Effects of Dietary Apple Polyphenols Supplementation on Hepatic Fat Deposition and Antioxidant Capacity in Finishing Pigs

Xu, Xiang; Chen, Xiaoling; Huang, Zhiqing; Chen, Shuai; He, Jun; Zheng, Ping; Chen, Hong; Luo, Junqiu; Luo, Yuheng; Yu, Bing; Yu, Jie

doi:10.3390/ani9110937

Cited by 13 publications

(14 citation statements)

References 49 publications

(55 reference statements)

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“…Hepatocellular steatosis is a characteristic of NAFLD. More than 5% of hepatocyte steatosis is necessary for the diagnosis of NAFLD [25,26]. In addition, it has been reported that exacerbations of steatosis are positively correlated with lobular inflammation, zone-3 fibrosis, and definite steatohepatitis [25].…”

Section: Discussionmentioning

confidence: 99%

Hepatic Inflammatory Response to Exogenous LPS Challenge is Exacerbated in Broilers with Fatty Liver Disease

Mei

Hao

Xie

et al. 2020

Animals

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This study aimed to examine hepatic function and inflammatory response in broilers with fatty livers, following acute lipopolysaccharide (LPS) challenge. One-day-old Lihua yellow broilers were fed a basal diet. Broilers were divided into four groups: control (CON), corticosterone treatment (CORT), LPS treatment (LPS), and LPS and CORT treatment (LPS&CORT). Results show that CORT induced an increase in plasma and liver triglycerides (TGs), which were accompanied by severe hepatic steatosis. The LPS group showed hepatocyte necrosis with inflammatory cell infiltration. Total liver damage score in the LPS&CORT group was significantly higher than that in the LPS group (p < 0.05). Activity levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were similar in the CON and CORT groups, but higher in the LPS group. Gene expression upregulation of the proinflammatory cytokines (NF-κB, IL-1β, IL-6, IFN-γ, and iNOS) was also noted in the LPS group (p < 0.05). In particular, LPS injection exacerbated the gene expression of these proinflammatory cytokines, even when accompanied by CORT injections (p < 0.05). In summary, our results indicate that broilers suffering from fatty liver disease are more susceptible to the negative effects of LPS, showing inflammatory response activation and more severe damages to the liver.

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Section: Discussionmentioning

confidence: 99%

Hepatic Inflammatory Response to Exogenous LPS Challenge is Exacerbated in Broilers with Fatty Liver Disease

Mei

Hao

Xie

et al. 2020

Animals

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“…The clinical observation that increased intake of apples (rich in quercetin) protects against abdominal aortic calcification in older women 160 aligns with experimental data. Indeed, apple polyphenols, the major antioxidants in apples, have been shown to possess wide-ranging beneficial biological functions that could benefit patients with CKD 161 . In dipterans, acute treatment with quercetin has already been demonstrated to be geroprotective 162 and in a rat model of CKD quercetin protects kidney function 163 .…”

Section: Nutrients That Target Senescencementioning

confidence: 99%

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

et al. 2020

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stress and premature ageing are common features of the uremic phenotype.• The foodome -defined as the pool of all compounds present in a food sample and/or in a biological system interacting with the investigated food -can be implicated in the modulation of CKD complications.• Imbalance in the relative diversity of the gut microbiota has been studied extensively in CKD due its links with inflammation and cardiovascular risk. In this direction, researchers are evaluating the effects of pre-, pro-and synbiotics and many others food components like polyphenol-rich foods, sugar, proteins, etc. on both the modulation of the diversity of the gut microbiota and reduction in the levels of uremic toxins .• The use of bioactive compounds, found in curcumin, broccoli sprouts, berries, propolis, etc. may be valid nutritional therapeutic agents to modulate the expression of pro-inflammatory transcription factors, such as Nrf2, NF-kB and the inflammasome.• Senotherapeutic dietary compounds may mitigate the effects of a dysregulated ageing process in CKD and associated complications. including disturbed mitochondrial metabolism.Onion and garlic -may decrease NLRP3 activation Spinach -rich in betaine Green leafy vegetables -rich in folate Cruciferous vegetables, -rich in sulforaphane -may decrease NLRP3 activation, Nrf2 activators Some vegetables, such as spinach, broccoli, potatoes, cucumbers, green leafy -rich in potassium.

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“…For instance, apple polyphenols have the potential to be hepatoprotective and inhibit hepatic steatosis [ 25 ]. As a feed additive for pigs, apple polyphenols can reduce fat deposits in the liver of finishing pigs, improve lipid distribution, and strengthen the distribution of antioxidant enzymes [ 26 ]. Moreover, apple polyphenols are potentially effective dietary supplements and protect the stomach lining from damage by aspirin [ 27 ], protect colonic mucosa in ulcerative colitis [ 28 ], and reduce inflammatory processes, which lead to bowel disease [ 29 ].…”

Section: Polyphenolsmentioning

confidence: 99%

Malus domestica: A Review on Nutritional Features, Chemical Composition, Traditional and Medicinal Value

Patočka

Bhardwaj

Klímová

et al. 2020

Plants

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Fruit-derived bioactive substances have been spotlighted as a regulator against various diseases due to their fewer side effects compared to chemical drugs. Among the most frequently consumed fruits, apple is a rich source of nutritional molecules and contains high levels of bioactive compounds. The main structural classes of apple constituents include polyphenols, polysaccharides (pectin), phytosterols, and pentacyclic triterpenes. Also, vitamins and trace elements complete the nutritional features of apple fruit. There is now considerable scientific evidence that these bioactive substances present in apple and peel have the potential to improve human health, for example contributing to preventing cardiovascular disease, diabetes, inflammation, and cancer. This review will focus on the current knowledge of bioactive substances in apple and their medicinal value for human health.

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Effects of Dietary Apple Polyphenols Supplementation on Hepatic Fat Deposition and Antioxidant Capacity in Finishing Pigs

Cited by 13 publications

References 49 publications

Hepatic Inflammatory Response to Exogenous LPS Challenge is Exacerbated in Broilers with Fatty Liver Disease

Hepatic Inflammatory Response to Exogenous LPS Challenge is Exacerbated in Broilers with Fatty Liver Disease

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

Malus domestica: A Review on Nutritional Features, Chemical Composition, Traditional and Medicinal Value

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