Cholangiocarcinoma and Squamous Cell Carcinoma of the Stratified Epithelial Portion of the Stomach in a Horse: A Case Report

Pizzigatti, Dietrich; Batista, Fernando Arévalo; Martins, Charles Ferreira; Ribeiro, Olímpio Crisóstomo; Nunes, Marcelo Monteiro; Müller, Thiago Rinaldi

doi:10.1016/j.jevs.2010.11.011

Cited by 4 publications

(12 citation statements)

References 14 publications

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“…1997; Pizzigatti et al . 2011). Presence of neoplastic cells in the abdominal cavity occurs once the tumour has infiltrated the serosal surface of the stomach (McKenzie et al .…”

Section: Discussionmentioning

confidence: 99%

“…1997; Schleining and Voss 2004; Pizzigatti et al . 2011). The clinical signs detected prior to diagnosis are quite unspecific.…”

Section: Discussionmentioning

confidence: 99%

“…1997; Schleining and Voss 2004; Pizzigatti et al . 2011), abdominal ultrasonography was not frequently performed because the technique was less routinely used in the past. This technique is also useful in performing ultrasound‐guided biopsies.…”

Section: Discussionmentioning

confidence: 99%

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Gastric squamous cell carcinoma in the horse: Seven cases (2009–2019)

Ferrer

Nolf²,

Belluco

et al. 2020

Equine Veterinary Education

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Summary This report describes gastric squamous cell carcinoma (GSCC) in seven horses. It records the clinical signs, treatment and outcomes. Main clinical signs were mostly nonspecific and included weight loss, anorexia, fever, tachycardia and tachypnoea. Some more suggestive clinical signs were observed such as recurrent choke, halitosis and hypersalivation. Chronic anaemia and hypoalbuminaemia were common findings. Gastroscopy identified a gastric mass in four cases (57.1%); however, visualisation of the stomach was precluded in the other three horses due to distal oesophageal neoplastic infiltration and compression. Gastric wall thickening was noticed using abdominal ultrasonography in four horses (57.1%). Neoplastic cells could only be detected in the peritoneal fluid of 2 out of 7 horses. Endoscopic‐guided or transabdominal ultrasound‐guided biopsies allowed an ante‐mortem diagnosis in three horses (42.8%). Gastric masses were identified at post‐mortem examination and metastasis were confirmed in the liver and/or the spleen for 4/4 cases. In the cases for which palliative therapy was attempted, most of the horses were subjected to euthanasia within 4 weeks. In conclusion, GSCC is an uncommon neoplastic disease in horses. A combination of diagnostic tests is often necessary to achieve a diagnosis, which is frequently only made late in the course of the disease. As a result, GSCC is commonly associated with a poor short‐term prognosis.

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“…1997; Pizzigatti et al . 2011). Presence of neoplastic cells in the abdominal cavity occurs once the tumour has infiltrated the serosal surface of the stomach (McKenzie et al .…”

Section: Discussionmentioning

confidence: 99%

“…1997; Schleining and Voss 2004; Pizzigatti et al . 2011). The clinical signs detected prior to diagnosis are quite unspecific.…”

Section: Discussionmentioning

confidence: 99%

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Gastric squamous cell carcinoma in the horse: Seven cases (2009–2019)

Ferrer

Nolf²,

Belluco

et al. 2020

Equine Veterinary Education

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“…1,4 CC typically occurs in older animals, with a reported age of 11-23 y, and is only reported sporadically (Table 1). 4,7,12,20,24,29,[33][34][35]42 A combined or mixed HCC and CC have been reported in an 18-y-old Thoroughbred mare. A CC with a concurrent gastric squamous cell carcinoma was also described in an 11-y-old mixedbreed mare.…”

mentioning

confidence: 99%

“…A CC with a concurrent gastric squamous cell carcinoma was also described in an 11-y-old mixedbreed mare. 20,29 Consistent clinicopathologic findings associated with CC in species other than cats and dogs are lacking due to insufficient published information. 5 The clinical signs associated with CC in horses rely on scattered documented cases and are nonspecific and difficult to recognize due to their slow progression.…”

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confidence: 99%

Intrahepatic mucinous cholangiocarcinoma with recurrent colic in a horse case report and literature review of cholangiocarcinoma in horses

Barrantes Murillo,

Cattley,

Cullen

et al. 2024

J VET Diagn Invest

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A 17-y-old Arabian mare was presented to the Auburn Large Animal Veterinary Teaching Hospital with a long-term history of intermittent mild recurrent colic that responded to medical treatment. CBC revealed mild lymphopenia; serum biochemistry findings were of increased gamma-glutamyl transferase and creatine kinase activities, hyperferremia, hyperglycemia, hypomagnesemia, and hypokalemia. Abdominocentesis was compatible with low-protein transudate. Due to the progression and duration of clinical signs, the owner elected euthanasia. Postmortem examination and histopathology confirmed a cholangiocarcinoma. The neoplastic cells were arranged in large cysts containing lakes of mucin that comprised 90% of the tumor volume; thus, a mucinous variant was determined. The neoplastic cells had strong cytoplasmic immunolabeling for cytokeratin 19 and lacked immunolabeling for hepatocyte paraffin 1, supporting bile duct origin. Cholangiocarcinomas are infrequent tumors in horses with nonspecific and slow progressive clinical signs, including recurrent colic. Mucinous cholangiocarcinomas are seldom reported in veterinary medicine and, to our knowledge, have not been reported previously in horses.

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Diseases of the Liver and Liver Failure

Mair

Divers

2017

The Equine Acute Abdomen

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Cholangiocarcinoma and Squamous Cell Carcinoma of the Stratified Epithelial Portion of the Stomach in a Horse: A Case Report

Cited by 4 publications

References 14 publications

Gastric squamous cell carcinoma in the horse: Seven cases (2009–2019)

Gastric squamous cell carcinoma in the horse: Seven cases (2009–2019)

Intrahepatic mucinous cholangiocarcinoma with recurrent colic in a horse case report and literature review of cholangiocarcinoma in horses

Diseases of the Liver and Liver Failure

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