/g), temperature 50℃, and extraction time 30 min. The maximum total phenolic content, total flavonoid content, DPPH inhibition percentage, and ferric reducing power capacity values under optimal conditions were 30.55 ± 0.57 mg GAE/g DW, 13.04 ± 0.4 mg QE/g DW, 98.49 ± 2.51% and 1.79 ± 0.04 (absorbance units), respectively. The concentrations of all phenolic compounds determined by chromatographic method have increased under optimal extraction conditions. Practical applications The application of DES in the extraction of the phenolic compound is an innovative approach for environmentally, friendly, low‐costs, and improving extraction efficiency. Caper fruits are known to be rich sources of bioactive compounds. Caper is consumed as food and traditional folk medicines for their health benefits. At previous studies, a green extraction procedure to obtain phenolic compounds from Capparis Ovata var canescens fruit has not been established by using DES. Therefore, this study aimed to improve a green procedure to obtain phenolic compounds with strong antioxidant properties, which could be employed in the food industry. In addition, determination of optimal extraction conditions has been performed to guide large‐scale production.

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Section: Resultsmentioning

confidence: 99%

Ultrasound assisted extraction of phenolic compounds from Capparis Ovata var canescens fruit using deep eutectic solvents

Yazici

Özmen

2022

Food Processing Preservation

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“…The obtained results are consistent with a list of studies performed on the effect of extraction conditions using deep eutectic solvents. For instance, the study of de Almeida Pontes et al [ 41 ] on olive leaves showed an improvement in the extraction of phenolic compounds by increasing extraction temperature (>50 °C). Additionally, it was demonstrated that variation in the amount and composition of deep eutectic solvents contents influences the composition and the quantity of recovery phenolic compounds.…”

Section: Resultsmentioning

confidence: 99%

Extraction of Anthocyanins from Borage (Echium amoenum) Flowers Using Choline Chloride and a Glycerol-Based, Deep Eutectic Solvent: Optimization, Antioxidant Activity, and In Vitro Bioavailability

et al. 2021

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Borage flower (Echium amoenum), an annual herb native to the Mediterranean region, is an excellent source of anthocyanins and is widely used in various forms due to its biological activities. In the present study, a choline chloride and glycerol (CHGLY)-based natural deep eutectic solvent (NADES) was applied in order to extract the anthocyanins from borage flowers. The traditional solvents, including water, methanol, and ethanol, were used to evaluate the efficiency of CHGLY. The results showed that CHGLY was highly efficient compared to the traditional solvents, providing the highest amounts of the total anthocyanin content (TAC), total phenolic content (TPC), total flavonoid content (TFC), individual anthocyanins, and antioxidant activity (DPPH radical scavenging (DPPH) and ferric-reducing antioxidant power (FRAP) assays). The most dominant anthocyanin found in studied borage was cyanidin-3-glucoside, followed by cyanin chloride, cyanidin-3-rutinoside, and pelargonidin-3-glucoside. The bioavailability % was 71.86 ± 0.47%, 77.29 ± 0.57%, 80.22 ± 0.65%, and 90.95 ± 1.01% for cyanidin-3-glucoside, cyanidin-3-rutinoside, by pelargonidin-3-glucoside and cyanin chloride, respectively. However, cyanidin-3-glucoside was the anthocyanin compound showing the highest stability (99.11 ± 1.66%) in the gastrointestinal environment. These results suggested that choline chloride and glycerol-based NADES is not only an efficient, eco-friendly solvent for the extraction of anthocyanins but can also be used to increase the bioavailability of anthocyanins.

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“…In addition, an appropriate water content in DES can enhance mass-/energy-transfer and thereby improve the extraction efficiency of phenolic compounds. However, increasing the water content in DES did not always enhance their extraction efficiency, which may be due to the fact that high contents of water in DES can weaken hydrogen bonds among DESs components, thus altering their viscosity, polarity, and pH [33,36]. Herein, no information focused on how the addition of water content in ChCl-LevA either weakens the formation of hydrogen bonds or affects its extraction efficiency for phenolic compounds.…”

Section: Ft-ir Spectra Of Extraction Solventsmentioning

confidence: 96%

Customized Deep Eutectic Solvents as Green Extractants for Ultrasonic-Assisted Enhanced Extraction of Phenolic Antioxidants from Dogbane Leaf-Tea

Wang

Zhang

et al. 2021

Foods

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This study evaluates the application of eco-friendly deep eutectic solvents (DESs) in the extraction of phenolic antioxidants from dogbane leaf-tea (DLT). The results showed DESs with lower viscosity allowed an efficient extraction of significantly higher contents of total phenolics or flavonoids. An innovative and high-efficient solvent, choline chloride-levulinic acid (ChCl-LevA), was screened and used in ultrasonic-assisted extraction (UAE) of phenolic compounds from DLT. According to full factorial design experimental results, total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity, and anti-α-glucosidase activity (α-GIA) of the DLT extracts were simultaneously optimized by response surface methodology. Sonication temperature and water content in ChCl-LevA were found to be the major factors affecting the TPC, TFC, antioxidant activity, and α-GIA of DLT extracts. Under the optimum parameters (water content in ChCl-LevA was 45%, sonication temperature was 50 °C, and extraction time was 30 min), the measured results for all the responses were obtained as follows: TPC-91.38 ± 7.20 mg GAE/g DW, TFC-84.12 ± 3.47 mg RE/g DW, ABTS+-492 ± 7.33 mmol TE/g DW, FRAP-6235 ± 121 μmol Fe(II)/g DW and α-GIA-230 ± 7.59 mmol AE/g DW, which were consistent with the predicted values. In addition, strongly significant positive correlations were observed between TPC/TFC and bio-activities of the DLT extracts. HPLC results indicated high contents of (-)-epigallocatechin (4272 ± 84.86 μg/g DW), catechin (5268 ± 24.53 μg/g DW), isoquercitrin (3500 ± 86.07 μg/g DW), kaempferol 3-O-rutinoside (3717 ± 97.71 μg/g DW), and protocatechuic acid (644 ± 1.65 μg/g DW) were observed in the DLT extracts. In contrast to other extraction methods, ChCl-LevA-based UAE yielded higher TPC, TFC, individual phenolic contents, stronger antioxidant activity, and α-GIA. Scanning electron microscope (SEM) analysis further confirmed that ChCl-LevA-based UAE enhanced the disruption of cell wall structure, thereby making more phenolic antioxidants released from DLT. In short, ChCl-LevA-based UAE was confirmed to be an innovative and high-efficient method for extraction of phenolic antioxidants from DLT. Dogbane leaves can be considered as a good tea source rich in natural antioxidants.

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Choline chloride-based deep eutectic solvents as potential solvent for extraction of phenolic compounds from olive leaves: Extraction optimization and solvent characterization

Cited by 108 publications

References 32 publications

Ultrasound assisted extraction of phenolic compounds from Capparis Ovata var canescens fruit using deep eutectic solvents

Ultrasound assisted extraction of phenolic compounds from Capparis Ovata var canescens fruit using deep eutectic solvents

Extraction of Anthocyanins from Borage (Echium amoenum) Flowers Using Choline Chloride and a Glycerol-Based, Deep Eutectic Solvent: Optimization, Antioxidant Activity, and In Vitro Bioavailability

Customized Deep Eutectic Solvents as Green Extractants for Ultrasonic-Assisted Enhanced Extraction of Phenolic Antioxidants from Dogbane Leaf-Tea

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