Cholesterol — A marker of nutritional status in mild to moderate heart failure

Araújo, José Paulo; Friões, Fernando; Azevedo, Ana; Lourenço, Patrícia; Rocha-Gonçalves, Francisco; Ferreira, António; Bettencourt, Paulo

doi:10.1016/j.ijcard.2007.05.026

Cited by 26 publications

(18 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, statins were used in only 53% against 80% in the control group (p = 0.004); this suggests that the real difference between cholesterol levels without pharmacological intervention is certainly higher. Low cholesterol has been described as an indicator of nutritional status in mild to moderate CHF [23]; the above results suggest that this association may be expanded to cachectic patients.…”

Section: Discussionmentioning

confidence: 66%

Nutritional markers and prognosis in cardiac cachexia

Araújo

Lourenço

Rocha-Gonçalves

et al. 2011

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 66%

Nutritional markers and prognosis in cardiac cachexia

Araújo

Lourenço

Rocha-Gonçalves

et al. 2011

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

“…Hypercholesterolemia showed an unexpected association with better functional outcomes, which may reflect better nutritional or health status among those with higher total cholesterol, 55–57 or a protective effect of statins on vascular events (20% of those diagnosed with hypercholesterolemia used statins). 58 …”

Section: Discussionmentioning

confidence: 99%

Diabetes predicts long-term disability in an elderly urban cohort: the Northern Manhattan Study

Dhamoon

Moon

Paik

et al. 2014

Annals of Epidemiology

View full text Add to dashboard Cite

Purpose There is limited data on vascular predictors of long-term disability in Hispanics. We hypothesized: 1) functional status declines over time 2) vascular risk factors predict functional decline. Methods The Northern Manhattan Study contains a population-based study of 3298 stroke-free individuals ≥40 years of age, followed for median 11 years. The Barthel index (BI) was assessed annually. Generalized estimating equations and Cox models were adjusted for demographic, medical, and social risk factors. Stroke and myocardial infarction occurring during follow-up were censored in sensitivity analysis. Secondarily, motor and non-motor domains of the BI were analyzed. Results Mean age (standard deviation) of the cohort (n=3298) was 69.2 (10) years, 37% were male, 52% Hispanic, 22% diabetic, and 74% hypertensive. There was a mean annual decline of 1.02 BI points (p<0.0001). Predictors of decline in BI included age, female sex, diabetes, depression, and normocholesterolemia. Results did not change with censoring. We found similar predictors of BI for motor and non-motor domains. Conclusion In this large, population-based, multi-ethnic study with long-term follow-up, we found a 1% mean decline in function per year that did not change when vascular events were censored. Diabetes predicted functional decline in the absence of clinical vascular events.

show abstract

“…16e18 Low total cholesterol may reflect a state of malnutrition and cachexia, and lower body mass index and serum albumin are linked with low cholesterol in patients with HF, irrespective of statin therapy. 19,20 These same nutritional parameters have also been associated with risk for mortality. 21e23 Our study verified a link between lower cholesterol and lower albumin in patients hospitalized for HF ( Figure 5).…”

Section: Discussionmentioning

confidence: 99%