Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

Zhu, Minghua; Zhou, Xuefeng; Zhao, Jinping

doi:10.3892/etm.2017.5329

Cited by 41 publications

(42 citation statements)

References 29 publications

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“…In the current study, our study showed that quercetin significantly reduced the levels of inflammatory factors in the liver of db / db mice. Previous researches also found that the improved inflammatory microenvironment induced by quercetin may be involved in multiple signaling pathways, such as inhibiting the TLR/NF‐κB signaling pathway and PI3K/Akt/NF‐κB/STAT3 pathway (Z. Wang et al, ; Zhu, Zhou, & Zhao, ). Our study confirmed that quercetin relieved liver inflammation of T2DM‐induced NAFLD, and its potential mechanisms is our next project.…”

Section: Discussionmentioning

confidence: 99%

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice

Yang

Cai

et al. 2019

Phytotherapy Research

145

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Multiphase pathological processes involve in Type 2 diabetes (T2DM)‐induced nonalcoholic fatty liver disease (NAFLD). However, the therapies are quite limited. In the present study, the hepatoprotective effects and underlying mechanisms of quercetin in T2DM‐induced NAFLD were investigated. T2DM‐induced NAFLD and quercetin treatment models were established in vivo and in vitro. The results revealed that quercetin alleviated serum transaminase levels and markedly reduced T2DM‐induced histological alterations of livers. Additionally, quercetin restored superoxide dismutase, catalase, and glutathione content in livers. Not only that, quercetin markedly attenuated T2DM‐induced production of interleukin 1 beta, interleukin 6, and TNF‐α. Accompanied by the restoration of the increased serum total bile acid (p = .0001) and the decreased liver total bile acid (p = .0005), quercetin could reduce lipid accumulation in the liver of db/db mice. Further mechanism studies showed that farnesoid X receptor 1/Takeda G‐protein‐coupled receptor 5 signaling pathways was involved in quercetin regulation of lipid metabolism in T2DM‐induced NAFLD. In high D‐glucose and free fatty acid cocultured HepG2 cells model, quercetin eliminated lipid droplets and restored the upregulated total cholesterol and triglyceride levels. Similar to the findings in mice, quercetin could also activate farnesoid X receptor 1/Takeda G‐protein‐coupled receptor 5 signaling pathway. These findings suggested that quercetin might be a potentially effective drug for the treatment of T2DM‐induced NAFLD.

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Section: Discussionmentioning

confidence: 99%

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice

Yang

Cai

et al. 2019

Phytotherapy Research

145

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“…22 Previous reports found that the improved inflammatory microenvironment induced by quercetin may be involved in multiple signaling pathways, such as inhibiting the TLR/NF-kB signaling pathway and the PI3K/Akt/NF-kB/STAT3 pathway. 13,23,24 In this study, reduction of plasma TG, TC and NEFA concentrations in the obesity disease cats was observed after quercetin derivative supplementation for 4 weeks. Longerterm supplementation with quercetin may be more effective on treatment for obesity disease.…”

Section: Discussionmentioning

confidence: 63%

<p>Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats</p>

Kobayashi¹,

Okada²,

Ueno³

et al. 2020

VMRR

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Background: Obesity has become a serious public health problem all over the world, and prevalence of obesity has increased in cats. Obesity is characterized by continuous low-grade inflammation based on oxidative stress by excessively produced reactive oxygen species (ROS). Supplementation with anti-oxidant and anti-inflammatory compounds is very effective to relieve the obesity condition. A plant extract mixture containing Rhus verniciflua and some other herbs, Rv-PEM01-99, shows anti-oxidant and anti-inflammatory effects in animals. The aim of this study was to evaluate the effects of supplementation with Rv-PEM01-99 as an anti-inflammatory compound in healthy and obese cats. Materials and Methods: Ten healthy mix breed cats and four obesity disease cats were used. The healthy cats were randomly divided into control and test groups. Antiinflammatory compound, Rv-PEM01-99, in which quercetin derivative is the main component, was supplemented to the healthy test group and the obesity disease cats at the dose of 100-120 mg/kg/day (2.5-3.0 mg/kg/day as quercetin) for 4 weeks. Metabolites, hormones and enzymes were measured before and after the compound supplementation. Results: The anti-inflammatory compound supplementation decreased serum amyloid A (SAA) concentrations as inflammatory markers in both healthy and obesity disease cats. In obesity disease cats, plasma total cholesterol concentrations and AST and ALT activities decreased significantly after the compound supplementation. Conclusion: Quercetin derivative seems to have strong anti-inflammatory activities. In the healthy cats, anti-inflammatory compound supplementation decreased plasma NEFA and SAA concentrations. In the obesity disease cats, the compound supplementation may have alleviated obesity disease by relieving inflammation and improvement of lipid metabolism in livers.

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“…Ansar et al showed that QCT protected the liver against DNA damage induced by acrylamide (29). The QCT inhibits apoptosis in alcohol-induced liver toxicity (30), prevents apoptosis in hepatocytes of diabetic rats (31), and suppresses the apoptosis in mesangial cells of kidney exposed to H 2 O 2 (32). Anti-apoptotic impacts of QCT against traumatic brain injury were also reported by Yang et al (33).…”

Section: Discussionmentioning

confidence: 83%

Quercetin Effects on Hepatotoxicity Induced by Titanium Dioxide Nanoparticles in Rats

Shirani

Khorsandi

Alidadi

2019

Jundishapur J Nat Pharm Prod

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Background: Most nanoparticles have adverse impacts on the liver, which is a vital body organ, by the induction of oxidative stress. Objectives: This study was designed to evaluate the hepatoprotective effects of quercetin (QCT) against the toxicity of nanoscale titanium dioxide (NTiO2) in Wistar rats. Methods: The present study was conducted on 32 adult female Wistar rats assigned into 4 groups of control, NTiO2 (50 mg/kg), NTiO2 + Quercetin (50 + 75 mg/kg), and Quercetin (75 mg/kg). The animals exposed to NTiO2 were administered by 50 mg/kg of NTiO2 for 21 days. The Quercetin + NTiO2 rats received Quercetin before exposing to NTiO2 for 7 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) of serum were considered indicators of the hepatotoxicity. The oxidative stress was assessed by measuring the activity of catalase (CAT) and superoxide dismutase (SOD) as well as the level of malondialdehyde (MDA) in the liver. TUNEL assay and histological changes were also assessed. Results: The NTiO2 significantly elevated the MDA level (P < 0.01), enhanced the serum biomarker levels, reduced the CAT (P < 0.01) and SOD (P < 0.01) activities. The NTiO2 also aggregated the red blood cells, and caused inflammatory cell infiltration, nuclear pyknosis and fat deposit in hepatocytes, as well as induced apoptosis in the liver tissue. Pretreatment with QCT quenched oxidative stress, attenuated the histological changes, elevated the CAT (P < 0.01) and SOD (P < 0.01) activities, normalized the serum biomarker levels and decreased apoptosis (P < 0.001). Conclusions: The QCT has an inhibitory impact on hepatotoxicity induced by nanoparticles in rats.

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Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

Cited by 41 publications

References 29 publications

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice

<p>Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats</p>

Quercetin Effects on Hepatotoxicity Induced by Titanium Dioxide Nanoparticles in Rats

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