Chlamydia trachomatis urogenital infection in women with infertility

Wilkowska-Trojniel, M; Zdrodowska-Stefanow, B; Ostaszewska-Puchalska, Iwona; Zbucka, Monika; Wołczyński, S; Grygoruk, Cezary; Kuczyński, Waldemar; Zdrodowski, M

doi:10.2478/v10039-009-0007-6

Cited by 16 publications

(13 citation statements)

References 20 publications

(6 reference statements)

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“…The prevalence of chlamydial infection in infertile women in this study was 8%. Similar prevalence was found in studies carried out in Oman (5.5%) [43], Central Saudi Arabia (8%) [26], Poland (8.7%) [44], Nigeria (9.6%) [35] and Brazil (10% and 10.9%) [39] [45]. However, higher prevalence was found by others studies carried out in Saudi Arabia (15%) [28], UK (16%) [36], India (28.1%) [46] and Iran (32%) [34].…”

Section: Discussionsupporting

confidence: 67%

Screenning of <i>Chlamydia trachomatis</i> Infection among Women Attending Outpatient Clinic of Infertility

Lavorato¹,

Moço²,

Martín³

et al. 2015

OJOG

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Objective: The goal of this study was to determine the prevalence of C. trachomatis in women diagnosed with infertility attending the Outpatient Clinic of Infertility from Botucatu Medical School, UNESP, Brazil. Patients and Methods: This molecular study enrolled a total of 112 women. Among these patients, 62 presented primary infertility while 50 presented secondary infertility. The criteria for eligibility included women who were: reproductive-aged; no prior report of seroconversion for HIV; no antibiotic or vaginal cream used in the preceding 30 days; and abstinence from sexual intercourse for 72 hours before the visit. The women were submitted to a gynecological examination and cervical samples were collected with an endocervical cytobrush for molecular analysis of C. trachomatis. Results: The prevalence of chlamydial infection was 8% with similar prevalence between primary (8.1%) and secondary (8.0%) infertility. Conclusion: Considering the asymptomatic nature of chlamydial infection and its association with tubal factor infertility, there is a pressing need to incorporate the screening of C. trachomatis infection as part of the routine investigation for infertility. The early diagnostic by screening can minimize complications and reduce Public Health costs with Assisted Reproductive Technology.

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Section: Discussionsupporting

confidence: 67%

Screenning of <i>Chlamydia trachomatis</i> Infection among Women Attending Outpatient Clinic of Infertility

Lavorato¹,

Moço²,

Martín³

et al. 2015

OJOG

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“…In a recent study, there was also no significant difference found in C. trachomatis antibody positivity when 104 infertile women were compared with 80 fertile women [22]. In contrast, there are earlier published reports on the high predictive value of C. trachomatis antibody positivity on tubal damage [23,24]. Another study has shown that combined use of the CAT test and medical history taking has superior diagnostic accuracy over one of these approaches alone [25].…”

Section: Discussionmentioning

confidence: 80%

Comparison of four serological assays for the diagnosis of Chlamydia trachomatis in subfertile women

Muvunyi

Claeys

Sutter

et al. 2011

J Infect Dev Ctries

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Introduction: Chlamydia antibody testing (CAT) in serum has been introduced as a screening method in the infertility workup. We evaluated the test characteristics of two ELISA tests compared to micro-immunofluorescence tests (MIFs). MIFs are considered the gold standard in the C. trachomatis IgG antibodies detection. We also compared the accuracy of all CAT tests in predicting tubal subfertility, using laparoscopy as a reference. Methodology: Four commercial serological methods were used to analyse 101 serum samples for the presence of C. trachomatis IgG antibodies from patients at the Infertility Clinic of Ghent University Hospital. The diagnostic utility for prediction of tubal infertility of serological methods was evaluated based on patients' medical records. Results: A comparison of the serological assays showed little difference in the major performance characteristics: the sensitivities of all MIFs and ELISAs were 100% for all assays (except the ELISA Vircell, with a sensitivity of 90%), and the specificities ranged from 92% for MIF Ani Labsystems to 98% for the MIF Focus and ELISA Vircell. As compared to laparoscopy data, CAT positivity in subfertile women with tubal damage (n=40) did not significantly differ from that of subfertile women without tubal damage (n=61): Positive predictive values (PPV) of CAT ranged from 53% to 60% and negative predictive values (NPV) ranged from 62% to 64%. Conclusion: evaluated ELISAs are comparable to MIFs in the detection of C. trachomatis IgG antibodies and should be preferred for large serological studies, especially in resource poor settings.

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“…Twenty-five to 35% of patients presenting for infertility evaluation have tubal disease (1-4). Chlamydia trachomatis is the primary sexually transmitted infection responsible for tubal factor infertility (TFI) (5-7) with C. trachomatis antibodies in approximately 70% of patients (8).…”

Section: Introductionmentioning

confidence: 99%

Genome-wide identification of Chlamydia trachomatis antigens associated with tubal factor infertility

Rodgers

Budrys

Gong

et al. 2011

Fertility and Sterility

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Objective To identify C. trachomatis antigens that can be used to differentially diagnose tubal factor infertility in comparison to previously reported Heat Shock Protein 60 (HSP60). Design In Vitro Study Patients Infertile women with and without tubal pathology diagnosed laparoscopically. Setting Academic medical center. Main Outcome Measures Antibody responses to C. trachomatis in infertile women with or without tubal pathologies using a C. trachomatis genome-wide proteome array. Results Comparison of the antibody profiles revealed 30 C. trachomatis antigens that were preferentially recognized by tubal factor infertility women with a detection sensitivity and specificity of 80.6% and 56.5%, respectively, 10 of which showed 100% specificity. A combination of CT443 and CT381 antigens yielded the highest detection sensitivity (67.7%) while maintaining 100% specificity. Conclusion These findings have demonstrated that antibodies to CT443 and CT381, when used in combination, have higher sensitivity and specificity in predicting tubal factor infertility than other indicators for tubal factor infertility such as HSP60 antibodies (35.5%, 100%) or hysterosalpingogram (65%, 83%). Using a panel of C. trachomatis antigens to serologically diagnose tubal factor infertility can save the patients from undertaking expensive and invasive procedures for determining tubal pathology and choosing treatment plans.

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Chlamydia trachomatis urogenital infection in women with infertility

Cited by 16 publications

References 20 publications

Screenning of <i>Chlamydia trachomatis</i> Infection among Women Attending Outpatient Clinic of Infertility

Screenning of <i>Chlamydia trachomatis</i> Infection among Women Attending Outpatient Clinic of Infertility

Comparison of four serological assays for the diagnosis of Chlamydia trachomatis in subfertile women

Genome-wide identification of Chlamydia trachomatis antigens associated with tubal factor infertility

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Chlamydia trachomatis urogenital infection in women with infertility

Cited by 16 publications

References 20 publications

Screenning of &lt;i&gt;Chlamydia trachomatis&lt;/i&gt; Infection among Women Attending Outpatient Clinic of Infertility

Screenning of &lt;i&gt;Chlamydia trachomatis&lt;/i&gt; Infection among Women Attending Outpatient Clinic of Infertility

Comparison of four serological assays for the diagnosis of Chlamydia trachomatis in subfertile women

Genome-wide identification of Chlamydia trachomatis antigens associated with tubal factor infertility

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Screenning of <i>Chlamydia trachomatis</i> Infection among Women Attending Outpatient Clinic of Infertility

Screenning of <i>Chlamydia trachomatis</i> Infection among Women Attending Outpatient Clinic of Infertility