Chloroquine Induced Oxidative Stress in Male Albino Mice: RCT

Abstract

Many drugs have been found to induce oxidative stress. Oxidative stress is responsible for a large number of diseases. Chloroquine is one of the drugs, which can induce oxidative stress, when it is given at higher dose. Purpose: To find the effect of chloroquine as stress inducer on albino mice. Study Design: Randomized clinical trial. Methodology: Sixty male albino mice were taken into this randomized controlled study. Those were divided into two groups of 30 each. Group A was the control group while group B mice were given single oral dose of 970 mg/kg of body weight of chloroquine on 9th day of experiment. Terminal intracardiac blood sample was obtained on 17th day of experiment. Statistical analysis: SPSS version 23 was used for data analysis. Results: When results of group B were compared with those of group A, there was highly significant (p= 0.000) rise in serum malondialdehyde level and highly significant (p= 0.000) decrease in serum glutathione peroxidase level. Conclusion: It was concluded that Chloroquine induces oxidative stress when it is given at the dose of 970 mg/kg of body weight in mice. Keywords: Chloroquine, Oxidative Stress and Malondialdehyde.