Effect of diazepam (Valium) on dialysable thyroxine

Nine normal, healthy male subjects had significantly elevated thyroid-stimulating hormone (TSH) concentrations while receiving oral lithium carbonate for two weeks. The mean minimum lithium serum concentration was 0.765 mEq/L. The TSH concentrations after 15 days on lithium were significantly correlated to the TSH concentration at baseline. No correlation was found between mean minimum lithium steady-state concentration and TSH concentration after 15 days on lithium. Further research is necessary to determine if a high baseline TSH concentration or an early rise in TSH will predict those patients who will eventually develop hypothyroidism after long-term lithium therapy.

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Effect of diazepam (Valium) on dialysable thyroxine

Abstract: SummaryShort-term treatment with diazepam constantly reduced the level of protein-bound iodine, the percentage dialysable thyroxine and the 'free' thyroxine iodine in ten euthyroid individuals, but the serumlevels remained within the normal range.

Cited by 4 publications

References 13 publications

On the interaction between thyroid hormones and the tranquillisers librium® and valium®

On the interaction between thyroid hormones and the tranquillisers librium® and valium®

Pharmacological interference with in vitro tests of thyroid function

Elevations in Thyroid-Stimulating Hormone in Normal Subjects after Receiving Short-Term Lithium Carbonate

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