Diazepam and Tests of Thyroid Function

Clark, F.; Hall, R.; Ormston, B. J.

doi:10.1136/bmj.1.5749.585

Cited by 11 publications

(3 citation statements)

References 5 publications

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“…Ad ministration of 10 mg diazepam i.v. or orally failed to affect prolactin or TSH secretion, in agreement with several studies examining the effects of oral diazepam on thyroid function and prolactin release [4][5][6][13][14][15].…”

Section: Discussionsupporting

confidence: 69%

Failure to Confirm Consistent Stimulation of Growth Hormone by Diazepam

Levin

Sharp

Carlson³

1984

Horm Res

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Diazepam has been reported to influence pituitary hormone secretion, with several studies claiming that diazepam provokes growth hormone release. Normal volunteers were therefore examined for anterior pituitary responsiveness to 10 mg diazepam i.v. and p.o. The drug had no significant effect on the secretion of prolactin or thyrotropin when compared to control saline injections in all subjects. Growth hormone response was variable; serum growth hormone increased significantly in only 4 of 10 patients after i.v. diazepam and in only 1 of 7 subjects tested with oral diazepam. Serum cortisol rose in only 1 subject, precluding a stress-related explanation for the increase in growth hormone. We conclude that diazepam inconsistently stimulates growth hormone secretion and should not be relied upon as a test of growth hormone reserve.

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Section: Discussionsupporting

confidence: 69%

Failure to Confirm Consistent Stimulation of Growth Hormone by Diazepam

Levin

Sharp

Carlson³

1984

Horm Res

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“…They do not exclude the possibility of an effect upon thyroid function with larger doses or more prolonged therapy, and this may be the basis for the differing clinical experience. Diazepam, another benzodiazepine compound, has also been reported not to interfere with tests of thyroid function (Mazzaferri and Skillman, 1969; Greenberg, Czernichow and Blizzard, 1970; Clark, Hall and Ormston, 1971).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Chlordiazepoxide and Amylobarbitone upon Thyroid Function Tests

Slater

1972

Int J Clinical Practice

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“…The effect of diazepam on TSH and prolactin remained controversial [3][4][5][6][7] until a recent report, which demonstrated no altera tion of TSH and prolactin levels after oral administration of diazepam [8]. While GH rise after diazepam is abolished by hypergly cemia in normals [8], endogenous hypergly cemia of diabetes failed to abolish the re sponse of GH to diazepam [9].…”

Section: Introductionmentioning

confidence: 99%

Failure of Diazepam to Affect Growth Hormone and Prolactin in Acromegalics

Ajlouni¹

1983

Horm Res

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To demonstrate the effect of diazepam on serum growth hormone and prolactin levels in acromegaly, 7 acromegalics were studied. Every patient received 10 mg diazepam orally at zero time, and blood samples were obtained at 30-min intervals. The same patients also underwent a standard L-dopa test. They were given 500 mg L-dopa orally at zero time, and blood samples were obtained at 30-min intervals. The administration of diazepam did not induce any significant changes in either growth hormone or prolactin levels. On the other hand, the administration of L-dopa resulted in a significant decrease in growth hormone level from 74.25 ± 22 ng/ml (mean ± SEM) at zero time to a level of 52.8 ± 21 and 58.77 ± 22.7 ng/ml at the 60- and 90-min intervals, respectively (p < 0.05), and a significant decrease in prolactin level from a baseline of 56.18 ± 17 to 25.5 ± 8.4 ng/ml (p < 0.001) at the 60-min interval.It is suggested that the response of growth hormone to diazepam in acromegalics is qualitatively different from nonacromegalic controls.

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Diazepam and Tests of Thyroid Function

Cited by 11 publications

References 5 publications

Failure to Confirm Consistent Stimulation of Growth Hormone by Diazepam

Failure to Confirm Consistent Stimulation of Growth Hormone by Diazepam

The Effect of Chlordiazepoxide and Amylobarbitone upon Thyroid Function Tests

Failure of Diazepam to Affect Growth Hormone and Prolactin in Acromegalics

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