Cholecystectomy as a risk factor of non-alcoholic fatty liver disease progression

Bueverov, A O

doi:10.26442/20751753.2019.8.190503

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Существует тесная физиологическая взаимосвязь желчного пузыря с функцией печени, кишечника, поджелудочной железы. Желчный пузырь поддерживает метаболический гомеостаз холестерина и триглицеридов, регулирует энтерогепатическую циркуляцию желчных кислот, метаболическую активность микробиома, осуществляет двигательную функцию, а его удаление нарушает метаболические процессы организма в целом [4,5].…”

Section: Discussionunclassified

“…Холецистэктомия, проведенная по четко разработанным показаниям, не вызывает вопросов, но выполненная, «профилактически», без достаточных оснований пациентам с бессимптомной ЖКБ вероятно нецелесообразна [4].…”

Section: Discussionunclassified

“…В настоящее время появились экспериментальные и клинические данные о связи холецистэктомии с прогресированием НАЖБП [4].…”

Section: Introductionunclassified

“…Желчный пузырь является важным звеном связи печени, кишечника, поджелудочной железы, поддерживая метаболический гомеостаз холестерина и триглицеридов, регулируя энтерогепатическую циркуляцию желчных кислот, метаболическую активность микробиома, осуществляя двигательную функцию, а его удаление нарушает метаболические процессы организма в целом. Холецистэктомия, проведенная по четко разработанным показаниям, не вызывает вопросов, но выполненная, «профилактически», без достаточных оснований, пациентам с бессимптомной ЖКБ вероятно нецелесообразна [4].…”

Section: Introductionunclassified

See 3 more Smart Citations

Clinical and functional state of the pancreas, liver, and intestinal microbiota in patients with chronic biliary-dependent pancreatitis after cholecystectomy

Fayzova,

Fedorov,

Sataev

et al. 2023

jour

View full text Add to dashboard Cite

The purpose of the study: To evaluate the clinical and functional state of the pancreas, liver and intestinal microbiota in patients with chronic biliary- dependent pancreatitis (CKD) after cholecystectomy.Materials and methods. 110 patients with CKD were examined, who were divided into 2 groups: group 1–58 patients (CKD) with a history of cholecystectomy. Group 2–52 patients with CKD with concomitant GI. The control group consisted of 35 practically healthy people. Patients with CKD with preserved gallbladder formed a comparison group with the main group. Cholecystectomy was performed according to urgent indications in most cases, but in some cases it was performed “prophylactically” with asymptomatic GI.All patients underwent:• ultrasound elastometry of the liver on the device “FibroScan” (“EchoSens”, France).• the study of the ability of cells to produce cytokines — TNF-a and TGF-b was determined by the enzyme immunoassay using test systems manufactured by the company “Cytokine” (St. Petersburg) and the company “R&D systems” (USA).• study of the concentration of pancreatic elastase-1 in feces by ELISA using test systems of the company “ScheBoBiotech” (Germany).• determination of the absolute and relative content of FGC (C2-C4) by gas-liquid chromatographic analysis in blood serum and faeces on the Crystal 2000 M chromatograph.Conclusion. In patients with CKD with a history of cholecystectomy, there are more significant violations of the metabolic activity of the intestinal microflora, lipid metabolism, liver fibrosis indicators, the severity of external secretory pancreatic insufficiency (VSN pancreas), which is accompanied by an increase in cytokine levels: TGF-b and TNF-a, an increase in the absolute content of short- chain fatty acids (FFA) in blood serum and feces and multidirectional changes in their spectrum, depending on the severity of the pancreatic VSN, the stage of liver steatosis, cholesterol levels compared with those of patients with CKD with preserved LC.

show abstract

Section: Discussionunclassified

Section: Introductionunclassified

See 2 more Smart Citations

Clinical and functional state of the pancreas, liver, and intestinal microbiota in patients with chronic biliary-dependent pancreatitis after cholecystectomy

Fayzova,

Fedorov,

Sataev

et al. 2023

jour

View full text Add to dashboard Cite

show abstract

Criteria of Formation of Fatty Liver Disease in Individuals of Different Age Groups in the Long-Term Period after Minimally Invasive Cholecystectomy

