Chitosan/hydroxyapatite (HA)/hydroxypropylmethyl cellulose (HPMC) spongy scaffolds-synthesis and evaluation as potential alveolar bone substitutes

Iqbal, Haffsah; Ali, Moazzam; Zeeshan, Rabia; Mutahir, Zeeshan; Iqbal, Farasat; Nawaz, Muhammad Azhar Hayat; Shahzadi, Lubna; Chaudhry, Aqif Anwar; Yar, Muhammad; Luan, Shifang; Khan, Ather Farooq; Rehman, Ihtesham Ur

doi:10.1016/j.colsurfb.2017.09.059

Cited by 63 publications

(38 citation statements)

References 46 publications

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“…Drug release from DOXY-SPTS@hard capsules increased with the increase of drug loading, which was conversely applied to MLX-SPTS@hard capsules. Similar phenomenon was found in previous researches (Kumar & Mishra, 2006;Khampieng et al, 2014;Iqbal et al, 2017).…”

Section: In Vitro Release Behavior and Mechanismsupporting

confidence: 92%

Smart phase transformation system based on lyotropic liquid crystalline@hard capsules for sustained release of hydrophilic and hydrophobic drugs

Zhang

Xiao²,

Huang

et al. 2020

Drug Delivery

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Smart phase transformation systems@hard capsule (SPTS@hard capsule) based on lyotropic liquid crystalline (LLC) were developed for oral sustained release in this study. Doxycycline hydrochloride (DOXY) and meloxicam (MLX) were used as hydrophilic and hydrophobic model drug, respectively. Two systems were added with different additives, that is, gelucire 39/01, PEG 1000 and Tween 80 to adjust their melting point and release profiles. The phase transformation of these systems could be triggered by water as well as temperature. They could spontaneously transform into cubic phase or hexagonal phase when coming across with water, to achieve the 24 h sustained release profile. In addition, the obtained systems could switch between semisolid state and liquid state when temperature changed within room temperature and body temperature, which facilitated the phase transformation in gastrointestinal tract and during their encapsulation into hard capsules. LLC-based SPTS@hard capsule revealed potential for the industrialization of its oral administration on account of its drugs accommodation with different solubility, controllable release profile and simple preparation process.

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Section: In Vitro Release Behavior and Mechanismsupporting

confidence: 92%

Smart phase transformation system based on lyotropic liquid crystalline@hard capsules for sustained release of hydrophilic and hydrophobic drugs

Zhang

Xiao²,

Huang

et al. 2020

Drug Delivery

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“…Ideally, degradation should be matched to be replaced by mature bony tissue, in order to ensure that the scaffold does not collapse in the regeneration time span (Levengood & Zhang, ; Rezwan, Chen, Blaker, & Boccaccini, ). Furthermore, during scaffold degradation, the osteoconductive HA ceramic particles directly contact with the newly formed bone, and should promote osteointegration (Iqbal et al, ). From Figure we could predict that the matrices will be completely degraded after 4.4, 5.3, or 6.1 months for 0, 1, or 5% nHA, respectively.…”

Section: Discussionmentioning

confidence: 99%

Nanobiocomposite based on natural polyelectrolytes for bone regeneration

Belluzo

Medina

Molinuevo

et al. 2020

J Biomedical Materials Res

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“…The biomaterials used for scaffold preparation are natural biopolymers, synthetic polymers, ceramics and composites [ 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ]. Natural biopolymers include chitosan [ 28 , 60 , 61 , 62 , 63 ], alginate [ 46 , 64 , 65 ], cellulose [ 66 , 67 , 68 ], collagen [ 33 , 35 , 69 ], hyaluronan [ 70 , 71 , 72 ], fibrin [ 73 , 74 , 75 , 76 ] and silk [ 77 , 78 ]. The most commonly used synthetic polymers for scaffold preparation include poly (L-lactic acid) (PLA) [ 79 , 80 ], poly(lactic-co-glycolic acid) (PLGA) [ 81 , 82 , 83 , 84 ], polycaprolactone (PCL) [ 80 , 85 , 86 ], and poly(propylene fumarate) (PPF) [ 87 , 88 ].…”

Section: Biomaterials For Scaffold Fabricationmentioning

confidence: 99%

Reconstruction of Craniomaxillofacial Bone Defects Using Tissue-Engineering Strategies with Injectable and Non-Injectable Scaffolds

Gaihre

Uswatta

Jayasuriya

2017

JFB

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Engineering craniofacial bone tissues is challenging due to their complex structures. Current standard autografts and allografts have many drawbacks for craniofacial bone tissue reconstruction; including donor site morbidity and the ability to reinstate the aesthetic characteristics of the host tissue. To overcome these problems; tissue engineering and regenerative medicine strategies have been developed as a potential way to reconstruct damaged bone tissue. Different types of new biomaterials; including natural polymers; synthetic polymers and bioceramics; have emerged to treat these damaged craniofacial bone tissues in the form of injectable and non-injectable scaffolds; which are examined in this review. Injectable scaffolds can be considered a better approach to craniofacial tissue engineering as they can be inserted with minimally invasive surgery; thus protecting the aesthetic characteristics. In this review; we also focus on recent research innovations with different types of stem-cell sources harvested from oral tissue and growth factors used to develop craniofacial bone tissue-engineering strategies.

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Chitosan/hydroxyapatite (HA)/hydroxypropylmethyl cellulose (HPMC) spongy scaffolds-synthesis and evaluation as potential alveolar bone substitutes

Cited by 63 publications

References 46 publications

Smart phase transformation system based on lyotropic liquid crystalline@hard capsules for sustained release of hydrophilic and hydrophobic drugs

Smart phase transformation system based on lyotropic liquid crystalline@hard capsules for sustained release of hydrophilic and hydrophobic drugs

Nanobiocomposite based on natural polyelectrolytes for bone regeneration

Reconstruction of Craniomaxillofacial Bone Defects Using Tissue-Engineering Strategies with Injectable and Non-Injectable Scaffolds

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