Chlordiazepoxide (Librium) and Tests of Thyroid Function

Abstract

, Isolation of Rubella Virus-Thompson and Tobin MMICAIJSOURNAL laboratory evidence of maternal infection in which neither virus excretion nor persistence of antibody can be demonstrated in the infant though the congenital abnormalities are typical of congenital rubella.It must be concluded that clinical rubella in the first trimester confirmed by the laboratory means an infected fetus. It also appears that termination of a pregnancy for suspected rubella without laboratory support for the diagnosis is destroying many fetuses unnecessarily.

The Effect of Chlordiazepoxide and Amylobarbitone upon Thyroid Function Tests

“…These findings suggest that both chlordiazepoxide and amylobarbitone given in standard dosage have no significant effect upon thyroid function as measured by the 131 I thyroid uptake, serum PB 131 I, serum PB 127 I levels or the ankle jerk time. In respect of chlordiazepoxide they agree with the findings of Oberman et al (1963) and with the results recently published by Clark and Hall (1970). They do not exclude the possibility of an effect upon thyroid function with larger doses or more prolonged therapy, and this may be the basis for the differing clinical experience.…”

“…four times a day. Clark and Hall (1970) also demonstrated no effect on thyroid function tests in euthyroid or thyrotoxic patients after a month's course of chlordiazepoxide in a dose of 10mg. three times a day.…”

Diazepam and Tests of Thyroid Function

“…These were similar to those used for chlordiazepoxide (Clark and Hall, 1970). Twelve euthyroid patients (11 women and 1 man, aged 29 to 54 years) and six patients with thyrotoxicosis (all women, aged 28 to 49) were tested before and after four weeks of therapy with diazepam 5 mg three times a day.…”

Effect of diazepam (Valium) on dialysable thyroxine

“…Both diazepam (Valium) and chlordiazepoxide (Librium) have been shown to depress the uptake of iodine by the thyroid gland in thyrotoxicosis and thus obscure the diagnosis of hyperthyroidism (Harvey, 1967;Turner & Sneddon, 1967). Clarke & Hall (1970), using radioactive iodine uptake and clearance, protein-bound iodine and tri-iodothyronine resin uptake, have investigated fourteen euthyroid and six mildly thyrotoxic patients and could detect no significant difference in the results of these tests before and during treatment with chlordiazepoxide over a 4-week period. Mazzaferri & Skillman (1969) found significant day-to-day fluctuations in radio-active iodine uptake and protein-bound iodine tests in twentyfour healthy adults on diazepam.…”