Ambartsumyan,

Chumak,

Deryagina

et al. 2023

I.P. Pavlov Russian Medical Biological Herald

View full text Add to dashboard Cite

INTRODUCTION: Despite the technical advance in medicine and the use of minimally invasive laparoscopic techniques, complications of cholecystectomy considerably reduce the quality of life of the operated patients. Development of the most common and severe complication fatty liver disease (FLD) is difficult to predict due to numerous factors that influence its formation. AIM: To identify prognostic criteria of formation of FLD in the long-term period after cholecystectomy and to scientifically substantiate their significance. MATERIALS AND METHODS: To identify prognostic criteria of formation of FLD in the long-term period after minimally invasive cholecystectomy, 330 patients (159 men and 171 women) who underwent surgical treatment, were examined. Anthropometric data, hemodynamic parameters were evaluated, autonomic index was calculated. US evaluation of choledoch and Elastography of the liver, magnetic resonance tomography of the liver and magnetic resonance cholangiopancreatography were performed. Using chromatography-mass-spectrometry, microbial markers of parietal microbiome of the intestine were determined. RESULTS: Parameters of body mass index indicate the interrelation between the formation of FLD and increased body mass in patients of older age. In the first group with FLD, sympathetic status prevailed, and in the control group of the same age, parasympathicotonia was predominating. At the older age, in the second and third subgroup, the autonomic regulation did not influence the formation of FLD. The choledoch diameter in men and women with FLD of the first age subgroup was greater relative to patients of the control group and of the preoperative period and also relative to older patients of the same group. In the long-term period after cholecystectomy in the group with fatty liver disease, the opportunistic microflora prevailed over essential one, and aerobic microflora over anaerobic one. Besides, increased amount of fungi and viruses was noted, as well as a change in the distribution of obligate microflora due to decrease in the content of eubacteria and predomination of lactobacteria over bifidobacteria in the parietal layer of the intestine. In the individuals of older age, reduction of the obligate and increase in the opportunistic microflora including aerobic one, was noted. CONCLUSIONS: Age, autonomic regulation and body mass have a significant influence on the formation of FLD in the long-term period after cholecystectomy. In the group of older patients, the influence of the autonomic regulation is lower, and increase in body mass is higher than in younger individuals.

show abstract

Prognosis of a High Risk of Non-Alcoholic Fatty Liver Disease in the Long-Term Period of Laparoscopic Cholecystectomy in the Elderly and Senile

Амбарцумян,

Козлов,

Пятибрат

et al. 2024

Успехи Геронтологии

View full text Add to dashboard Cite

После холецистэктомии больные пожилого возраста требуют особого внимания из-за влияния инволюционных процессов в организме на формирование осложнений. Для выявления прогностических критериев формирования неалкогольной жировой болезни печени (НАЖБП) в отдаленном периоде мини-инвазивной холецистэктомии были обследованы 159 мужчин. Нарушение регуляции желчевыводящих путей определяли с помощью магнитно-резонансной хoлaнгиoпaнкреатoграфии, эластографии и МРТ печени. Микробные маркеры пристеночного микробиома кишечника определяли с помощью хромато-масс-спектрометрии. Выявлена взаимосвязь повышения ИМТ со снижением количества облигатного микробиома (r=–0,43, p<0,050), а также с формированием НАЖБП у пожилых пациентов. Определены особенности вегетативной регуляции у пожилых лиц с НАЖБП. Доказано, что в пожилом возрасте снижение количества облигатной анаэробной ассоциации микроорганизмов тонкой кишки (в среднем с 15 659 до 7 630 кл/г•105 у лиц 2-й возрастной подгруппы и с 14 571 до 7 837 кл/г•105 — в 3-й) является предиктором НАЖБП. Разработанный на основании анализа высокоинформативных признаков прогностический алгоритм позволяет с точностью не ниже 75 % выявить высокий риск формирования НАЖБП в отдалённом периоде холецистэктомии. After cholecystectomy, elderly patients require special attention, due to the influence of involution processes in the body on the formation of complications. To identify prognostic criteria for the formation of fatty liver degeneration in the long-term period of minimally invasive cholecystectomy, 159 men were examined. Dysregulation of the biliary tract was determined using magnetic resonance cholangiopancreatography, elastography and magnetic resonance imaging of the liver. Microbial markers of the wall microbiome of the intestine were determined using chromatography-mass spectrometry. The relationship between an increase in body mass index and a decrease in the amount of obligate microbiome (r=–0,43, p<0,050), as well as with the formation of fatty liver degeneration in elderly patients, was revealed. The features of vegetative regulation in elderly people with fatty liver degeneration have been determined. It has been proven that in old age, a decrease in the number of obligate anaerobic association of microorganisms of the small intestine (on average from 15 659 to 7 630 in persons of the 2nd age subgroup and from 1 457 to 17 837 in the 3rd) is a predictor of fatty liver degeneration. The prognostic algorithm developed on the basis of the analysis of highly informative signs makes it possible to identify with an accuracy of at least 75 % a high risk of fatty liver degeneration in the long-term period of cholecystectomy.

show abstract

Cholecystectomy as a risk factor of non-alcoholic fatty liver disease progression

Cited by 3 publications

References 0 publications

Clinical and functional state of the pancreas, liver, and intestinal microbiota in patients with chronic biliary-dependent pancreatitis after cholecystectomy

Clinical and functional state of the pancreas, liver, and intestinal microbiota in patients with chronic biliary-dependent pancreatitis after cholecystectomy

Criteria of Formation of Fatty Liver Disease in Individuals of Different Age Groups in the Long-Term Period after Minimally Invasive Cholecystectomy

Prognosis of a High Risk of Non-Alcoholic Fatty Liver Disease in the Long-Term Period of Laparoscopic Cholecystectomy in the Elderly and Senile

Contact Info

Product

Resources

About