Chlorogenic acid from honeysuckle improves hepatic lipid dysregulation and modulates hepatic fatty acid composition in rats with chronic endotoxin infusion

Abstract

Chlorogenic acid as a natural hydroxycinnamic acid has protective effect for liver. Endotoxin induced metabolic disorder, such as lipid dysregulation and hyperlipidemia. In this study, we investigated the effect of chlorogenic acid in rats with chronic endotoxin infusion. The Sprague-Dawley rats with lipid metabolic disorder (LD group) were intraperitoneally injected endotoxin. And the rats of chlorogenic acid-LD group were daily received chlorogenic acid by intragastric administration. In chlorogenic acid-LD group, the area of visceral adipocyte was decreased and liver injury was ameliorated, as compared to LD group. In chlorogenic acid-LD group, serum triglycerides, free fatty acids, hepatic triglycerides and cholesterol were decreased, the proportion of C20:1, C24:1 and C18:3n-6, Δ9-18 and Δ6-desaturase activity index in the liver were decreased, and the proportion of C18:3n-3 acid was increased, compared to the LD group. Moreover, levels of phosphorylated AMP-activated protein kinase, carnitine palmitoyltransferase-I, and fatty acid β-oxidation were increased in chlorogenic acid-LD group compared to LD rats, whereas levels of fatty acid synthase and acetyl-CoA carboxylase were decreased. These findings demonstrate that chlorogenic acid effectively improves hepatic lipid dysregulation in rats by regulating fatty acid metabolism enzymes, stimulating AMP-activated protein kinase activation, and modulating levels of hepatic fatty acids.

Screening anaphylactoid components of Shuang Huang Lian Injection by analyzing spectrum–effect relationships coupled with UPLC–TOF–MS

“…Chlorogenic acid is recognized to be the main active component in honeysuckle (Li, Wang, & Luo, ; Zhou, Ruan, & Wen, ). Freedmanapos;s group first reported that chlorogenic acid might be the major allergen in green coffee.…”

Effects of Dietary Apple Polyphenols Supplementation on Hepatic Fat Deposition and Antioxidant Capacity in Finishing Pigs

“…The work of Ntambi et al has confirmed that the decrease of Δ9 dehydrogenase activity could improve insulin sensitivity in mice [39]. The work of Zhou et al has reported that the decrease of Δ9 dehydrogenase activity in the liver helped to inhibit hepatic fat deposition [40]. Moreover, there is a close relationship between fatty acid composition and metabolic syndromes in individuals, such as insulin resistance and diabetes [41].…”

Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation

“…Some studies have shown that CGA is the anti‐inflammatory compound in CGA‐containing natural products . Importantly, CGA has been reported to be biologically active to protect against experimental liver injuries . A recent study of CGA reported its protective effect against liver injury caused by bile duct ligation, involving transcriptional regulation of collagen and growth factor expression .…”

“…[10,21] Importantly, CGA has been reported to be biologically active to protect against experimental liver injuries. [24][25][26] A recent study of CGA reported its protective effect against liver injury caused by bile duct ligation, involving transcriptional regulation of collagen and growth factor expression. [27] However, no effect of CGA action on bile acid metabolism and cholestatic inflammation was found in previously reported intrahepatic cholestasis models.…”