Chitosan-PVP-nano silver oxide wound dressing: In vitro and in vivo evaluation

Archana, D.; Singh, Bhawna; Dutta, Joydeep; Dutta, Parikshit

doi:10.1016/j.ijbiomac.2014.10.055

Cited by 312 publications

(156 citation statements)

References 49 publications

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“…In addition, AgNPs/chitosan materials could promote wound healing. 3,17,[28][29][30] In comparison with long-chain high molecular weight chitosan, the short-chain LMWC is better in terms of water solubility and biocompatibility. Besides, it has been confirmed that LMWC enhances the physical and chemical stability of many drugs such as insulin 31 and siRNA, 32 and works as a suitable carrier for the delivery and controlled release of drugs.…”

Section: Discussionmentioning

confidence: 99%

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Low molecular weight chitosan-coated silver nanoparticles are effective for the treatment of MRSA-infected wounds

Peng¹,

Song²,

Yang³

et al. 2017

IJN

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Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] However, the toxicology of AgNPs remains largely unknown. 5,6 Moreover, AgNPs can be absorbed into the bloodstream via different routes of administration, leading to deposition of silver in many organs, including the liver and spleen, and potential organ damage after a certain amount of accumulation.…”

Section: Introductionmentioning

confidence: 99%

Low molecular weight chitosan-coated silver nanoparticles are effective for the treatment of MRSA-infected wounds

Peng¹,

Song²,

Yang³

et al. 2017

IJN

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“…Pant et al [110] stated "gNPs containing nylon-6 nanoibers prepared by one-step electrospinning process could be an efective antimicrobial wound dressing to kill both Gram-negative E. coli and Gram-positive S. aureus. "rchana et al [111] evaluated chitosan-blended polyvinyl pyrrolidone (PVP)-nano silver oxide (CPS) as an efective wound dressing in vitro and in vivo.…”

Section: Silver Dressings In Wound Healingmentioning

confidence: 99%

Antimicrobial Dressings for Improving Wound Healing

Sarheed¹,

Ahmed²,

Shouqair³

et al. 2016

Wound Healing - New Insights Into Ancient Challenges

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Wound healing occurs by a series of interrelated molecular events which work together to restore tissue integrity and cellular function. These physiological events occur smoothly in normal healthy individual and/or under normal conditions. However, in certain cases, these molecular events are retarded resulting in hard-to-heal or chronic wounds arising from several factors such as poor venous return, underlying physiological or metabolic conditions such as diabetes as well as external factors such as poor nutrition. In most cases, such wounds are infected and infection also presents as another complicating phenomenon which triggers inlammatory reactions, therefore delaying wound healing. There has therefore been recent interests and signiicant eforts in preventing and actively treating wound infections by directly targeting infection causative agents through direct application of antimicrobial agents either alone or loaded into dressings (medicated). These have the advantage of overcoming challenges such as poor circulation in diabetic and leg ulcers when administered systemically and also require lower amounts to be applied compared to that required via oral or iv administration. This chapter will review and evaluate various antimicrobial agents used to target infected wounds, the means of delivery, and current state of the art, including commercially available dressings. Data sources will include mainly peer-reviewed literature, clinical trials and reports, patents as well as government reports where available.

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“…21,22 In addition, the use of this polycationic biopolymer in an antimicrobial formulation is interesting due to its biodegradability and antimicrobial activity. 1,23 An innovative strategy for antimicrobial nanoparticle formulations is to incorporate them into medical products, 24 mainly for wound dressings impregnated with silver nanoparticles 25,26 to inhibit bacterial growth (BG). A good candidate for this application is Veloderm ® , which is a biological wound dressing with good healing properties.…”

Section: Introductionmentioning

confidence: 99%

Triclosan resistance reversion by encapsulation in chitosan-coated-nanocapsule containing α-bisabolol as core: development of wound dressing

Marchi¹,

Jornada²,

Silva³

et al. 2017

IJN

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The use of nanoparticles may be particularly advantageous in treating bacterial infections due to their multiple simultaneous mechanisms of action. Nanoencapsulation is particularly useful for lipophilic drugs. In this scenario, triclosan is considered a good candidate due to its lipophilicity, broad-spectrum activity, and safety. In the present study, we have developed and characterized an antimicrobial suspension of triclosan and α-bisabolol against pathogenic strains that are resistant ( Pseudomonas aeruginosa ) and susceptible ( Escherichia coli , Staphylococcus aureus , and Candida albicans ) to triclosan. We also aimed to determine the minimum inhibitory concentration, using serial microdilution adapted from a CLSI methodology (Clinical and Laboratory Standards Institute). Challenge test was used to confirm the antimicrobial effectiveness of the nanocapsule formulation, as well as after its incorporation into a commercial wound dressing (Veloderm ® ). The zeta potential of P. aeruginosa before and after contact with cationic nanocapsules and the ratio between the number of nanocapsules per colony forming unit (CFU) were determined to evaluate a possible interaction between nanocapsules and bacteria. The results showed that nanoencapsulation has improved the antimicrobial activity when tested with two different methodologies. The number of nanocapsules per CFU was high even in great dilutions and the zeta potential was reverted after being in contact with the cationic nanocapsules. The nanocapsules were able to improve the activity of triclosan, even when tested within 28 days and when dried in the wound dressing.

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Chitosan-PVP-nano silver oxide wound dressing: In vitro and in vivo evaluation

Cited by 312 publications

References 49 publications

Low molecular weight chitosan-coated silver nanoparticles are effective for the treatment of MRSA-infected wounds

Low molecular weight chitosan-coated silver nanoparticles are effective for the treatment of MRSA-infected wounds

Antimicrobial Dressings for Improving Wound Healing

Triclosan resistance reversion by encapsulation in chitosan-coated-nanocapsule containing α-bisabolol as core: development of wound dressing

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Chitosan-PVP-nano silver oxide wound dressing: In vitro and in vivo evaluation

Cited by 312 publications

References 49 publications

Low molecular weight chitosan-coated silver nanoparticles are effective for the treatment of MRSA-infected wounds

Low molecular weight chitosan-coated silver nanoparticles are effective for the treatment of MRSA-infected wounds

Antimicrobial Dressings for Improving Wound Healing

Triclosan resistance reversion by encapsulation in chitosan-coated-nanocapsule containing &alpha;-bisabolol as core: development of wound dressing

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Product

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Triclosan resistance reversion by encapsulation in chitosan-coated-nanocapsule containing α-bisabolol as core: development of wound dressing