Cholestin (Monascus purpureus rice) inhibits homocysteine-induced reactive oxygen species generation, nuclear factor-κB activation, and vascular cell adhesion molecule-1 expression in human aortic endothelial cells

Lin, Chia‐Pin; Chen, Yung‐Hsiang; Chen, Jaw Wen; Leu, Hsin Bang; Liu, Tsan Zon; Liu, Po Len; Huang, Song Lih

doi:10.1007/s11373-007-9212-0

Cited by 25 publications

(31 citation statements)

References 57 publications

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“…Epidemiological studies indicate that RYR consumption is associated with reduced coronary heart disease risk [29, 30]. In vitro investigations have indicated that RYR can inhibit several key events of the atherogenic process, such as vascular smooth muscle and endothelial cell dysfunction by redox-sensitive mechanisms [15, 16, 31]. RYR contains chemicals that are similar to prescription statin medications including monacolin K (the same structure as the drug lovastatin).…”

Section: Discussionmentioning

confidence: 99%

“…RYR (LipoCol Forte) was obtained from NatureWise Biotech & Medicals Corporation (Taipei, Taiwan) and extracted at room temperature [15, 16]. Final concentration of solvents in following studies was always less than 0.5% to avoid potential interference.…”

Section: Methodsmentioning

confidence: 99%

“…RYR has also been shown to have free radical scavenging abilities and can protect the function of endothelium through antioxidative and anti-inflammatory mechanisms [15]. Moreover, a previous study showed that RYR inhibited homocysteine-induced endothelial adhesion via intracellular ROS reduction [16]. …”

Section: Introductionmentioning

confidence: 99%

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Red Yeast Rice Protects Circulating Bone Marrow‐Derived Proangiogenic Cells against High‐Glucose‐Induced Senescence and Oxidative Stress: The Role of Heme Oxygenase‐1

Liu

Chen

et al. 2017

Oxidative Medicine and Cellular Longevity

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The inflammation and oxidative stress of bone marrow-derived proangiogenic cells (PACs), also named endothelial progenitor cells, triggered by hyperglycemia contributes significantly to vascular dysfunction. There is supporting evidence that the consumption of red yeast rice (RYR; Monascus purpureus-fermented rice) reduces the vascular complications of diabetes; however, the underlying mechanism remains unclear. This study aimed to elucidate the effects of RYR extract in PACs, focusing particularly on the role of a potent antioxidative enzyme, heme oxygenase-1 (HO-1). We found that treatment with RYR extract induced nuclear factor erythroid-2-related factor nuclear translocation and HO-1 mRNA and protein levels in PACs. RYR extract inhibited high-glucose-induced (30 mM) PAC senescence and the development of reactive oxygen species (ROS) in a dose-dependent manner. The HO-1 inducer cobalt protoporphyrin IX also decreased high-glucose-induced cell senescence and oxidative stress, whereas the HO-1 enzyme inhibitor zinc protoporphyrin IX and HO-1 small interfering RNA significantly reversed RYR extract-caused inhibition of senescence and reduction of oxidative stress in high-glucose-treated PACs. These results suggest that RYR extract serves as alternative and complementary medicine in the treatment of these diseases, by inducing HO-1, thereby decreasing the vascular complications of diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Red Yeast Rice Protects Circulating Bone Marrow‐Derived Proangiogenic Cells against High‐Glucose‐Induced Senescence and Oxidative Stress: The Role of Heme Oxygenase‐1

Liu

Chen

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…The current studies showed Hongqu contained many kind of useful compounds, such as monacolins (a group of antihyper-cholesterolemic agent), GABA (a kind of hypotensive agent) and a group of edible pigments (widely used as a natural food colorant) (Lin et al 2008a). Recent studies demonstrated that Cholestin (Monascus purpureus rice) may be a potential implication to attenuate homocysteine-stimulated activation of the endothelium (Lin et al 2008b) and M. purpureus rice may be an effective and economic treatment strategy for nephrotic dyslipidemia (Gheith et al 2008). Therefore, more research was needed regarding the utility of Monascus species.…”

Section: Introductionmentioning

confidence: 89%

Characteristic analysis of transformants in T-DNA mutation library of Monascus ruber

Shao

Ding

Zhao

et al. 2009

World J Microbiol Biotechnol

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Monascus ruber, a red mold species, has been widely used in the fields of food and medicine. In this research, we transformed Monascus ruber spores using Agrobacterium tumefaciens as a tool for random insertional mutagenesis with the hygromycin phosphotransferase gene as the selected marker. Three types of mutants including citrinin-producing mutants, mutants with abnormal aerial hyphae and pigment change mutants were screened for molecular analysis. Southern blot analysis showed that more than 83.3% of transformants contained single T-DNA insertions. The genomic DNA segments of the transformants flanking the T-DNA could be amplified from their left borders with TAIL-PCR. Homologous comparison using the Blast tool showed that none of the isolated DNA sequences had any similarity to each other, suggesting that the T-DNA was randomly integrated into the fungal genome, which provided the hypothetical reason for the variant phenotypes of the transformants. The successful creation of transformants with a single T-DNA tag insertion may help us to clone functional genes related to the metabolism and differentiation of Monascus spp., which will greatly facilitate the molecular analysis of this important fungus and the improvement of strains at the genetic level.

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“…Hyperhomocysteinemia is associated with dysfunction and risk factor of cardiovascular diseases. Lin et al (2008) investigated the effect of cholestin extract on the expression of vascular cell-adhesion molecule-1 (VCAM-1) by homocysteine (HCY) treated human aortic endothelial cells. The experiment showed that RYR extract significantly suppresses the cellular binding of human monocytic cells to HCY stimulated endothelial adhesion.…”

Section: Role Of Ryr In Cvdmentioning

confidence: 99%

Health Benefits and Clinical Impact of Major Nutrient, Red Yeast Rice: A Review

Kalaivani¹,

Sabitha²,

Kalaiselvan³

et al. 2009

Food Bioprocess Technol

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Chinese red yeast rice (RYR), a natural food obtained after fermenting rice with Monascus purpureus. RYR contains unsaturated fatty acids, sterols, B-complex vitamins and monacolins with antioxidant properties. Scientific evidences showed that fermented RYR proved to be effective for the management of cholesterol, diabetes, cardiovascular disease (CVD) and also for the prevention of cancer. This review article describe about the usage of RYR in human being.

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Cholestin (Monascus purpureus rice) inhibits homocysteine-induced reactive oxygen species generation, nuclear factor-κB activation, and vascular cell adhesion molecule-1 expression in human aortic endothelial cells

Cited by 25 publications

References 57 publications

Red Yeast Rice Protects Circulating Bone Marrow‐Derived Proangiogenic Cells against High‐Glucose‐Induced Senescence and Oxidative Stress: The Role of Heme Oxygenase‐1

Red Yeast Rice Protects Circulating Bone Marrow‐Derived Proangiogenic Cells against High‐Glucose‐Induced Senescence and Oxidative Stress: The Role of Heme Oxygenase‐1

Characteristic analysis of transformants in T-DNA mutation library of Monascus ruber

Health Benefits and Clinical Impact of Major Nutrient, Red Yeast Rice: A Review

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