Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation

Tan, Zhenghuai; Luo, Moulun; Yang, Jinjin; Cheng, Yuqing; Huang, Jing; Lu, Caide; Song, Danjun; Ye, Meiling; Dai, Manyun; Gonzalez, Frank J.; Liu, Aiming; Guo, Bin

doi:10.1111/jphp.12592

Cited by 37 publications

(16 citation statements)

References 48 publications

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“…IL-10 inhibits the binding of NF-κB with DNA activity from the cytoplasm to the nucleus by inhibiting the activity of nuclear factor (IKK), inhibits the NF-κB activity, and reduces the release of TNFα, thereby reducing the inflammatory response (7). Thus, the data suggest that quercetin significantly suppressed NF-κB in ALD mice.…”

Section: Discussionmentioning

confidence: 54%

“…In addition, the metabolism of alcohol in the liver results in a large number of free radicals, which inhibits fatty acid oxidation, accumulates intrahepatic fat when beyond the body's clearing ability, and also leads to lipid peroxidation of liver cell membrane, resulting in liver cell damage (12). At the same time, these reactive oxygen species will increase the level of endotoxin, and lead to the release of inflammatory mediators, which can also make NF-κB activated, thus generating a large number of inflammatory mediators, to have an inflammatory cascade amplification effect, aggravating liver damage (7). Quercetin ( Fig.…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, the selective knockdown of STAT3 in murine hepatocyte may aggravate the degree of ALD, whereas the selective knockdown of STAT3 from endothelial cells in mice can significantly reduce endothelial and hepatic damage (6). The studies in the effects of STAT3 on different cells show that STAT3 plays a role of proinflammatory cytokine in hepatocytes, which may be related to the release of various cytokines and regulatory proteins in stimulated hepatocytes; STAT3 in macrophages and neutrophils from bone marrow has the anti-inflammatory effect, and plays a leading role in ALD (5,7).…”

Section: Introductionmentioning

confidence: 99%

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Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

2017

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Abstract. Quercetin is a type of flavonoid compound, which has potent antioxidant and anti-inflammatory activities, capable of treating a variety of diseases including neurodegenerative diseases, tumors, diabetes and obesity. The present study selected alcohol-induced liver injury model mice and aimed at studying the protective role of quercetin in preventing alcohol-induced liver injury. In alcohol-induced liver injury mice treated with quercetin, it was demonstrated that levels of aspartate transaminase, alanine transaminase, total bilirubin and triglyceride were reduced. In addition to this, the activities of the antioxidant enzymes superoxide dismutase and glutathione peroxidase were increased, malondialdehyde was inhibited, and interleukin (IL)-1β, IL-6, IL-10 and inducible nitric oxide synthase were suppressed. Quercetin additionally suppressed the protein expression levels of B-cell lymphoma (Bcl)-2, Bcl-2 associated X apoptosis regulator, Caspase-3, poly ADP-ribose polymerase, and signal transducer and activator of transcription (STAT) 3 phosphorylation, nuclear factor (NF)-κB and protein kinase B (Akt) phosphorylation levels in alcohol-induced liver injured mice. These results suggested that the protective role of quercetin prevents alcohol-induced liver injury through the phosphoinositide 3-kinase/Akt/NF-κB and STAT3 pathway.

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

2017

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“…The exact mechanisms of STAT3 inhibition by ACE and active ingredients inhibiting STAT3 activity remain elusive. Several compounds in ACE including capillarisin, scoparone, scopoletin and cholorogenic acid have been reported to suppress the activity of STAT3 (24,(29)(30)(31). Thus, it can be postulated that several compounds in ACE are responsible for STAT3 inhibition.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antitumor activity of Artemisia capillaris extract against hepatocellular carcinoma through the inhibition of IL-6/STAT3 signaling axis

et al. 2016

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Interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway plays critical roles in the development and progression of hepatocellular carcinoma (HCC). Artemisia capillaris (AC) has been widely used to treat various liver diseases including HCC as a herbal medicine. The effects of AC on IL-6/STAT3 signaling axis in HCC cells and subsequent anticancer activity of AC against HCC were analyzed using HCC cell lines and HBV W4P-LHB-expressing NIH3T3 cell line, which has been shown to gain tumorigenicity by activating IL-6/STAT3 signaling in our previous study. AC extract significantly suppressed the growth and colony formation of HCC cells. In addition, it inhibited the activation of STAT3 by IL-6 and subsequent synthesis of downstream molecules in HCC and W4P-NIH3T3 cells. Consequently, migration of cells was significantly suppressed by the AC extract. Collectively, the findings suggest that AC extract is capable of conferring various antitumor effects against HCC through the modulation of the IL-6/STAT3 pathway. The results provide a basis for the therapeutic use of AC in the treatment of HCC. Identification of the compound responsible for the effect may lead to the development of a novel anticancer agent against HCC.

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“…Drugs Celastrol (27) Andrographolide (28) Rosuvastatin (29) Shenqi Fuzheng Injection (30) Peroxiredoxin 4 (31) 9-cis-retinoic acid (32) Schisandrol B (33) Glechoma hederacea (34) Chicken bile powder (35) Auraptene (36) SRT1720 (37) Sweroside (38) Chlorogenic acid (39) Vitamin C (40) Thymoquinone (41) Cilostazol (42) Quercetin (43) Guava Pulp (44) Serotonin (45) Docosahexaenoic acid (46) Cyclopamine (47) Resveratrol (48) Caffeic acid phenethyl ester (49) Tetrathiomolybdate (50) Aminoguanidine ( IL-1alpha, TNF-alpha a novel membrane-bound bile acid receptor expressed in many types of cells, which plays an important role in regulating energy homeostasis and glucose metabolism. In vitro experiments showed that TGR5 significantly inhibited macrophage function (66).…”

Section: Drug Therapy For Cholestatic Liver Injurymentioning

confidence: 99%

Anti-inflammatory, anti-oxidative stress and novel therapeutic targets for cholestatic liver injury

Zhang

et al. 2019

BST

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Cholestasis is a pathological process in which bile drainage is poor for a variety of reasons. Many studies have shown that cholestatic liver injury is a neutrophil-mediated inflammatory response, and oxidative stress induced by neutrophils is the main mechanism of liver cell death. The literature summarizes the bile acid signaling pathway, the neutrophil chemotaxis recruitment process during cholestasis, and the oxidative stress damage produced by neutrophil activation, summarizes the latest research progress. Sphingosine-1-phosphate receptor (S1PR) is a potential therapeutic target for cholestasis that reduces neutrophil aggregation without inhibiting systemic immune status. Early growth response factor 1 (Egr-1) may play a central role in the inflammation induced by cholestasis, and it is also a potential therapeutic target to inhibit the inflammation induced by cholestasis. Strengthening the antioxidant system of hepatocytes to cope with oxidative stress of neutrophils is a feasible treatment for cholestatic liver injury.

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Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation

Abstract: These data suggest that CGA inhibits both ANIT-induced intrahepatic cholestasis and the liver injury. This protective effect involves down-regulation of STAT3 and NFκB signalling.

Cited by 37 publications

References 48 publications

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

Evaluation of antitumor activity of Artemisia capillaris extract against hepatocellular carcinoma through the inhibition of IL-6/STAT3 signaling axis

Anti-inflammatory, anti-oxidative stress and novel therapeutic targets for cholestatic liver injury

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