Cholesterol metabolism. 5. The excretion of acids after cholesterol ingestion in rats

Edwards, D. C.; Cook, Robert P.

doi:10.1042/bj0610671

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1955

1958

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Cited by 5 publications

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“…The acidic fraction obtained by extracting the lipids recovered from the lumen contents with sodium bicarbonate shows that a more extensive degradation of the molecule has taken place. Part of this material probably arises from ergosterol, absorbed, metabolized in the liver and excreted as a bile acid in a similar manner to the metabolism of ergosterol (Hanahan & Al-Wakil, 1953) and cholesterol (Bloch, Berg & Rittenberg, 1943;Bergstrom, 1953;, and the remainder by metabolism in the lumen of the intestine (Edwards & Cook, 1955).…”

Section: Discussionmentioning

confidence: 99%

Sterol metabolism. 2. The absorption and metabolism of [14C]ergosterol in the guinea pig

Glover

Leat

Morton

1957

Biochemical Journal

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I957 SUMMARYA method for the biosynthesis of [14C]ergosterol from sodium [methyl-14C]acetate in the mould Carpentete8 brefeldianum Dodge is described. The specific activity of the [14C]ergosterol obtained was 0 1-0 3 pc/mg., and the total yield of radiocarbon was 2-6 %. The specific activity of the [methyl-14C]acetate used before dilution was 38 ,uc/mg. We wish to thank the Medical Research Council for financial support.

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Section: Discussionmentioning

confidence: 99%