Chlamydia

Pa, Mårdh; Puolakkainen, Mirja

doi:10.1007/978-1-4613-0719-8

Cited by 35 publications

(20 citation statements)

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“…The gender difference found in the C. pneumoniae-specific humoral response has been reported previously [26,27,311, but no explanation for this phenomenon has been found so far. As regards C. trachomatis, the antibody profile in the general population by age and gender is entirely different [32].…”

Section: Discussionmentioning

confidence: 99%

“…pneumoniae may produce chronic, silent infection in the bronchi or alveoli analogous to subclinical C. trachomatis infection in the fallopian tube. A large body of data has confirmed the causative role of C. trachomatis infection in pelvic inflammatory disease and its sequelae, tuba1 obstruction and infertility, over a course of years [32]. Whether similar mechanisms exist in chronic C. pneumoniae lung infection is not yet known.…”

Section: Discussionmentioning

confidence: 99%

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Immune responses to Chlamydia pneumoniae in twins in relation to gender and smoking

Hertzen

Surcel

Kaprio

et al. 1998

Journal of Medical Microbiology

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This study investigated whether gender or smoking has an impact on immune responses to Chlumydiapneumoniue in generally healthy adults. A total of 129 twins (46 twin pairs and 37 single twins) from the Finnish %in Cohort who had previously reported the highest discordance for smoking with their co-twins participated. C. pneumoniue-specific serum IgA and IgG antibody levels were measured by the micro-immunofluorescence test (micro-IF) at admission and 3 months later if the IgA level in the first sample was elevated. Cell-mediated immune (CMI) responses to C. pneumoniae and control antigens from heparinised blood samples were assessed by the lymphoproliferation (LP) assay. When all the subjects were pooled and analysed by gender and smoking status, marked differences in the humoral immune response between the genders were observed, irrespective of smoking status. When twin pairs solely were analysed, significantly elevated IgA antibody levels suggestive of persistent infection were found among the currently or formerly smoking men compared to their non-smoking co-twins. The CMI response showed a reciprocal trend with respect to humoral immunity. In conclusion, specific antibody levels were found to be higher in men than in women irrespective of smoking status, although smoking may further enhance the humoral response and depress the CMI response in men.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Immune responses to Chlamydia pneumoniae in twins in relation to gender and smoking

Hertzen

Surcel

Kaprio

et al. 1998

Journal of Medical Microbiology

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“…The same standardised reference serum samples, antihuman IgG enzyme conjugates, and cut off levels were used as in previous studies 3 4 5 6 7. The specificity of the chlamydia antibodies for C trachomatis was confirmed by identifying ELISA positive cases who were microimmunofluorescence positive (>1:32) for the C trachomatis serovars B,E,D/C,J,H,I/G,F,K/(Washington Research Foundation, Seattle)8 and for the solely genital C trachomatis serovar G,F,K,9 respectively.…”

Section: Methodsmentioning

confidence: 99%

Serologically diagnosed infection with human papillomavirus type 16 and risk for subsequent development of cervical carcinoma: nested case-control study

Lehtinen¹,

Dillner

Knekt

et al. 1996

BMJ

136

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“…C. trachomatis is a frequent cause of both complicated and non‐complicated genital tract infections [3]. In the industrialized countries tubal occlusion is found in up to 14–40% of female partners in couples seeking medical advice because of fertility problems [4].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Chlamydia trachomatis, Chlamydia psittaci and Chlamydia pneumoniae antibodies in blood donors and attendees of STD clinics

Bergström

Domeika

Vaitkienė³

et al. 1996

Clinical Microbiology and Infection

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OBJECTIVE: To estimate the prevalence of Chlamydia trachomatis, C. psittaci and C. pneumoniae antibodies in sera from altogether 931 blood donors, patients with symptoms of urethritis, assumed salpingitis and sexually acquired reactive arthritis (SARA), and women with fertility problems. METHODS: IgG antibodies to C. trachomatis, C. psittaci and C. pneumoniae were determined by microimmunofluorescence (MIF) tests. All patients were also tested for genital C. trachomatis infection using direct immunofluorescence (DIF) tests. RESULTS: The DIF-positive cases had a significantly (p < 0.0001) higher prevalence of C. trachomatis antibodies than the DIF negatives, i.e. 88.5% versus 14% in men with urethritis, 94.3% versus 36.4% in women with salpingitis, 66.7% versus 16.7% in SARA patients and 90.6% versus 20.8% in women with fertility problems. Antibody reactivity to all three chlamydial species was found significantly (p < 0.0001) more often in the patient groups and in those with a DIF-confirmed genital C. trachomatis infection than in blood donors. CONCLUSIONS: Presence of serum antibodies to C. trachomatis is tightly associated with the presence of chlamydiae in the genital tract, which also influences the cross-reactivities occurring in the MIF tests between chlamydial species.

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Chlamydia

Cited by 35 publications

References 0 publications

Immune responses to Chlamydia pneumoniae in twins in relation to gender and smoking

Immune responses to Chlamydia pneumoniae in twins in relation to gender and smoking

Serologically diagnosed infection with human papillomavirus type 16 and risk for subsequent development of cervical carcinoma: nested case-control study

Prevalence of Chlamydia trachomatis, Chlamydia psittaci and Chlamydia pneumoniae antibodies in blood donors and attendees of STD clinics

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